控制低血压的耳鼻喉手术患者S100B水平与术后认知功能障碍(POCD)事件的相关性

IF 0.9 Q3 MEDICINE, GENERAL & INTERNAL Bali Medical Journal Pub Date : 2022-12-01 DOI:10.15562/bmj.v11i3.3847
Boby Abdul Rahman, P. Airlangga, Andy Nauman Saputra, Prihatma Kriswidyatomo, Agustina Salinding, Hamzah, Maulidya, Muhtarum Yusuf
{"title":"控制低血压的耳鼻喉手术患者S100B水平与术后认知功能障碍(POCD)事件的相关性","authors":"Boby Abdul Rahman, P. Airlangga, Andy Nauman Saputra, Prihatma Kriswidyatomo, Agustina Salinding, Hamzah, Maulidya, Muhtarum Yusuf","doi":"10.15562/bmj.v11i3.3847","DOIUrl":null,"url":null,"abstract":"Introduction: Controlled hypotension is one of the techniques applied to several microscopic ear, nose, and throat (ENT) surgeries. However, this technique has risks and complications, which result in impaired perfusion and oxygenation of organs including the brain that could trigger the postoperative cognitive dysfunction (POCD). Damage that occurs in brain cells can trigger the secretion of biomarker proteins in the blood, one of which is S100B which can indicate nerve damage in the intra and postoperative period. This study aimed to analyze the correlation between S100B protein level and the incidence of POCD in patients who received ENT surgeries with controlled hypotension.\nMethods: A cross-sectional study was conducted among patients that underwent elective ENT surgeries at Dr. Soetomo General Academic Hospital, Surabaya, from July to August 2022. Cognitive function was assessed using Mini-mental State Examination (MMSE) at 12 hours before and 2 and 24 hours after surgery. The level of S100B was measured using enzyme-linked immunosorbent assay (ELISA) 12 hours prior surgery and 30 minutes post-surgery.\nResults: A total of 31 patients were recruited in the study, including a mean age of 31.7 years. The mean S100B levels in POCD patients pre- and postoperative were 311.97 ng/L, and 415.34 ng/L, respectively. In non-POCD patients, the mean levels of S100B pre and postoperative were 436.90 ng/L, and 444.29 ng/L, respectively. There were 3 (9.7%) patients experienced POCD. Our data suggested there was a significant difference between preoperative and postoperative S100B levels in the groups of patients with POCD (103.37ng/L) and non-POCD (7.38 ng/L) (p<0.001). Patients that experienced POCD had significantly increased S100B compared to those who did not.\nConclusion: There is a correlation between changes of S100B levels and the incidence of POCD in patients undergoing ENT surgeries with controlled hypotension.","PeriodicalId":44369,"journal":{"name":"Bali Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.9000,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Correlation of S100B level and postoperative cognitive dysfunction (POCD) events among patients with ear, nose and throat (ENT) surgeries with controlled hypotension\",\"authors\":\"Boby Abdul Rahman, P. Airlangga, Andy Nauman Saputra, Prihatma Kriswidyatomo, Agustina Salinding, Hamzah, Maulidya, Muhtarum Yusuf\",\"doi\":\"10.15562/bmj.v11i3.3847\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Introduction: Controlled hypotension is one of the techniques applied to several microscopic ear, nose, and throat (ENT) surgeries. However, this technique has risks and complications, which result in impaired perfusion and oxygenation of organs including the brain that could trigger the postoperative cognitive dysfunction (POCD). Damage that occurs in brain cells can trigger the secretion of biomarker proteins in the blood, one of which is S100B which can indicate nerve damage in the intra and postoperative period. This study aimed to analyze the correlation between S100B protein level and the incidence of POCD in patients who received ENT surgeries with controlled hypotension.\\nMethods: A cross-sectional study was conducted among patients that underwent elective ENT surgeries at Dr. Soetomo General Academic Hospital, Surabaya, from July to August 2022. Cognitive function was assessed using Mini-mental State Examination (MMSE) at 12 hours before and 2 and 24 hours after surgery. The level of S100B was measured using enzyme-linked immunosorbent assay (ELISA) 12 hours prior surgery and 30 minutes post-surgery.\\nResults: A total of 31 patients were recruited in the study, including a mean age of 31.7 years. The mean S100B levels in POCD patients pre- and postoperative were 311.97 ng/L, and 415.34 ng/L, respectively. In non-POCD patients, the mean levels of S100B pre and postoperative were 436.90 ng/L, and 444.29 ng/L, respectively. There were 3 (9.7%) patients experienced POCD. Our data suggested there was a significant difference between preoperative and postoperative S100B levels in the groups of patients with POCD (103.37ng/L) and non-POCD (7.38 ng/L) (p<0.001). Patients that experienced POCD had significantly increased S100B compared to those who did not.\\nConclusion: There is a correlation between changes of S100B levels and the incidence of POCD in patients undergoing ENT surgeries with controlled hypotension.\",\"PeriodicalId\":44369,\"journal\":{\"name\":\"Bali Medical Journal\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.9000,\"publicationDate\":\"2022-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Bali Medical Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.15562/bmj.v11i3.3847\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bali Medical Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.15562/bmj.v11i3.3847","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0

