{"title":"ACE2 COVID-19在阿尔茨海默病中的靶点","authors":"Daniela A Gutiérrez","doi":"10.34297/ajbsr.2021.14.001951","DOIUrl":null,"url":null,"abstract":"The COVID-19 pandemic is caused by the severe acute respiratory syndrome coronavirus (SARS-CoV-2). SARS-CoV-2 spike proteins target the angiotensin-converting enzyme 2 (ACE2) receptors localized mainly in the lungs. Recent studies have shown that SARS-CoV-2 also targets the CNS neurons and glial cells, triggering a cytokine immune-inflammatory response, compromising the blood-brain barrier, and ultimately causing neuronal death [1,2]. Thus, neurological diseases like Alzheimer’s disease (AD) are a particular comorbidity for COVID-19.","PeriodicalId":93072,"journal":{"name":"American journal of biomedical science & research","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2021-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The ACE2 COVID-19 target in Alzheimer’s disease\",\"authors\":\"Daniela A Gutiérrez\",\"doi\":\"10.34297/ajbsr.2021.14.001951\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The COVID-19 pandemic is caused by the severe acute respiratory syndrome coronavirus (SARS-CoV-2). SARS-CoV-2 spike proteins target the angiotensin-converting enzyme 2 (ACE2) receptors localized mainly in the lungs. Recent studies have shown that SARS-CoV-2 also targets the CNS neurons and glial cells, triggering a cytokine immune-inflammatory response, compromising the blood-brain barrier, and ultimately causing neuronal death [1,2]. Thus, neurological diseases like Alzheimer’s disease (AD) are a particular comorbidity for COVID-19.\",\"PeriodicalId\":93072,\"journal\":{\"name\":\"American journal of biomedical science & research\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-08-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"American journal of biomedical science & research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.34297/ajbsr.2021.14.001951\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"American journal of biomedical science & research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.34297/ajbsr.2021.14.001951","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The COVID-19 pandemic is caused by the severe acute respiratory syndrome coronavirus (SARS-CoV-2). SARS-CoV-2 spike proteins target the angiotensin-converting enzyme 2 (ACE2) receptors localized mainly in the lungs. Recent studies have shown that SARS-CoV-2 also targets the CNS neurons and glial cells, triggering a cytokine immune-inflammatory response, compromising the blood-brain barrier, and ultimately causing neuronal death [1,2]. Thus, neurological diseases like Alzheimer’s disease (AD) are a particular comorbidity for COVID-19.
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