基于HIV感染者白细胞总数的CD4+范围预测

J. O. Rodríguez Velásquez, E. Prieto, C. E. Pérez Díaz, C. A. Valdés Cadena, G. F. Bulla, F. A. Barrios Arroyave, N. López, F. López
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引用次数: 0

摘要

客观的根据概率论中的绝对白细胞计数,预测CD4 T淋巴细胞值高于500个细胞/μL3和/或介于200至500个细胞-μL3的患者记录序列中CD4+/μL3的数量。材料和方法。进行了两次数学归纳,以从白细胞的绝对计数中找到CD4+/μL3在500个细胞/μL3以上和200至500个细胞-μL3之间的预测数学关系。随后,计算预测成功的概率,对剩余的80个数据进行两次盲研究,并计算两种情况的敏感性和特异性。结果和讨论。如果每个患者在时间上有三个以上的记录,并且这些记录超过500个CD4/μL3细胞或在200到500个CD4/μL3之间,发现所有记录的绝对白细胞计数都大于或等于3并低于4,则将保持以下记录,CD4淋巴细胞的测量值>500或在[200500]之间,如果在患者序列的白细胞绝对计数中观察到值为4并且CD4+的范围为200至500个细胞/μ,可以推断,至少有一次CD4+/μL3的测量值大于500个细胞/μL3,而白细胞测量值/μL3大于3.7。
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Prediction of CD4+ ranges based on the total number of leukocytes in people living with HIV
Objective. To predict the amount of CD4+/μL3 in sequences of patient records with CD4 T lymphocyte values above 500 cells/μL3 and / or between 200 to 500 cells/μL3 from the absolute leukocyte count in the context of the theory of probability.Materials and methods. Two mathematical inductions were performed to find predictive mathematical relationships for CD4+/μL3 when they are above 500 cells/μL3 and between 200 to 500 cells/μL3, from the absolute count of leukocytes. Subsequently, the probability of success of the predictions was calculated, two blind studies were performed on 80 remaining data, and sensitivity and specificity were calculated for both cases.Results and discussion. If there are more than three records in time per patient, and these are above 500 CD4/μL3 cells or between 200 to 500 CD4/μL3 cells, finding that the absolute leukocyte count has a greater or equal value to three and lower to 4 for all the records, the following record will be maintained with a measurement of CD4 lymphocytes>500 or between [200, 500], if in the absolute count of leukocytes of the patient sequences a value of four is observed and CD4+ ranges from 200 to 500 cells/μL3, it can be deduced that there will be at least one measurement of CD4 +>500 cells/μL3 associated with a leukocyte measurement / μL3 greater than 3.7.Conclusions. We established two temporal mathematical patterns capable of predicting the CD4+/μL3 count from the absolute leukocyte count.
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来源期刊
HIV Infection and Immunosuppressive Disorders
HIV Infection and Immunosuppressive Disorders Medicine-Infectious Diseases
CiteScore
0.70
自引率
0.00%
发文量
37
期刊介绍: In the scientific-practical journal "HIV Infection and Immunosuppressive Disorders", published various issues of HIV medicine (epidemiology, molecular mechanisms of pathogenesis to the development of educational programs) leading scientists of Russia and countries of CIS, USA, as well as practical healthcare professionals working in research centers, research institutes, universities, clinics where done basic medical work. A special place on the pages of the publication is given to basic and clinical research, analytical reviews of contemporary and foreign reports, the provision of medical care for various diseases.
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