健康和功能性肉制品。AFUSAN集团的科学证据

Q Pharmacology, Toxicology and Pharmaceutics Anales De La Real Academia Nacional De Farmacia Pub Date : 2021-12-31 DOI:10.53519/analesranf.2022.88.05.25
F. Sánchez-Muniz, A. Macho-González, S. Bastida, A. Garcimartín, A. Bocanegra, A. Canales, Meritxel Nus, Miguel Vázquez-Velasco, L. González-Torres, Rocío Redondo Castillejo, Marina Hernández Martín, María Elvira Muñoz López-Oliva, J. A. Santos, Paloma Celada, M. González-Muñoz, Adriana R Schultz Moreira, J. Benedí
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引用次数: 0

摘要

目前,人们认为肉类和肉制品的消费是过度的,容易导致最普遍的疾病。因此,获得具有“更健康”成分的肉类产品,甚至含有使其具有功能的生物活性成分,在健康方面具有相关性。概述了功能性食品的概念、获取方法及目前在保健中的意义。功能性肉制品的设计可以改变传统肉制品的营养成分,确保更长的保质期和氧化稳定性,以及帮助消费者改善一种或多种身体功能和/或减少患退行性疾病的风险。来自AFUSAN小组和其他研究人员的关于功能性肉类的出版物涉及将坚果或藻类等天然食物纳入肉类基质,以及有科学证据证明其作用的不同成分。健康方面:葡甘露聚糖、螺旋藻、羟基酪醇、奇亚油、硅、富含ω-3多不饱和脂肪酸的甘油三酯、角豆果肉中的多酚。研究已在心血管疾病高危人群(如超重/肥胖、血脂异常、高血压、吸烟)和小鼠模型(Wistar或Zucker fa/fa大鼠)中进行,这些小鼠模型诱导了高胆固醇血症、脂肪肝、肥胖或2型糖尿病。虽然每种功能成分似乎都能引起特定的变化,但可以指出的是,在许多情况下,与传统食品相比,这些功能食品能够在小鼠模型中发挥多效作用,改善脂蛋白谱,减少氧化应激和炎症等。在人类中,应强调血脂、血栓形成和氧化应激的相关结果。使用角豆提取物作为重组肉的功能性成分,对处于疾病不同阶段的2型糖尿病模型具有多重作用,特别是在肝脏和结肠中,改善了最后一个器官的抗氧化状态、肠道屏障的完整性和微生物群的多样性。这些结果表明食用肉类和传统肉类制剂对功能性产品的好处,这确保了通过肉类基质供应一些营养物质,并消除了那些意味着健康风险的营养物质。最后,在多元、功能性和精确饮食的框架内提出了未来的行动路线。关键词:功能肉;肉类保质期;氧化修饰功能效应;人类的;实验模型;肥胖;非酒精性脂肪肝;2型糖尿病
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Healthy and functional meat products. Scientific evidence of the AFUSAN group
At present, it is considered that the consumption of meat and meat products is excessive and predisposes towards the most prevalent pathologies. Therefore, obtaining meat products with a “healthier” composition and even containing bioactive ingredients that make them functional, acquires relevance in health. General aspects about concept, obtaining methods and current significance in health of functional foods are given. The design of a functional meat product makes it possible to modify the nutritional composition of conventional meat products and ensure a longer shelf life and oxidative stability, as well as helping consumers to improve one or more bodily functions and/or to decrease the risk of suffering degenerative diseases. The publications on functional meat from the AFUSAN group and from other researchers related to the incorporation of whole foods such as nuts or algae into meat matrices, as well as different ingredients for which there is scientific evidence on their role. in health: glucomannans, spirulina, hydroxytyrosol, chia oil, silicon, designer triglycerides enriched in ω-3 polyunsaturated fatty acids, polyphenols from carob pulp. Studies have been conducted in humans with high cardiovascular risk (e.g. overweight/obesity, dyslipidemia, hypertension, tobacco use) and in murine models (Wistar or Zucker fa/fa rats) in which hypercholesterolemia, fatty liver, obesity, or Type 2 Diabetes Mellitus was induced. Although each functional ingredient seems to induce specific changes, it can be pointed out that in many cases these functional foods, compared to conventional ones, are capable of exerting pleiotropic effects in murine models, improving the lipoprotein profile, reducing, among other aspects, oxidative stress and inflammation. In humans, relevant results on lipemia, thrombogenesis and oxidative stress should be highlighted. The use of a carob extract as a functional ingredient of restructured meat exerts multiple effects in models of Type 2 Diabetes at different stages of the disease, particularly in liver and colon, improving in this last organ, the antioxidant status, the integrity of the intestinal barrier and the microbiota plurality. These results suggest the benefits of consuming meat and conventional meat preparations for functional products, which ensure the supply of some nutrients via the meat matrix and eliminate those that imply health risks. The work ends by proposing future lines of action within the framework of a plural, functional and precision diet. Keywords: functional meats; meat shelf life; oxidative modifications functional effects; human; experimental models; obesity; non-alcohlic fatty liver disease; type 2 Diabetes
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来源期刊
CiteScore
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期刊介绍: The Anales de la Real Academia Nacional de Farmacia� embraces all aspects of pharmaceutical sciences and is a quarterly journal that publishes basic and applied research on pharmaceutical sciences and related areas. It is a medium for reporting selected original and significant contributions to new pharmaceutical knowledge.
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