实验药敏试验中物质来源的比较

IF 2.3 Q3 PHARMACOLOGY & PHARMACY Scientia Pharmaceutica Pub Date : 2023-02-09 DOI:10.3390/scipharm91010010
Filip Bielec, M. Brauncajs, D. Pastuszak-Lewandoska
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引用次数: 2

摘要

在规划研究时,资金往往是一个制约因素,特别是在基础研究资金不足的国家。研究人员必须考虑到这些限制,例如,在适当试剂的选择方面,其来源可能会影响研究的最终结果。本文的目的是比较使用三种不同来源的抗菌药物的细菌敏感性测试结果:供应商提供的纯粉末和两种不同赋形剂的片剂配方。所选物质为呋喃吡啶(硝基呋喃衍生物)。采用微量稀释法和纸片扩散法对45株尿路致病性肠杆菌进行了药敏试验。所得结果表明,尽管价格相对较高,但该粉末似乎是科学目的的最佳物质,特别是用于定量测定。
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Comparison of Substance Sources in Experimental Antimicrobial Susceptibility Testing
Funding is often a constraint when planning research, especially in countries where basic research is underfunded. Researchers must take into account these limitations, e.g., in relation to the selection of appropriate reagents, the source of which may affect the study’s final results. The aim of this article was to compare the results of bacteria susceptibility testing using three different sources of antimicrobial: the pure powder available from the supplier and two tablet formulations with different excipients. The chosen substance was furazidin (nitrofuran derivative). The susceptibility was tested on a group of 45 uropathogenic Enterobacterales using both microdilution and disk diffusion methods. The obtained results indicated that despite the relatively higher price, the powder appeared to be the best substance for scientific purposes, especially for quantitative determinations.
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来源期刊
Scientia Pharmaceutica
Scientia Pharmaceutica Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science
CiteScore
4.60
自引率
4.00%
发文量
67
审稿时长
10 weeks
期刊最新文献
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