肥胖和超重儿童甲状腺功能和代谢参数的评估:一项前瞻性病例对照研究。

IF 0.1 4区 医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Investigacion clinica Pub Date : 2022-05-31 DOI:10.54817/ic.v63n2a02
Ayşe Tuğba Kartal, A. Bozaykut, Rabia Gönül Sezer, T. Güran
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引用次数: 0

摘要

肥胖被认为是一项重要的全球公共卫生挑战,其在儿童中的患病率正在迅速上升。在这项研究中,我们调查了正常TSH水平是否与代谢综合征参数有关,包括肥胖、高血压、血脂异常以及超重和肥胖儿童胰岛素敏感性的变化。我们还调查了BMI和这些参数之间是否存在关系。这项前瞻性病例对照研究包括145名5-18岁的参与者(74名女性,71名男性)。根据BMI z评分,参与者被分为三组,分别为超重组、肥胖组和对照组。对照组包括35名年龄和性别匹配的健康受试者。对照组、超重组和肥胖组的促甲状腺激素水平分别为2.14±1.27、2.97±1.26和3.13±1.11(p<0.05),TSH与BMI、BMI z评分呈显著正相关(r=0.302,p=0.000),(r=0.121,p=0.004)。目前的研究表明,超重和肥胖儿童血清TSH水平的升高,即使在正常范围内,也与代谢参数的损害有关,包括血脂异常和胰岛素敏感性。因此,TSH水平在高正常范围内应被视为代谢综合征及其成分的危险因素。
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Evaluation of thyroid function and metabolic parameters in obese and overweight children: A prospective case-control study.
Obesity is considered an important global public health challenge, and its prevalence is rapidly increasing in children. We investigated in this study if the upper-normal TSH level may be associated with metabolic syndrome parameters, including obesity, high blood pressure, and dyslipidemia and changes in insulin sensitivity in overweight and obese children. We also investigated whether there is a relationship between BMI and these parameters. This prospective case-control study comprised 145 participants (74 females, 71 males) aged 5–18 years. Participants were divided into three groups according to their BMI z-score, as overweight, obese and control. The control group included 35 age and sex-matched healthy subjects. Thyroid stimulating hormone levels of control, overweight and obese groups were 2.14 ± 1.27, 2.97 ± 1.26 and 3.13 ± 1.11, respectively (p<0.05). There was a significant positive correlation between TSH and the BMI, BMI z-scores between overweight and obese groups (r=0.302, p=0.000), (r=0.121, p=0.004), respectively. The current study suggests that increased serum TSH levels, even within the normal range, in overweight and obese children is associated with the impairment of metabolic parameters, including dyslipidemia and insulin sensitivity. For that reason, TSH levels in the high-normal range should be considered as a risk factor for metabolic syndrome and its components.
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来源期刊
Investigacion clinica
Investigacion clinica MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
0.20
自引率
50.00%
发文量
2
审稿时长
>12 weeks
期刊介绍: Estudios humanos, animales y de laboratorio relacionados con la investigación clínica y asuntos conexos.
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