Yang Jiamin , Wu Jihui , Shen Xiaoyu , Zhang Mei , Liu Zhenzhen , Qi Dandan , Zhou Jin , Cui Xiao , Zhang Lufen , Li Yuhang
{"title":"灸丹中穴(CV 17)和肝俞穴(BL 18)对大鼠乳腺增生的影响","authors":"Yang Jiamin , Wu Jihui , Shen Xiaoyu , Zhang Mei , Liu Zhenzhen , Qi Dandan , Zhou Jin , Cui Xiao , Zhang Lufen , Li Yuhang","doi":"10.1016/j.jtcm.2018.01.007","DOIUrl":null,"url":null,"abstract":"<div><h3>OBJECTIVE</h3><p>To evaluate the efficacy of moxibustion, through stimulating acupoints of Danzhong (CV 17) and Ganshu (BL 18) in rats with hyperplasia of mammary gland (HMG) which induced by estrogen and progestogen.</p></div><div><h3>METHODS</h3><p>Thirty female Sprague-Dawley rats were randomly divided into saline control group, HMG model group, and HMG moxibustion group with 10 in each group. Saline control was the group injected by saline. HMG model were created by injection of estrogen and progestogen. Moxibustion group was also injected of estrogen and progestogen with moxibustion at the same time. The Changes of nipple diameter and height were measured. The rats’ skin temperature was recorded by an infrared thermal camera at the nipples, mammary areas, Danzhong (CV 17) and Ganshu (BL 18). Pathological changes of mammary gland in rats were also observed under light microscope.</p></div><div><h3>RESULTS</h3><p>The diameter and height of the nipples in model group were prominently bigger and higher than that in control group (<em>P</em> < 0.01). The diameter and height in moxibustion group were prominently smaller and lower than that in model group (<em>P</em> < 0.01), and there was no significant difference between moxibustion group and control group. Compared with control group, skin temperature of the nipples, mammary area, and acupoints Danzhong (CV 17) and Ganshu (BL 18) decreased prominently in model group (<em>P</em> < 0.01-0.05). Compared with model group, skin temperature of that in moxibustion group increased prominently (<em>P</em> < 0.05).</p></div><div><h3>CONCLUSION</h3><p>Treatment with moxibustion can effectively decrease the HMG rats’ nipple diameter and height, and increase the skin temperature in HMG model rats at the nipples, mammary areas, Danzhong (CV 17) and Ganshu (BL 18). This study convinces the therapeutic effect of moxibustion on mammary gland hyperplasia.</p></div>","PeriodicalId":17513,"journal":{"name":"Journal of Traditional Chinese Medicine","volume":"38 1","pages":"Pages 76-82"},"PeriodicalIF":2.0000,"publicationDate":"2018-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jtcm.2018.01.007","citationCount":"4","resultStr":"{\"title\":\"Efficacy of moxibustion by stimulating acupoints of Danzhong (CV 17) and Ganshu (BL 18) on hyperplasia of mammary gland in rats\",\"authors\":\"Yang Jiamin , Wu Jihui , Shen Xiaoyu , Zhang Mei , Liu Zhenzhen , Qi Dandan , Zhou Jin , Cui Xiao , Zhang Lufen , Li Yuhang\",\"doi\":\"10.1016/j.jtcm.2018.01.007\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>OBJECTIVE</h3><p>To evaluate the efficacy of moxibustion, through stimulating acupoints of Danzhong (CV 17) and Ganshu (BL 18) in rats with hyperplasia of mammary gland (HMG) which induced by estrogen and progestogen.</p></div><div><h3>METHODS</h3><p>Thirty female Sprague-Dawley rats were randomly divided into saline control group, HMG model group, and HMG moxibustion group with 10 in each group. Saline control was the group injected by saline. HMG model were created by injection of estrogen and progestogen. Moxibustion group was also injected of estrogen and progestogen with moxibustion at the same time. The Changes of nipple diameter and height were measured. The rats’ skin temperature was recorded by an infrared thermal camera at the nipples, mammary areas, Danzhong (CV 17) and Ganshu (BL 18). Pathological changes of mammary gland in rats were also observed under light microscope.