Recent advances in polymer-supported proline-derived catalysts for asymmetric reactions

The last two decades have witnessed tremendous growth in organocatalysis, especially using proline and related catalysts in a wide range of organic processes. Along with this, the heterogenization of organocatalysts over suitable support systems also emerged as an effective approach for addressing some of the major drawbacks associated with classical organocatalysts. Polymer-immobilized catalysts, in particular, are extremely stable under reaction conditions with excellent recyclability and reusability. Moreover, this approach offers green chemistry standards and is, thereby, supportive of large-scale industrial manufacturing processes. This article summarises the developments using polymer immobilized proline-derived systems as efficient organocatalysts for various asymmetric transformations in Aldol, Michael, Mannich, cyclization reactions, etc.