罕见的,危及生命的胰腺腺癌首次亮相:肺肿瘤血栓性微血管病

Pablo Jiménez-Labaig , Soledad Fernández Solé , Susana Gómez Varela , Jorge García Calvo , Sergio Carrera Revilla , Alberto Muñoz Llarena
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引用次数: 0

摘要

肺肿瘤血栓性微血管病(PTTM)是一种与粘液分泌腺癌相关的副肿瘤综合征,通常是胃。粘蛋白分泌释放凝血级联,激活内皮生长因子,引起血栓形成和内皮细胞增殖,继发性管腔狭窄。PTTM通常在很短的时间内致命,提出了一个重大的死前诊断挑战。我们报告一例59岁的女性转移性胰腺腺癌发展为PTTM,导致肺心病和致死性心源性休克。这是第4例继发于胰腺腺癌的PTTM报告。这一临床怀疑在尸检中得到证实,当时发现了第二个以前未被发现的肿瘤。本报告强调了在当前肿瘤学实践中进行尸检研究的必要性。
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A rare, life-threatening debut of pancreatic adenocarcinoma: Pulmonary tumor thrombotic microangiopathy

Pulmonary tumor thrombotic microangiopathy (PTTM) is a paraneoplastic syndrome associated with mucin secreting adenocarcinomas, usually gastric. Mucin secretion releases the coagulation cascade and activates endothelial growth factors, causing thrombosis and endothelial proliferation with secondary luminal stenosis. PTTM, which is usually fatal in a very short time, presents a significant ante-mortem diagnostic challenge. We report the case of a 59-year-old woman with metastatic pancreatic adenocarcinoma who developed PTTM, leading to cor pulmonale and lethal cardiogenic shock. This is the fourth case report of PTTM secondary to pancreatic adenocarcinoma. The clinical suspicion was confirmed in the autopsy when a second, previously undetected tumor was found. This report highlights the need for postmortem studies in current oncology practice.

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