患者的抱怨-作为结核合并HIV感染不良结局的预测因素

V. S. Borovitsky
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引用次数: 0

摘要

目标。检测患者入院时的投诉,统计上具有重要的不良预后的结核合并HIV感染,最敏感和特异性。材料和方法。对363例患者进行结核病和HIV感染检查。第一组59例(16.3%)患者预后不良,第二组304例(86.7%)患者预后良好。方法:临床、实验室、微生物学、统计学:采用Pearson标准分析两两列联表,Mann-Whitney检验定量特征,logistic回归。结果和讨论。在艾滋病毒和结核病患者的主诉中,敏感性和特异性的最高比值比(极有可能发生不良后果的风险)(< 0.0001)有发热- 26,8,93,2%和66,1%,稀便- 25,4,40,7%和97,4%,体重减轻- 18,8,72,9%和87,5%,食欲不振- 17,0,69,5%和88,2%,呼吸急促- 15,6,79,7%和79,9%,虚弱- 8,7,91.5%和44,7%,头痛- 7,4,49,2%和88,5%。因此,在没有其他投诉的情况下,与没有此类投诉的患者相比,艾滋病毒和结核病患者的不良后果风险增加:发烧26,8倍,大便稀- 25,4次,体重减轻- 18,8次,食欲不振- 17,0次,呼吸短促- 15,6次,虚弱- 8,7次,头痛- 7,4次。
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Complaints of a patient — as predictors of adverse outcomes in tuberculosis with HIV infection
Objective. To detect patient’s complaints on admission to the hospital, statistically important with adverse outcome in tuberculosis with HIV infection, most sensitivity and specificity.Materials and methods. 363 patients were examined with tuberculosis and HIV infection. The first group included 59 (16,3%) patients with adverse disease outcome, the second group contained 304 patients (83,7%) with favorable outcome. Methods: clinical, laboratory, microbiological, statistical: analysis of pairwise contingency tables by Pearson’s criterion, Mann-Whitney test on quantitative characteristics, logistic regression.Results and discussion. The highest odds ratio of sensitivity and specificity among HIV and tuberculosis patient’s complaints, highly probable on risk of adverse outcome (р<0,0001), has fever — 26,8, 93,2% and 66,1%, loose stools — 25,4, 40,7% and 97,4%, weight loss — 18,8, 72,9% and 87,5%, loss of appetite — 17,0, 69,5% and 88,2%, shortness of breath — 15,6, 79,7% and 79,9%, weakness — 8,7, 91,5% and 44,7%, headache — 7,4, 49,2% and 88,5% accordingly. Thus, in the absence of other complaints the risk of adverse outcome in a patient with HIV and tuberculosis, compared to a patient with no such complaints increases for fever 26,8 times, for loose stools — 25,4 times, for weight loss — 18,8 times, for loss of appetite — 17,0 times, for shortness of breath —15,6 times, for weakness — 8,7 times, for headache — 7,4 times.
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来源期刊
HIV Infection and Immunosuppressive Disorders
HIV Infection and Immunosuppressive Disorders Medicine-Infectious Diseases
CiteScore
0.70
自引率
0.00%
发文量
37
期刊介绍: In the scientific-practical journal "HIV Infection and Immunosuppressive Disorders", published various issues of HIV medicine (epidemiology, molecular mechanisms of pathogenesis to the development of educational programs) leading scientists of Russia and countries of CIS, USA, as well as practical healthcare professionals working in research centers, research institutes, universities, clinics where done basic medical work. A special place on the pages of the publication is given to basic and clinical research, analytical reviews of contemporary and foreign reports, the provision of medical care for various diseases.
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