RNA测序鉴定2型糖尿病患者TPD52-Like3基因和NKX2-1基因的下调

Archives of diabetes & obesity Pub Date : 2020-11-12 DOI:10.32474/ado.2020.03.000156

R. Weijers

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引用次数: 2

摘要

在早期的一项研究中，有人提出遗传异常的最终结果导致2型糖尿病的发展，而2型糖尿病已经出现在糖尿病前期。与健康对照组相比，线粒体膜间空间的质子(H+离子)通过解偶联蛋白-1 (UCP1)重新进入基质，这被认为是由于通量增加而发生的。这会导致线粒体内部和周围的高热。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Identification of The Downregulation of TPD52-Like3 Gene and NKX2-1 Gene in Type 2 Diabetes Mellitus Via RNA Sequencing

In an earlier study, it was proposed that the final consequence of hereditary anomaly results in the development of type 2 diabetes, which already emerges in the prediabetic phase. It was thought to occur due to an increased flux, as compared to the healthy controls where protons (H+-ions) from the mitochondrial intermembranespace re-enter the matrix via uncoupling protein-1 (UCP1). This causes hyperthermia in and around the mitochondria [1].

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Archives of diabetes & obesity

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