ESRS、FIB、Hcy和卒中史升高是PAIS的独立危险因素

IF 0.5 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Pteridines Pub Date : 2018-11-01 DOI:10.1515/pteridines-2018-0014
Tao Zhang, Huiyun Li, Ling Li, Faying Zhou
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The prediction sensitivity, specificity and area under the ROC curve (AUC) of serum Hcy and ESRS for PAIS were calculated using STATA11.0 software. Results: The elevated ESRS (OR=1.82, p<0.05), serum fibrinogen (FIB) (OR=1.18, p<0.05), Hcy (OR=1.21, p<0.05) and personal stroke history (OR=1.74, p<0.05) were independent risk factors for PAIS. The serum Hcy of the PAIS and NPAIS groups were 24.59±9.24 (μmol/L) and 18.20±8.29 (μmol/L) respectively with a statistical significance of p<0.05. The ESRS were 3.43±1.09 and 2.60±0.92 for the PAIS and NPAIS groups respectively, with a significance of p<0.05. The prediction sensitivity, specificity and AUC were 76.24%, 67.74% and 0.73 (95%CI:0.63-0.83), respectively, for serum Hcy. For ESRS, the prediction sensitivity, specificity and AUC were 69.99%, 64.52% and 0.74 (95%CI:0.63-0.84) respectively. Correlation between serum Hcy and ESRS was evaluated by a Pearson correlation test. 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引用次数: 2

摘要

背景:本研究旨在探讨血清同型半胱氨酸(Hcy)和Essen卒中风险评分(ESRS)在预测进展性急性缺血性卒中(PAIS)中的诊断作用。方法回顾性收集2016年2月~ 2018年1月第三军医大学大坪医院急性缺血性脑卒中(AIS)患者132例。将132例AIS患者按照PAIS的定义分为PAIS组和非进展性AIS (NPAIS)组。比较PAIS组和NPAIS组的临床特征、血清Hcy浓度和ESRS。采用logistic回归分析评价PAIS的独立危险因素。采用STATA11.0软件计算血清Hcy和ESRS对PAIS的预测敏感性、特异性和ROC曲线下面积(AUC)。结果:ESRS升高(OR=1.82, p<0.05)、血清纤维蛋白原(FIB)升高(OR=1.18, p<0.05)、Hcy升高(OR=1.21, p<0.05)、个人卒中史升高(OR=1.74, p<0.05)是PAIS的独立危险因素。PAIS组和NPAIS组血清Hcy分别为24.59±9.24 (μmol/L)和18.20±8.29 (μmol/L),差异均有统计学意义(p<0.05)。PAIS组和NPAIS组的ESRS分别为3.43±1.09和2.60±0.92,差异均有统计学意义(p<0.05)。预测血清Hcy的敏感性为76.24%,特异性为67.74%,AUC为0.73 (95%CI:0.63 ~ 0.83)。ESRS的预测敏感性为69.99%,特异性为64.52%,AUC为0.74 (95%CI:0.63-0.84)。采用Pearson相关检验评价血清Hcy与ESRS的相关性。PAIS患者血清Hcy与ESRS呈显著正相关(r=0.54, p<0.05), NPAIS患者血清Hcy与ESRS呈显著正相关(r=0.78, p<0.01)。结论:ESRS、血清FIB、Hcy和卒中史升高的患者发生PAIS的风险增高。
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Elevated ESRS, serum FIB, Hcy and stroke history were independent risk factors to PAIS
Abstract Background: The aim of this study was to investigate the diagnostic performance of serum homocysteine (Hcy) and Essen stroke risk score (ESRS) in prediction of progressing acute ischemic stroke (PAIS). Methods One hundred and thirty two acute ischemic stroke (AIS) patients were retrospectively recruited from Daping Hospital, Third Military Medical University from February 2016 to January 2018. The 132 AIS patients were divided into PAIS and non-progressing AIS (NPAIS) groups according to the definition of PAIS. The clinical characteristics, serum Hcy concentration, and ESRS were compared between the PAIS and NPAIS groups. The independent risk factors for PAIS were evaluated by logistic regression analysis. The prediction sensitivity, specificity and area under the ROC curve (AUC) of serum Hcy and ESRS for PAIS were calculated using STATA11.0 software. Results: The elevated ESRS (OR=1.82, p<0.05), serum fibrinogen (FIB) (OR=1.18, p<0.05), Hcy (OR=1.21, p<0.05) and personal stroke history (OR=1.74, p<0.05) were independent risk factors for PAIS. The serum Hcy of the PAIS and NPAIS groups were 24.59±9.24 (μmol/L) and 18.20±8.29 (μmol/L) respectively with a statistical significance of p<0.05. The ESRS were 3.43±1.09 and 2.60±0.92 for the PAIS and NPAIS groups respectively, with a significance of p<0.05. The prediction sensitivity, specificity and AUC were 76.24%, 67.74% and 0.73 (95%CI:0.63-0.83), respectively, for serum Hcy. For ESRS, the prediction sensitivity, specificity and AUC were 69.99%, 64.52% and 0.74 (95%CI:0.63-0.84) respectively. Correlation between serum Hcy and ESRS was evaluated by a Pearson correlation test. Significant positive correlation between serum Hcy and ESRS was found in PAIS (r=0.54, p<0.05), and NPAIS patients (r=0.78, p<0.01). Conclusion: Patients with elevated ESRS, serum FIB, Hcy and stroke history had an elevated risk of developing PAIS.
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来源期刊
Pteridines
Pteridines 生物-生化与分子生物学
CiteScore
1.20
自引率
25.00%
发文量
6
审稿时长
>12 weeks
期刊介绍: Pteridines is an open acess international quarterly journal dealing with all aspects of pteridine research. Pteridines are heterocyclic fused ring compounds involved in a wide range of biological functions from the color on butterfly wings to cofactors in enzyme catalysis to essential vitamins. Of the pteridines, 5,6,7,8-tetrahydrobiopterin is the necessary cofactor of several aromatic amino acid monoxygenases, the nitric oxide synthases and glyceryl ether monoxygenase (GEMO). Neopterin plays an essential role in the immune system and is an important biomarker in laboratory medicine for diseases such as HIV, cardiovascular disease, malignant tumors, among others. Topics: -Neopterin, dihydroneopterin, monapterin- Biopterin, tetrahydrobiopterin- Folates, antifolates, riboflavin- Phenylalanine, tyrosine, phenylketonuria, serotonin, adrenalin, noradrenalin, L-DOPA, dopamine, related biogenic amines- Phenylalanine hydroxylase, tyrosine hydroxylase, tryptophan hydroxylase, nitric oxide synthases (iNOS), alkylglycerol monooxygenase (AGMO), dihydropterin reductase, sepiapterin reductase- Homocysteine, mediators of inflammation, redox systems, iron.
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