Comparison of clinical parameters between the treatment of infrabony defects with and without concentrated growth factors in open flap debridement: In vivo study

Introduction: This study aimed to clinically and radiographically compare the regenerative effects of open flap debridement alone and in combination with concentrated growth factor (CGF) in the treatment of periodontal three-walled infrabony defects. Materials and Methods: Fifteen patients who fulfilled the inclusion criteria were selected from the outpatient department of periodontology. A split-mouth study was conducted and bilateral or contralateral defects were divided into two groups using computer-generated randomisation sheets-control site (open flap debridement alone) and case site (open flap debridement with CGF). Clinical parameters were assessed at baseline, 1 month, 3 months and 6 months. Radiographic parameters were assessed at baseline and 6 months postoperatively. Results: At 3 and 6 months postoperatively, the test group showed statistically significant improvement in clinical parameters as compared to the control group. At 6 months postoperatively, the test group showed improved bone fill as compared to the control group. Conclusion: Present study indicates that CGF, as a biological material has the property to enhance wound healing and result in mean pocket depth reduction of periodontal infrabony defects. In addition, long-term, multicentered randomised, controlled clinical researches will be required to better understand the clinical and radiographic effects of CGF on periodontal regeneration.