委内瑞拉与COVID-19相关的毛霉病:对一个病例的考虑和文献综述。

IF 0.1 4区 医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Investigacion clinica Pub Date : 2023-06-01 DOI:10.54817/ic.v64n2a07
Cristina Royero-León, Mayira Sojo-Milano, Ligia Pérez-Castro, Dionelys Barazarte-Sánchez, J. Golaszewski, Rubén Muñoz-Gelvez, Fernando Gómez-Daza
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引用次数: 0

摘要

摘要毛霉病是一种新兴的、严重的、机会性的、侵袭性的真菌病,分布在世界各地,发病率低,发病率和死亡率高,与免疫缺陷有关。在印度等国家和一些美洲国家,与covid -19相关的毛霉病(CAM)出现了显著增加。我们描述了一个CAM病例的表现和管理,并讨论了文献中报道的CAM和非CAM病例的临床和公共卫生意义。使用时间线,流行病学,临床,微生物学,组织病理学,影像学特征,并在这个CAM病例多学科干预提出。来自委内瑞拉北部中部的64岁男性患者,有糖尿病史,有家庭护理的COVID-19中度发作,门诊治疗,表现为左单侧鼻-鼻窦-眶毛霉病伴牙颌延伸。确诊19天后,患者首发症状和体征为鼻窦炎、腭部改变、上颌疼痛、牙齿松动。组织病理学,直接检查和培养支持的菌丝学诊断表明根霉感染。患者成功地接受了两性霉素B、内镜下手术和代谢控制。我们讨论了COVID-19及其管理对CAM发展的影响,以及在这种情况下获得医疗保健的重要性。糖尿病合并COVID-19患者的潜在并发症中应考虑毛霉病。因此,必须在COVID-19临床的各个阶段提供全面的护理和监测。
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Mucormicosis asociada a la COVID-19 en Venezuela: consideraciones en torno a un caso y revisión de la literatura.
Abstract. Mucormycosis is an emerging, severe, opportunistic, invasive mycosis with a worldwide distribution, low frequency, and high morbidity and mortality linked to immunodeficiency conditions. A significant increase in COVID-19-associated mucormycosis (CAM) has occurred in countries such as India and several countries of the Americas. We describe the presentation and management of a CAM case and discuss the clinical and public health sig-nificance of its characteristics concerning CAM and non-CAM cases reported in the literature. Using a timeline, epidemiological, clinical, microbiological, histopathological, imaging features, and multidisciplinary interventions in this CAM case are presented. A 64-year-old male patient from the north cen-ter of Venezuela, with a history of diabetes mellitus and a home-cared mod-erate COVID-19 episode treated on an outpatient basis, presented with left unilateral rhino-sinus-orbital mucormycosis with dentomaxillary extension. His first symptoms and signs were sinusitis, palatal changes, maxillary region pain, and loosening of teeth 19 days after the COVID-19 diagnosis. Mycologi-cal diagnosis supported by histopathology, direct examination, and culture indicated a Rhizopus spp. infection. The patient was successfully treated with amphotericin B, surgery with an endoscopic approach, and metabolic control. We discuss the influence of COVID-19 and its management regarding CAM development, as well as the importance of access to healthcare in this situa-tion. Mucormycosis should be considered among potential complications in diabetic patients with COVID-19. Therefore, comprehensive care and moni-toring must be provided in all phases of the COVID-19 clinical picture.
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来源期刊
Investigacion clinica
Investigacion clinica MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
0.20
自引率
50.00%
发文量
2
审稿时长
>12 weeks
期刊介绍: Estudios humanos, animales y de laboratorio relacionados con la investigación clínica y asuntos conexos.
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