{"title":"类风湿关节炎前期研究综述","authors":"J. So, Hoch So","doi":"10.1142/s2661341723300021","DOIUrl":null,"url":null,"abstract":"Pre-rheumatoid arthritis (pre-RA) is the preclinical period before the diagnosis of rheumatoid arthritis (RA). Patients may suffer from arthralgia without clinically detectable arthritis. This period is characterized by a complex interaction of genetic, environmental, and host microbiomic factors leading to immune dysregulation, the production of autoantibodies, and finally joint inflammation. Around 30% of patients with undifferentiated arthritis progress to RA. Early identification of patients at the pre-RA stage might provide an opportunity for timely intervention, which may alter the natural history of the disease. In this narrative review, we will summarize the clinical features of pre-RA and the risk factors associated with the development of RA. The management of patients with a high risk of developing RA will also be discussed.","PeriodicalId":15538,"journal":{"name":"Journal of Clinical Rheumatology and Immunology","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Pre-Rheumatoid Arthritis: A Review\",\"authors\":\"J. So, Hoch So\",\"doi\":\"10.1142/s2661341723300021\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Pre-rheumatoid arthritis (pre-RA) is the preclinical period before the diagnosis of rheumatoid arthritis (RA). Patients may suffer from arthralgia without clinically detectable arthritis. This period is characterized by a complex interaction of genetic, environmental, and host microbiomic factors leading to immune dysregulation, the production of autoantibodies, and finally joint inflammation. Around 30% of patients with undifferentiated arthritis progress to RA. Early identification of patients at the pre-RA stage might provide an opportunity for timely intervention, which may alter the natural history of the disease. In this narrative review, we will summarize the clinical features of pre-RA and the risk factors associated with the development of RA. The management of patients with a high risk of developing RA will also be discussed.\",\"PeriodicalId\":15538,\"journal\":{\"name\":\"Journal of Clinical Rheumatology and Immunology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-07-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Clinical Rheumatology and Immunology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1142/s2661341723300021\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Clinical Rheumatology and Immunology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1142/s2661341723300021","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Pre-rheumatoid arthritis (pre-RA) is the preclinical period before the diagnosis of rheumatoid arthritis (RA). Patients may suffer from arthralgia without clinically detectable arthritis. This period is characterized by a complex interaction of genetic, environmental, and host microbiomic factors leading to immune dysregulation, the production of autoantibodies, and finally joint inflammation. Around 30% of patients with undifferentiated arthritis progress to RA. Early identification of patients at the pre-RA stage might provide an opportunity for timely intervention, which may alter the natural history of the disease. In this narrative review, we will summarize the clinical features of pre-RA and the risk factors associated with the development of RA. The management of patients with a high risk of developing RA will also be discussed.