利用逆转录病毒和慢病毒载体提供新的基因疗法

Alex, R. Gonçalves
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引用次数: 1

摘要

提交手稿|http://medcraveonline.com不同个体的变异,以评估其与遗传特征的关系和病理后果。研究人员认识到,观察到的个体和遗传特征之间的遗传异质性对开发新的治疗方法构成了巨大的挑战。有了这种新的个性化医学信息方法,基因工程的进展很快就开始尝试并帮助解决遗传异常。了解观察到的功能性遗传多样性有助于将病理表型与对治疗的特异性反应联系起来。找到致病基因突变对于确定纠正基因缺陷的精确策略至关重要。逆转录病毒和慢病毒很快被认为是利用病毒入侵和利用宿主基因组的机制来操纵人类基因组的可行方法。
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Use of Retroviral and Lentiviral Vectors to Deliver New Gene Therapies
Submit Manuscript | http://medcraveonline.com variants in different individuals to assess its association with a genetic trait and the pathological consequences. Researchers recognized that the observed genetic heterogeneity amongst individuals and genetic traits constitutes a Herculean challenge to develop new treatments. With this new personalized medicine information approach, the advance in genetic engineering was fast to act to try and help solving genetic abnormalities. Understanding the observed functional genetic diversity helps to correlate pathology phenotypes with the specific responses to therapeutic treatments. Finding the causal genetic mutations is crucial to define a precise strategy to correct the genetic imperfection. Retroviruses and lentiviruses were soon considered a viable approach to manipulate the human genome taking advantage of the mechanisms viruses use to invade and exploit the host genome.
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