中药生物活性胶囊化纳米制剂治疗胃癌:简要综述

IF 2.5 4区 材料科学 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY Nano Futures Pub Date : 2023-09-08 DOI:10.1088/2399-1984/acf822
Arya Rai̇, Simrandeep Kaur, S. Rawat, Inderbir Singh
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引用次数: 0

摘要

癌症是全球死亡的主要原因。导致其发展的主要风险因素包括年龄、幽门螺杆菌感染、过量摄入盐以及饮食中缺乏水果和蔬菜。它是通过超声波、CT扫描、内镜活检和某些生物标志物的检测来诊断的。癌症的常规治疗方法包括放射治疗、手术切除和化疗。然而,这些治疗存在一些主要问题,如肿瘤复发风险高、耐药性发展、药物在靶点的生物利用度低、药物代谢快以及药物剂量引起的高全身毒性。使用草药生物活性物质可以克服传统治疗的所有这些局限性,因为它们对正常健康细胞的毒性较小,并降低了肿瘤复发和耐药性发展的风险。开发纳米制剂是为了帮助靶向药物递送,并提高植物成分的溶解度、稳定性、生物利用度和治疗效果。随着纳米材料的出现,不同的成像模式被整合到一个单一的平台中,并建立了对癌症具有协同效应的联合疗法。此外,多功能纳米颗粒促进了具有同时诊断和治疗能力的诊断策略的发展。本文就癌症的死亡率、长期趋势、病理生理学、病因、危险因素、诊断、预后等方面进行综述,以及不同的治疗方法,主要侧重于草药生物活性物质(槲皮素、紫杉醇、白藜芦醇、姜黄素和人参皂苷)和不同的草药成分包封的纳米制剂(如纳米颗粒、niosomes、脂质体、纳米乳液和胶束)。草药生物活性包封纳米制剂用于治疗/管理胃癌的挑战和未来前景已包含在手稿的后面部分。
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Herbal bioactive encapsulated nano-formulations for the treatment of gastric cancer: a concise review
Gastric cancer is a prominent cause of death globally. The major risk factors responsible for its development include age, H. pylori infection, excessive salt intake, and lack of fruits and vegetables in the diet. It is diagnosed using ultrasound, CT scan, endoscopic biopsy, and by detection of certain biomarkers. The conventional therapies for treatment of gastric cancer include the use of radiations, surgical resection, and chemotherapy. However, there are certain major issues associated with these treatments, like high risk of tumour reoccurrence, drug resistance development, less bioavailability of the drug at target site, rapid drug metabolism and high systemic toxicity due to drug doses. All such limitations of conventional treatments can be overcome with the use of herbal bio-actives as they exhibit less toxicity to normal healthy cells and reduce the risk of tumour recurrence and resistance development. Nano-formulations are developed to aid in targeted drug delivery, and to enhance the solubility, stability, bioavailability, and therapeutic efficacy of phytoconstituents. With the emergence of nanomaterials, different imaging modalities have been integrated into one single platform, and combined therapies with synergetic effects against gastric cancer were established. Moreover, the development of theragnostic strategies with simultaneous diagnostic and therapeutic ability was boosted by multifunctional nanoparticles. The present review discusses about the gastric cancer including its mortality rate, secular trends, pathophysiology, etiology, risk factors, diagnosis, and different treatment approaches with major emphasis on herbal bioactives (quercetin, paclitaxel, resveratrol, curcumin and ginsenosides) and different herbal constituent encapsulated nano-formulations (such as nanoparticles, niosomes, liposomes, nano-emulsion, and micelles). Challenges and future prospects of herbal bioactive encapsulated nano-formulations for the treatment/management of gastric cancers has been included in the later part of the manuscript.
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来源期刊
Nano Futures
Nano Futures Chemistry-General Chemistry
CiteScore
4.30
自引率
0.00%
发文量
35
期刊介绍: Nano Futures mission is to reflect the diverse and multidisciplinary field of nanoscience and nanotechnology that now brings together researchers from across physics, chemistry, biomedicine, materials science, engineering and industry.
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