Jing Huang, Hongqi Huo, Mulan Chen, Lili Wang, Nani Li, Zhijian Huang, Lin Yang
{"title":"纳米颗粒白蛋白结合紫杉醇在实验性癌症中比紫杉醇更有效","authors":"Jing Huang, Hongqi Huo, Mulan Chen, Lili Wang, Nani Li, Zhijian Huang, Lin Yang","doi":"10.1166/sam.2022.4251","DOIUrl":null,"url":null,"abstract":"Nab-paclitaxel is a water-soluable formulation of paclitaxel. It is more effective and less toxic than paclitaxel in treating cancer. Here we compared nab-paclitaxel with paclitaxel for their antitumor efficacy and toxicity in vitro and in a murine endometrial cancer model. Nab-paclitaxel\n was more effective than paclitaxel in inhibiting cancer cell growth. Nab-paclitaxel also caused cell apoptosis and cell cycle G1 arrest more effectively than paclitaxel. Similar effect was observed in mice model of endometrial cancer. In summary this preliminary study shows nab-paclitaxel\n is a promising therapeutic agent for endometrial cancer and deserves further studies.","PeriodicalId":21671,"journal":{"name":"Science of Advanced Materials","volume":null,"pages":null},"PeriodicalIF":0.9000,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Nanoparticle Albumin-Bound Paclitaxel is More Effective Than Paclitaxel in Experimental Endometrial Cancer\",\"authors\":\"Jing Huang, Hongqi Huo, Mulan Chen, Lili Wang, Nani Li, Zhijian Huang, Lin Yang\",\"doi\":\"10.1166/sam.2022.4251\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Nab-paclitaxel is a water-soluable formulation of paclitaxel. It is more effective and less toxic than paclitaxel in treating cancer. Here we compared nab-paclitaxel with paclitaxel for their antitumor efficacy and toxicity in vitro and in a murine endometrial cancer model. Nab-paclitaxel\\n was more effective than paclitaxel in inhibiting cancer cell growth. Nab-paclitaxel also caused cell apoptosis and cell cycle G1 arrest more effectively than paclitaxel. Similar effect was observed in mice model of endometrial cancer. In summary this preliminary study shows nab-paclitaxel\\n is a promising therapeutic agent for endometrial cancer and deserves further studies.\",\"PeriodicalId\":21671,\"journal\":{\"name\":\"Science of Advanced Materials\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.9000,\"publicationDate\":\"2022-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Science of Advanced Materials\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://doi.org/10.1166/sam.2022.4251\",\"RegionNum\":4,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Science of Advanced Materials","FirstCategoryId":"88","ListUrlMain":"https://doi.org/10.1166/sam.2022.4251","RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Nanoparticle Albumin-Bound Paclitaxel is More Effective Than Paclitaxel in Experimental Endometrial Cancer
Nab-paclitaxel is a water-soluable formulation of paclitaxel. It is more effective and less toxic than paclitaxel in treating cancer. Here we compared nab-paclitaxel with paclitaxel for their antitumor efficacy and toxicity in vitro and in a murine endometrial cancer model. Nab-paclitaxel
was more effective than paclitaxel in inhibiting cancer cell growth. Nab-paclitaxel also caused cell apoptosis and cell cycle G1 arrest more effectively than paclitaxel. Similar effect was observed in mice model of endometrial cancer. In summary this preliminary study shows nab-paclitaxel
is a promising therapeutic agent for endometrial cancer and deserves further studies.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
