在花粉量高的日子里,情绪恶化与夏季季节性模式有关

IF 0.5 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Pteridines Pub Date : 2019-01-01 DOI:10.1515/pteridines-2019-0016
F. Akram, Tyler B. Jennings, J. Stiller, C. Lowry, T. Postolache
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引用次数: 5

摘要

摘要背景:夏春季型季节性情感障碍(S-SAD)是季节性情感疾病中不太常见的亚型,关于S-SAD潜在诱因的证据很少。最近的报告支持空气中的花粉与抑郁症的季节性恶化(情绪季节性)和自杀行为的时间有关。因此,我们假设具有夏春季季节性模式(简称夏季模式)和S-SAD的阿米什旧秩序(OOA)在花粉旺盛的日子里情绪会显著恶化。方法:采用季节性模式评估问卷(SPAQ)估计情绪恶化的季节性模式和SAD参数。进行了年龄和性别调整的ANCOVA和事后分析,以比较花粉计数高的日子里情绪恶化的夏季模式与无夏季模式情绪恶化、S-SAD与无-S-SAD、冬季模式与无冬季模式情绪恶化以及W-SAD与非-W-SAD组。结果:S-SAD的患病率为0.4%,而4.5%的人具有夏季情绪季节性模式。在夏季模式和无夏季模式的情绪恶化之间,观察到高花粉日情绪恶化的统计学显著差异(p=0.006)。S-SAD组与无SAD组之间的高花粉日心情恶化的显著关联(p=0.032)经不起Bonferroni的多重比较调整。情绪恶化的冬季模式与无冬季模式(p=0.61)以及W-SAD与无-W-SAD(p=0.19)组没有发现显著关联。结论:我们的研究结果与先前的研究一致,即空气过敏原暴露与夏季季节性模式之间存在联系,但与冬季季节性模式无关。
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Mood Worsening on Days with High Pollen Counts is associated with a Summer Pattern of Seasonality
Abstract Background: Summer/spring-type seasonal affective disorder (S-SAD) is the less common subtype of seasonal affective disorder and evidence regarding potential triggers of S-SAD is scarce. Recent reports support association of airborne-pollen with seasonal exacerbation of depression (mood seasonality) and timing of suicidal behavior. Therefore, we hypothesized that Old Order Amish (OOA) with summer/spring pattern of seasonality (abbreviated as summer pattern) and S-SAD will have significant mood worsening on high pollen days. Methods: A seasonal pattern of mood worsening and SAD parameters were estimated using Seasonal Pattern Assessment Questionnaire (SPAQ). Age- and gender-adjusted ANCOVAs and post hoc analyses were conducted to compare mood worsening on days with high pollen counts between summer-pattern vs no-summer-pattern of mood worsening, S-SAD vs no-S-SAD, winter-pattern vs no-winter-pattern of mood worsening, and W-SAD vs no-W-SAD groups. Results: The prevalence of S-SAD was 0.4%, while 4.5% of individuals had a summer pattern of mood seasonality. A statistically significant difference for mood worsening on high pollen days was observed between summer-pattern vs no-summer-pattern of mood worsening (p = 0.006). The significant association between S-SAD vs no-SAD groups (p = 0.032) for mood worsening on high pollen days did not withstand Bonferroni adjustment for multiple comparisons. No significant association was found for winter-pattern vs no-winter-pattern of mood worsening (p = 0.61) and for W-SAD vs no-W-SAD (p = 0.19) groups. Conclusion: Our results are consistent with previous studies implicating links between aeroallergen exposure and summer pattern of seasonality, but not the winter pattern of seasonality.
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来源期刊
Pteridines
Pteridines 生物-生化与分子生物学
CiteScore
1.20
自引率
25.00%
发文量
6
审稿时长
>12 weeks
期刊介绍: Pteridines is an open acess international quarterly journal dealing with all aspects of pteridine research. Pteridines are heterocyclic fused ring compounds involved in a wide range of biological functions from the color on butterfly wings to cofactors in enzyme catalysis to essential vitamins. Of the pteridines, 5,6,7,8-tetrahydrobiopterin is the necessary cofactor of several aromatic amino acid monoxygenases, the nitric oxide synthases and glyceryl ether monoxygenase (GEMO). Neopterin plays an essential role in the immune system and is an important biomarker in laboratory medicine for diseases such as HIV, cardiovascular disease, malignant tumors, among others. Topics: -Neopterin, dihydroneopterin, monapterin- Biopterin, tetrahydrobiopterin- Folates, antifolates, riboflavin- Phenylalanine, tyrosine, phenylketonuria, serotonin, adrenalin, noradrenalin, L-DOPA, dopamine, related biogenic amines- Phenylalanine hydroxylase, tyrosine hydroxylase, tryptophan hydroxylase, nitric oxide synthases (iNOS), alkylglycerol monooxygenase (AGMO), dihydropterin reductase, sepiapterin reductase- Homocysteine, mediators of inflammation, redox systems, iron.
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