Toll样受体在代谢综合征中的表达:系统综述

M. Mahdavi, Z. Fallah, R. Kelishadi
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引用次数: 2

摘要

引言:先天免疫系统的Toll样受体(TLRs)已被证明在代谢紊乱的发病机制中发挥作用。本研究旨在系统综述TLRs在代谢综合征(MetS)中的表达。材料和方法:我们系统地搜索了PubMed/Medline、ISI科学网、Scopus、Google Scholar、EMBASE和OVID数据库,直到2017年2月。使用术语“代谢综合征”或“Mets”和“类甲状腺受体”或“类甲状腺激素”或“甲状腺激素或”。在我们的搜索中没有特意使用“Expression”,而是在选择过程中进行了考虑。对文章进行了三个选择步骤,然后对其进行鉴定。结果:首先,在国际数据库中发现1373篇文章。去除重复后,剩下963篇论文,经过两步筛选,这一数字分别达到410篇和27篇。经过全文筛选和鉴定过程,我们最终纳入了13篇文章,包括5项动物研究和8项人类研究。所有人类研究都报告了MetS中TLRs(2、4、5、9型)的过度表达,大多数动物研究都记录了TLRs表达的增加。结论:本系统综述为先天免疫系统与代谢综合征的关系提供了证据。其关于MetS中特殊TLR(如2、4、5、9型)过表达的发现及其基本机制和临床意义可能会在进一步的研究中进行研究。
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Expression of Toll-Like receptors in metabolic syndrome: A systematic review
Introduction: Toll-Like Receptors (TLRs) of innate immune system have documented roles in the pathogenesis of metabolic disorders. This study aims to systematically review the expression of TLRs on metabolic syndrome (MetS). Materials and methods: We systematically searched PubMed/Medline, ISI web of Science, Scopus, Google Scholar, EMBASE, and OVID databases until February 2017. The terms ‘‘Metabolic Syndrome OR ‘‘Mets AND ‘‘Toll like receptor OR ‘‘Toll like OR ‘‘TLRs OR ‘‘TLR were used. “Expression” advertently was not used in our search and was considered in the selection process. Three steps for selecting the articles and then their qualification were conducted. Results: First, 1373 articles were found in the international databases. After removing duplicates, 963 papers remained and after two steps of selection, this number reached 410 and then 27, respectively. After full text screening and qualifying processes, we finally included 13 articles consisting of five animal and eight human studies. All human studies reported overexpression of TLRs (types 2, 4, 5, 9) in MetS, and most animal studies documented an increased TLRs expression. Conclusion: This systematic review provides evidence for the relation of innate immune system with MetS. Its findings regarding overexpression of special TLRs (e.g. types 2, 4, 5, 9) in MetS and their basic mechanisms and clinical implications might be investigated in further studies.
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