摘要

导言:控制低血压是应用于几种显微镜耳鼻喉(ENT)手术的技术之一。然而,这种技术有风险和并发症,会导致包括大脑在内的器官灌注和氧合受损,从而引发术后认知功能障碍(POCD)。发生在脑细胞的损伤可以触发血液中生物标志物蛋白的分泌,其中一种是S100B,它可以在术中和术后期间指示神经损伤。本研究旨在分析耳鼻喉科手术患者控制低血压患者S100B蛋白水平与POCD发生率的相关性。方法:对2022年7月至8月在泗水Dr. Soetomo综合学术医院接受选择性耳鼻喉手术的患者进行横断面研究。术前12小时、术后2小时和24小时采用简易精神状态检查(MMSE)评估认知功能。术前12小时和术后30分钟采用酶联免疫吸附试验(ELISA)检测S100B水平。结果:研究共招募了31例患者,平均年龄为31.7岁。POCD患者术前和术后平均S100B水平分别为311.97 ng/L和415.34 ng/L。在非pocd患者中,术前和术后S100B的平均水平分别为436.90 ng/L和444.29 ng/L。3例(9.7%)出现POCD。我们的数据显示,POCD患者组术前和术后S100B水平差异有统计学意义(103.37ng/L)和非POCD患者组(7.38 ng/L) (p<0.001)。与未经历POCD的患者相比,经历POCD的患者S100B显著增加。结论:在控制低血压的耳鼻喉外科患者中,S100B水平的变化与POCD的发生有相关性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Correlation of S100B level and postoperative cognitive dysfunction (POCD) events among patients with ear, nose and throat (ENT) surgeries with controlled hypotension
Introduction: Controlled hypotension is one of the techniques applied to several microscopic ear, nose, and throat (ENT) surgeries. However, this technique has risks and complications, which result in impaired perfusion and oxygenation of organs including the brain that could trigger the postoperative cognitive dysfunction (POCD). Damage that occurs in brain cells can trigger the secretion of biomarker proteins in the blood, one of which is S100B which can indicate nerve damage in the intra and postoperative period. This study aimed to analyze the correlation between S100B protein level and the incidence of POCD in patients who received ENT surgeries with controlled hypotension. Methods: A cross-sectional study was conducted among patients that underwent elective ENT surgeries at Dr. Soetomo General Academic Hospital, Surabaya, from July to August 2022. Cognitive function was assessed using Mini-mental State Examination (MMSE) at 12 hours before and 2 and 24 hours after surgery. The level of S100B was measured using enzyme-linked immunosorbent assay (ELISA) 12 hours prior surgery and 30 minutes post-surgery. Results: A total of 31 patients were recruited in the study, including a mean age of 31.7 years. The mean S100B levels in POCD patients pre- and postoperative were 311.97 ng/L, and 415.34 ng/L, respectively. In non-POCD patients, the mean levels of S100B pre and postoperative were 436.90 ng/L, and 444.29 ng/L, respectively. There were 3 (9.7%) patients experienced POCD. Our data suggested there was a significant difference between preoperative and postoperative S100B levels in the groups of patients with POCD (103.37ng/L) and non-POCD (7.38 ng/L) (p<0.001). Patients that experienced POCD had significantly increased S100B compared to those who did not. Conclusion: There is a correlation between changes of S100B levels and the incidence of POCD in patients undergoing ENT surgeries with controlled hypotension.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Bali Medical Journal
Bali Medical Journal MEDICINE, GENERAL & INTERNAL-
自引率
50.00%
发文量
8
审稿时长
3 weeks
期刊最新文献
Supporting the Recovery of Travel Agencies in Bali through Softloan Menelisik Perkembangan PAD Kabupaten Buleleng Pascapandemi Covid-19 Makna Bentuk dan Aksara Rerajahan Callaccitra Undagi Mahottama: A Documentary Film on “Undagi” Bali as a Cultural Heritage Digital Repository Content The Function and Meaning of "Kulkul" in Balinese Society: A Case Study in Batuaji Kawan Traditional Village, Tabanan (A Cultural Linguistics Review)
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1