{"title":"5-羟色胺受体4","authors":"R. Gurbanov, Hazel Karadağ","doi":"10.4267/2042/70748","DOIUrl":null,"url":null,"abstract":"Being a member of the serotonin receptor family, 5HT4 receptor ties up the neurotransmitter-serotonin (5-hydroxytryptamine/ 5-HT) in the central nervous system (CNS) of mammals. Commonly 5-HT4 receptors (5-HTR4) are G-protein-coupled receptors (GPCRs), in which the G proteins cause the induction of adenylate cyclase, subsequently leading to cyclic adenosine monophosphate (cAMP) and protein kinase A (PKA) activations. These receptors are commonly expressed in gastrointestinal, cardiovascular, nervous, and urinary systems, as well as the adrenal cortex (Tack et al., 2012). In this review article, the genetic, cellular, and biochemical knowledge of 5-HT4 receptors is deliberated. Besides the emphasis on receptor-ligand interaction with therapeutics, the implication of these receptors in several health disturbances/diseases is considered on the basis of available literature.","PeriodicalId":52212,"journal":{"name":"Atlas of Genetics and Cytogenetics in Oncology and Haematology","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"HTR4 (5-hydroxytryptamine receptor 4)\",\"authors\":\"R. Gurbanov, Hazel Karadağ\",\"doi\":\"10.4267/2042/70748\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Being a member of the serotonin receptor family, 5HT4 receptor ties up the neurotransmitter-serotonin (5-hydroxytryptamine/ 5-HT) in the central nervous system (CNS) of mammals. Commonly 5-HT4 receptors (5-HTR4) are G-protein-coupled receptors (GPCRs), in which the G proteins cause the induction of adenylate cyclase, subsequently leading to cyclic adenosine monophosphate (cAMP) and protein kinase A (PKA) activations. These receptors are commonly expressed in gastrointestinal, cardiovascular, nervous, and urinary systems, as well as the adrenal cortex (Tack et al., 2012). In this review article, the genetic, cellular, and biochemical knowledge of 5-HT4 receptors is deliberated. Besides the emphasis on receptor-ligand interaction with therapeutics, the implication of these receptors in several health disturbances/diseases is considered on the basis of available literature.\",\"PeriodicalId\":52212,\"journal\":{\"name\":\"Atlas of Genetics and Cytogenetics in Oncology and Haematology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Atlas of Genetics and Cytogenetics in Oncology and Haematology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4267/2042/70748\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Atlas of Genetics and Cytogenetics in Oncology and Haematology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4267/2042/70748","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
Being a member of the serotonin receptor family, 5HT4 receptor ties up the neurotransmitter-serotonin (5-hydroxytryptamine/ 5-HT) in the central nervous system (CNS) of mammals. Commonly 5-HT4 receptors (5-HTR4) are G-protein-coupled receptors (GPCRs), in which the G proteins cause the induction of adenylate cyclase, subsequently leading to cyclic adenosine monophosphate (cAMP) and protein kinase A (PKA) activations. These receptors are commonly expressed in gastrointestinal, cardiovascular, nervous, and urinary systems, as well as the adrenal cortex (Tack et al., 2012). In this review article, the genetic, cellular, and biochemical knowledge of 5-HT4 receptors is deliberated. Besides the emphasis on receptor-ligand interaction with therapeutics, the implication of these receptors in several health disturbances/diseases is considered on the basis of available literature.
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