妊娠期糖尿病后的避孕选择:当前展望

IF 1.8 Q3 OBSTETRICS & GYNECOLOGY Open access journal of contraception Pub Date : 2019-10-01 DOI:10.2147/OAJC.S184821
A. Turner, Emily A. Donelan, Jessica W. Kiley
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引用次数: 2

摘要

摘要妊娠期糖尿病(GDM)使美国约7%的妊娠复杂化。除了与妊娠相关的风险因素外,有GDM病史的女性在以后的生活中患2型糖尿病的风险也会增加。在讨论避孕和其他生殖健康问题时,需要特别考虑这些妇女。GDM在美国所有避孕方法的医疗资格标准中都属于1类,该标准支持各种方法的安全性,但不考虑有效性。避孕选择的成分和作用机制各不相同,人们对避孕可能对新陈代谢产生的影响表示担忧。临床证据仅限于表明激素避孕对体重、脂质或葡萄糖代谢有显著不利影响。此外,大多数证据并不表明2型糖尿病的发展与激素避孕的使用之间存在关系。数据有限,因此对有GDM病史的女性提出广泛、一般的避孕建议具有挑战性。在进行避孕咨询时,应考虑女性的GDM病史。讨论应集中在潜在的医学合并症和GDM对未来健康的影响上,特别考虑骨骼健康、肥胖、心血管疾病和血栓风险等问题。提供者必须强调GDM妇女可靠、高效避孕的重要性,以优化未来怀孕的时间。这种综合咨询方法将指导避孕药具使用、生活方式改变和后续妊娠计划的最佳决策。
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Contraceptive Options Following Gestational Diabetes: Current Perspectives
Abstract Gestational diabetes mellitus (GDM) complicates approximately 7% of pregnancies in the United States. Along with risk factors related to pregnancy, women with a history of GDM also have an increased risk of developing type 2 diabetes mellitus later in life. These women require special consideration when discussing contraception and other reproductive health issues. GDM carries a category 1 rating in the US Medical Eligibility Criteria for all contraceptive methods, which supports safety of the various methods but does not account for effectiveness. Contraceptive options differ in composition and mechanisms of action, and concerns have been raised about possible effects of contraception on metabolism. Clinical evidence is limited to suggest that hormonal contraception has significantly adverse effects on body weight, lipid, or glucose metabolism. In addition, the majority of evidence does not suggest a relationship between development of type 2 diabetes mellitus and use of hormonal contraception. Data are limited, so it is challenging to make a broad, general recommendation regarding contraception for women with a history of GDM. A woman’s history of GDM should be considered during contraceptive counseling. Discussion should focus on potential medical comorbidities and the implications of GDM on future health, with special consideration of issues including bone health, obesity, cardiovascular disease, and thrombosis risk. Providers must emphasize the importance of reliable, highly effective contraception for women with GDM, to optimize the timing of future pregnancies. This approach to comprehensive counseling will guide optimal decision-making on contraceptive use, lifestyle changes, and planning of subsequent pregnancies.
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