</p></div><div><h3>RESULTS</h3><p>The diameter and height of the nipples in model group were prominently bigger and higher than that in control group (<em>P</em> < 0.01). The diameter and height in moxibustion group were prominently smaller and lower than that in model group (<em>P</em> < 0.01), and there was no significant difference between moxibustion group and control group. Compared with control group, skin temperature of the nipples, mammary area, and acupoints Danzhong (CV 17) and Ganshu (BL 18) decreased prominently in model group (<em>P</em> < 0.01-0.05). Compared with model group, skin temperature of that in moxibustion group increased prominently (<em>P</em> < 0.05).</p></div><div><h3>CONCLUSION</h3><p>Treatment with moxibustion can effectively decrease the HMG rats’ nipple diameter and height, and increase the skin temperature in HMG model rats at the nipples, mammary areas, Danzhong (CV 17) and Ganshu (BL 18). This study convinces the therapeutic effect of moxibustion on mammary gland hyperplasia.</p></div>\",\"PeriodicalId\":17513,\"journal\":{\"name\":\"Journal of Traditional Chinese Medicine\",\"volume\":\"38 1\",\"pages\":\"Pages 76-82\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2018-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.jtcm.2018.01.007\",\"citationCount\":\"4\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Traditional Chinese Medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0254627218300694\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"INTEGRATIVE & COMPLEMENTARY MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Traditional Chinese Medicine","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0254627218300694","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"INTEGRATIVE & COMPLEMENTARY MEDICINE","Score":null,"Total":0}
Efficacy of moxibustion by stimulating acupoints of Danzhong (CV 17) and Ganshu (BL 18) on hyperplasia of mammary gland in rats
OBJECTIVE
To evaluate the efficacy of moxibustion, through stimulating acupoints of Danzhong (CV 17) and Ganshu (BL 18) in rats with hyperplasia of mammary gland (HMG) which induced by estrogen and progestogen.
METHODS
Thirty female Sprague-Dawley rats were randomly divided into saline control group, HMG model group, and HMG moxibustion group with 10 in each group. Saline control was the group injected by saline. HMG model were created by injection of estrogen and progestogen. Moxibustion group was also injected of estrogen and progestogen with moxibustion at the same time. The Changes of nipple diameter and height were measured. The rats’ skin temperature was recorded by an infrared thermal camera at the nipples, mammary areas, Danzhong (CV 17) and Ganshu (BL 18). Pathological changes of mammary gland in rats were also observed under light microscope.
RESULTS
The diameter and height of the nipples in model group were prominently bigger and higher than that in control group (P < 0.01). The diameter and height in moxibustion group were prominently smaller and lower than that in model group (P < 0.01), and there was no significant difference between moxibustion group and control group. Compared with control group, skin temperature of the nipples, mammary area, and acupoints Danzhong (CV 17) and Ganshu (BL 18) decreased prominently in model group (P < 0.01-0.05). Compared with model group, skin temperature of that in moxibustion group increased prominently (P < 0.05).
CONCLUSION
Treatment with moxibustion can effectively decrease the HMG rats’ nipple diameter and height, and increase the skin temperature in HMG model rats at the nipples, mammary areas, Danzhong (CV 17) and Ganshu (BL 18). This study convinces the therapeutic effect of moxibustion on mammary gland hyperplasia.
期刊介绍:
Journal of Traditional Chinese Medicine(JTCM) is devoted to clinical and theortical research on the use of acupuncture and Oriental medicine. The main columns include Clinical Observations, Basic Investigations, Reviews, Questions and Answers, an Expert''s Forum, and Discussions of Clinical Cases. Its key topics include acupuncture and electro-acupuncture, herbal medicine, homeopathy, masseotherapy, mind-body therapies, palliative care, and other CAM therapies.