Treatment of tibial traumatic osteomyelitis with negative pressure closure drainage combined with open bone grafting or bone migration and its effect on the levels of CRP, TNF-α and IL-6 in the serum

Objective: To observe the effect of negative pressure closure drainage combined with open bone grafting or bone migration inthe treatment of tibial traumatic osteomyelitis. Methods: Eighty-six (86) cases of tibial traumatic osteomyelitis admitted to Hospital of the Chinese people's Liberation Armyfrom September 2017 to September 2018 were randomly divided into control group and observation group, forty-three (43)cases each. Debridement, open bone grafting or bone migration was given to the control group.The observation group was treated with negative pressure closed drainage on the basis of the control group. In addition, the serumcomponents such as CRP, TNF-α, IL-6 of the control group and observation group were detected respectively after surgery. Results: Observation group granulation cover wound, fracture healing time was shorter than the control group, fracture healingrate was better than the control group, the difference has statistical significance (P<0.05). By comparing serum CRP, TNF-α,IL-6 levels before and after treatment in the two groups, it was found that the observation group was lower than the controlgroup (P<0.05, respectively). Serum CRP, TNF-α, IL-6 levels were significantly (P<0.05). Conclusion: The treatment of tibial traumatic osteomyelitis with negative pressure closure drainage combined with open bonegrafting or bone displacement has a good effect on fracture healing and is worth popularizing. Keywords: Bone removal; CRP; IL-6; Negative pressure closure drainage; Tibia; TNF-α; Traumatic osteomyelitis.