静电纺纤维:控制释放应用的通用方法

IF 3.4 4区 化学 Q2 POLYMER SCIENCE International Journal of Polymer Science Pub Date : 2022-10-17 DOI:10.1155/2022/9116168
Sepideh Karimi Afshar, Mohammadmohsen Abdorashidi, F. Dorkoosh, H. Akbari Javar
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引用次数: 12

摘要

静电纺丝是上个世纪最有吸引力的纤维制造方法之一。已经进行了许多研究,特别是在组织工程和使用电纺纤维的药物递送方面。在这些纤维上或纤维内装载许多不同的药物和生物活性剂可增强这些系统的功效;然而,市场上仍然没有这种技术的商业产品。已经开发了各种方法来改善结构的机械和物理化学行为,从而在释放的时间、地点或数量方面实现更可控的递送系统。在本研究中,综述了制备控释电纺纤维的最常用方法。尽管在制备控释纤维方面取得了许多成就,但要达到适用于制药行业的合格、可重复的系统,仍有许多挑战需要解决。
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Electrospun Fibers: Versatile Approaches for Controlled Release Applications
Electrospinning has been one of the most attractive methods of fiber fabrication in the last century. A lot of studies have been conducted, especially in tissue engineering and drug delivery using electrospun fibers. Loading many different drugs and bioactive agents on or within these fibers potentiates the efficacy of such systems; however, there are still no commercial products with this technology available in the market. Various methods have been developed to improve the mechanical and physicochemical behavior of structures toward more controllable delivery systems in terms of time, place, or quantity of release. In this study, most frequent methods used for the fabrication of controlled release electrospun fibers have been reviewed. Although there are a lot of achievements in the fabrication of controlled release fibers, there are still many challenges to be solved to reach a qualified, reproducible system applicable in the pharmaceutical industry.
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来源期刊
CiteScore
6.10
自引率
0.00%
发文量
55
审稿时长
>12 weeks
期刊介绍: The International Journal of Polymer Science is a peer-reviewed, Open Access journal that publishes original research articles as well as review articles on the chemistry and physics of macromolecules.
期刊最新文献
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