控制低血压的耳鼻喉手术患者S100B水平与术后认知功能障碍(POCD)事件的相关性

IF 0.9 Q3 MEDICINE, GENERAL & INTERNAL Bali Medical Journal Pub Date : 2022-12-01 DOI:10.15562/bmj.v11i3.3847
Boby Abdul Rahman, P. Airlangga, Andy Nauman Saputra, Prihatma Kriswidyatomo, Agustina Salinding, Hamzah, Maulidya, Muhtarum Yusuf
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引用次数: 0

摘要

导言:控制低血压是应用于几种显微镜耳鼻喉(ENT)手术的技术之一。然而,这种技术有风险和并发症,会导致包括大脑在内的器官灌注和氧合受损,从而引发术后认知功能障碍(POCD)。发生在脑细胞的损伤可以触发血液中生物标志物蛋白的分泌,其中一种是S100B,它可以在术中和术后期间指示神经损伤。本研究旨在分析耳鼻喉科手术患者控制低血压患者S100B蛋白水平与POCD发生率的相关性。方法:对2022年7月至8月在泗水Dr. Soetomo综合学术医院接受选择性耳鼻喉手术的患者进行横断面研究。术前12小时、术后2小时和24小时采用简易精神状态检查(MMSE)评估认知功能。术前12小时和术后30分钟采用酶联免疫吸附试验(ELISA)检测S100B水平。结果:研究共招募了31例患者,平均年龄为31.7岁。POCD患者术前和术后平均S100B水平分别为311.97 ng/L和415.34 ng/L。在非pocd患者中,术前和术后S100B的平均水平分别为436.90 ng/L和444.29 ng/L。3例(9.7%)出现POCD。我们的数据显示,POCD患者组术前和术后S100B水平差异有统计学意义(103.37ng/L)和非POCD患者组(7.38 ng/L) (p<0.001)。与未经历POCD的患者相比,经历POCD的患者S100B显著增加。结论:在控制低血压的耳鼻喉外科患者中,S100B水平的变化与POCD的发生有相关性。
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Correlation of S100B level and postoperative cognitive dysfunction (POCD) events among patients with ear, nose and throat (ENT) surgeries with controlled hypotension
Introduction: Controlled hypotension is one of the techniques applied to several microscopic ear, nose, and throat (ENT) surgeries. However, this technique has risks and complications, which result in impaired perfusion and oxygenation of organs including the brain that could trigger the postoperative cognitive dysfunction (POCD). Damage that occurs in brain cells can trigger the secretion of biomarker proteins in the blood, one of which is S100B which can indicate nerve damage in the intra and postoperative period. This study aimed to analyze the correlation between S100B protein level and the incidence of POCD in patients who received ENT surgeries with controlled hypotension. Methods: A cross-sectional study was conducted among patients that underwent elective ENT surgeries at Dr. Soetomo General Academic Hospital, Surabaya, from July to August 2022. Cognitive function was assessed using Mini-mental State Examination (MMSE) at 12 hours before and 2 and 24 hours after surgery. The level of S100B was measured using enzyme-linked immunosorbent assay (ELISA) 12 hours prior surgery and 30 minutes post-surgery. Results: A total of 31 patients were recruited in the study, including a mean age of 31.7 years. The mean S100B levels in POCD patients pre- and postoperative were 311.97 ng/L, and 415.34 ng/L, respectively. In non-POCD patients, the mean levels of S100B pre and postoperative were 436.90 ng/L, and 444.29 ng/L, respectively. There were 3 (9.7%) patients experienced POCD. Our data suggested there was a significant difference between preoperative and postoperative S100B levels in the groups of patients with POCD (103.37ng/L) and non-POCD (7.38 ng/L) (p<0.001). Patients that experienced POCD had significantly increased S100B compared to those who did not. Conclusion: There is a correlation between changes of S100B levels and the incidence of POCD in patients undergoing ENT surgeries with controlled hypotension.
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来源期刊
Bali Medical Journal
Bali Medical Journal MEDICINE, GENERAL & INTERNAL-
自引率
50.00%
发文量
8
审稿时长
3 weeks
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