评估啮齿类动物、非人类灵长类动物和人类的行为和认知:翻译的极限在哪里?

IF 8.3 2区 医学 Q1 Medicine Dialogues in Clinical Neuroscience Pub Date : 2019-09-01 DOI:10.31887/DCNS.2019.21.3/mrossner
M. Stephan, Paul Volkmann, M. Rossner
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引用次数: 18

摘要

情感性和非情感性精神病需要新的精神药理学治疗,特别是相关的阴性和认知症状。早期的开发大多失败了,部分原因可能是用于验证的行为模型的局限性。现在,随着对疾病发病机制的遗传学的深入了解和基因工程的进展,将产生许多结构效度更高的啮齿动物模型。为了提高这些模型的翻译价值,我们需要来自非人类灵长类动物的补充数据。我们还必须改进和简化行为测试系统,以应对日益增长的需求。在这里,我们提出了一个全面的神经认知测试电池,它应该克服单一测试的缺点,并产生用于建模患者症状子集的认知/行为概况。此外,我们描述了一种分类疾病相关认知内表型的概念,以平衡面部和结构有效性和临床诊断。综上所述,本文讨论了精神病学认知转化研究的新概念、局限性和未来潜力。
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Assessing behavior and cognition in rodents, nonhuman primates, and humans: where are the limits of translation?

New psychopharmacological treatments are needed for affective and nonaffective psychoses, especially for the associated negative and cognitive symptoms. Earlier developments mostly failed, probably partly because of limitations in behavioral models used for validation. Now, deeper understanding of the genetics underlying disease pathogenesis and progress in genetic engineering will generate many rodent models with increased construct validity. To improve these models’ translational value, we need complementary data from nonhuman primates. We also have to improve and streamline behavioral test systems to cope with increased demand. Here, we propose a comprehensive neurocognitive test battery that should overcome the disadvantages of single tests and yield cognitive/behavioral profiles for modeling subsets of patient symptoms. Further, we delineate a concept for classifying disease-relevant cognitive endophenotypes to balance between face and construct validity and clinical diagnostics. In summary, this review discusses new concepts and the limitations and future potential of translational research on cognition in psychiatry.

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来源期刊
Dialogues in Clinical Neuroscience
Dialogues in Clinical Neuroscience Medicine-Psychiatry and Mental Health
CiteScore
19.30
自引率
1.20%
发文量
1
期刊介绍: Dialogues in Clinical Neuroscience (DCNS) endeavors to bridge the gap between clinical neuropsychiatry and the neurosciences by offering state-of-the-art information and original insights into pertinent clinical, biological, and therapeutic aspects. As an open access journal, DCNS ensures accessibility to its content for all interested parties. Each issue is curated to include expert reviews, original articles, and brief reports, carefully selected to offer a comprehensive understanding of the evolving landscape in clinical neuroscience. Join us in advancing knowledge and fostering dialogue in this dynamic field.
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