COVID-19 SIR模型的延迟动力学

H. Ebraheem, Nizar J. Alkhateeb, H. Badran, A. Hajjiah, Ebraheem Sultan
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引用次数: 6

摘要

COVID-19大流行的全球传播是自1918年上次大流行爆发以来世界面临的最具挑战性的任务之一。早期,各国感到病毒感染传播的强度和持久性,无法估计传播速度。受感染国家的官员遵循了世界卫生组织(WHO)制定的几项指导方针,试图使感染曲线趋于平缓,并保持低感染人数。尽管如此,病毒仍在肆无忌惮地传播,到目前为止,所有关于控制措施或检测高峰的预测都是失败的。因此,需要一个更准确的模型来预测感染的高峰,并帮助指导官员从世界卫生组织概述的众多选择中制定最佳的公共卫生安全措施。早期对易感-感染-恢复(SIR)区室模型的研究不能预测病毒感染热点的峰值,需要一个新的模型来提供更现实的结果,以服务于全球抗击大流行的政府官员。方法一种新的改进SIR模型,该模型纳入了适当的延迟参数,可以更精确地预测COVID-19实时数据。新模型的预测结果与德国、意大利、科威特和阿曼四个国家的实际数据进行了比较。SIR模型中包含的两个潜伏期和恢复延迟期产生了对实时数据的合理和更准确的表示。传染病例的恢复时间延迟𝜏2的值定义模型的繁殖数𝑅0。结果结合与COVID-19的潜伏期和恢复期相对应的两个延迟期,可以更准确地预测每个地理区域的大流行感染高峰。模型中参数的变化,如:时延、、时延、𝜏1、𝑎𝑛𝑑𝜏2,对应不同的情况构成不同的情况。这些变化是根据观察到的情况和在受感染地区收集的数据进行先验估计的,以便为官员提供更好的指导方针,指导未来应该制定哪些卫生政策。WHO提供的实证数据表明,本文提出的新SIR模型能够更好、更准确地预测COVID-19大流行传播曲线。该模型与四个国家的实时数据非常吻合。仿真结果与数据一致,生成的曲线约束良好。这些参数可以改变和调整,以便在每个国家的范围内编制和(或)复制数字
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Delayed Dynamics of SIR Model for COVID-19
BackgroundThe global spread of the COVID-19 pandemic has been one of the most challenging tasks the world has faced since the last pandemic outbreak of 1918. Early on countries felt the strength and persistence of the virus infections spreading with no means of estimating the dispersion rates. Officials in infected countries followed several guidelines set by the World Health Organization (WHO) to try and flatten the infection curve and maintain a low number of infectives. Nonetheless, the virus kept on spreading with impunity and all predictions of how containments or peak detections have been a fail so far. Therefore, a need for a more accurate model to predict the peaking of infections and help guide officials on what best to enact as a measure of public health safety from a multitude of choices outlined by the WHO. Earlier studies of compartmental model of Susceptible-Infected-Recovered (SIR) did not predict the peaking of a hot spots flairs of viral infections and a new model needed to provide a more realistic results to serve public officials battling the pandemic worldwideMethodsA new modified SIR model which incorporates appropriate delay parameters leading to a more precise prediction of COVID-19 real time data. The predictions of the new model are compared to real data obtained from four countries, namely Germany, Italy, Kuwait, and Oman. Two included delay periods for incubation and recovery within the SIR model produces a sensible and more accurate representation of the real time data. The reproductive number 𝑅0 is defined for the model for values of recovery time delay 𝜏2 of the infective case.ResultsIncorporating two delay periods that corresponds to the duration of the incubational and recovery periods measured for COVID-19 gives a more accurate prediction of the peak pandemic infections per geographical area. The parameter variations in the model 𝛽,𝛾,𝛼,𝜏1,𝑎𝑛𝑑 𝜏2 makeup different cases corresponding to different situations. The variations are estimated a priori based on what is being observed and collected data of an infected region to give officials better guidelines on what health policies should be enacted in the future.2 of 15ConclusionsThe empirical data provided by WHO show that the proposed new SIR model gives a better more accurate prediction of COVID-19 pandemic spreading curve. The model is shown to closely fit real time data for four countries. Simulation results are consistent with data and generated curves are well constrained. The parameters can be varied and adjusted for producing and/or reproduction of numbers within the range of each country
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