细胞因子受体样因子2

Q4 Medicine Atlas of Genetics and Cytogenetics in Oncology and Haematology Pub Date : 2019-12-01 DOI:10.4267/2042/70641

D. Moreno-Lorenzana, R. Juárez-Velázquez, D. Martínez-Anaya, Patricia Péez-Vera

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引用次数: 3

摘要

CRLF2是I型细胞因子受体家族的成员。CRLF2与il - 7受体α链和胸腺基质淋巴生成素形成功能复合物，该复合物诱导信号转导和转录蛋白激活因子的激活。基因重排诱导的CRLF2过表达已在急性淋巴细胞白血病中被描述。

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CRLF2 (Cytokine receptor like factor 2)

CRLF2 is a member of type I cytokine receptor family. CRLF2 forms a functional complex with IL7 receptor α chain and thymic stromal lymphopoietin, this complex induces the activation of signal transducers and activators of transcription proteins. The overexpression of CRLF2 induced by genetic rearrangements has been described in acute lymphoblastic leukemia.

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Atlas of Genetics and Cytogenetics in Oncology and Haematology Medicine-Oncology

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