混合d -最优法测定可可壳提取液发胶的凝胶结构特征

Q4 Biochemistry, Genetics and Molecular Biology International Journal of Biology and Biomedical Engineering Pub Date : 2022-01-10 DOI:10.46300/91011.2022.16.14
Arief Huzaimi Md Yusof, Siti Salwa Abd Gani, Uswatun Hasanah Zaidan, M. Halmi
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引用次数: 0

摘要

本研究采用混合物设计来优化含有可可壳提取物的局部发胶的铺展性和粘度。头发凝胶成分的因素是增稠剂(0.2-0.8%)、定型聚合物A(2-5%)、定型聚合物B(2-6%)和溶剂(84.63-91.63%)。所收集的数据与具有高系数测定的模型拟合(铺展性R2=0.994,粘度R2=0.9937)。该模型可以通过显示良好的不匹配测试结果来预测,p值大于0.05时不显著。从斜坡函数模拟中,选择并确定了增稠剂(0.55%)、定型聚合物A(3.61%)、定型聚合物B(3.72%)和溶剂(88.55%)的最佳配方,其铺展性和粘度分别为353.77g.s和39.91pa.s。在本实验中使用混合物设计的好处是,它可以帮助公式制定者了解因素之间的复杂相互作用,并可以通过斜坡函数模拟轻松地修改公式,以获得所需的结果。预测验证测试表明,这两个值具有可比性。在此条件下,模型开发可用于预测未来在增稠剂(0.2–0.8%)、定型聚合物A(2-5%)、定型聚合物B(2-6%)和溶剂(84.63–91.63%)设计范围内的观测结果。
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Gel Textural Characteristics of Hair Gel with Cocoa Shell Extract by Using Mixture D-optimal Method
This study was used a mixture design to optimize the spreadability and viscosity of topical hair gel incorporates cocoa shell extract. The factor of the hair gel ingredient was thickener (0.2 – 0.8%), styling polymer A (2-5%), styling polymer B (2-6%), and solvent (84.63-91.63%) were studied on two responses selected spreadability and viscosity. The data collected were fitted to the model with high coefficient determination (R2= 0.994 for the spreadability and 0.9937 for the viscosity). The model can be predicted by showing the good lack of fit test result not significant with the p-value bigger than 0.05. From the ramp function simulation, the optimized formulation was selected and established at thickener (0.55%), styling polymer A (3.61%), styling polymer B (3.72%), and solvent (88.55%) with the spreadability and viscosity at 353.77 g.s and 39.91 pa.s respectively. The benefit of using mixture design in this experiment, it can help a formulator to understand the complex interaction between factors and can easily modify the formulation through ramp function simulation to obtain the desired result. The predicted validation test shows that both values were comparable. Under this condition showed that the model development could be used to predict future observations within the design range thickener (0.2 – 0.8%), styling polymer A (2-5%), styling polymer B (2-6%), and solvent (84.63-91.63%).
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来源期刊
International Journal of Biology and Biomedical Engineering
International Journal of Biology and Biomedical Engineering Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)
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期刊介绍: Topics: Molecular Dynamics, Biochemistry, Biophysics, Quantum Chemistry, Molecular Biology, Cell Biology, Immunology, Neurophysiology, Genetics, Population Dynamics, Dynamics of Diseases, Bioecology, Epidemiology, Social Dynamics, PhotoBiology, PhotoChemistry, Plant Biology, Microbiology, Immunology, Bioinformatics, Signal Transduction, Environmental Systems, Psychological and Cognitive Systems, Pattern Formation, Evolution, Game Theory and Adaptive Dynamics, Bioengineering, Biotechnolgies, Medical Imaging, Medical Signal Processing, Feedback Control in Biology and Chemistry, Fluid Mechanics and Applications in Biomedicine, Space Medicine and Biology, Nuclear Biology and Medicine.
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