L Aponte Becerra, B Galindo Mendez, F Khan, V Lioutas, P Novak, C S Mantzoros, L H Ngo, V Novak
Aims: To determine safety of intranasal insulin (INI) in MemAID trial participants with diabetes treated with systemic insulins.
Materials and methods: This randomized, double-blinded trial consisted of 24-week INI or placebo treatment once daily and 24-week follow-up. Safety outcomes were: 1) Short-term effects on glycemic variability, hypoglycemic episodes on continuous glucose monitoring (CGM) at baseline and on-treatment. 2) Long-term effects on glucose metabolism and weight on INI/placebo treatment and post-treatment follow-up. Of 86 screened subjects, 14 were randomized, 9 (5 INI, 4 Placebo) completed CGM at baseline and on-treatment, and 5 (2 INI, 3 Placebo) completed treatment and follow-up.
Results: INI was safe and was not associated with serious adverse events, hypoglycemic episodes or weight gain. INI administration did not acutely affect capillary glucose. Glycemic variability on CGM decreased with INI, compared to baseline. On INI treatment, there was a long-term trend toward lower HbA1c, plasma glucose and insulin. No interactions with subcutaneous insulins were observed.
Conclusions: INI is safe in older people with diabetes treated with systemic insulins, and it is not associated with adverse events, hypoglycemia or weight gain. Future studies are needed to determine whether INI administration can reduce glycemic variability, improve insulin sensitivity and thus potentially lessen diabetes burden in this population.
{"title":"Safety of Intranasal Insulin in Type 2 Diabetes on Systemic Insulin: A Double-Blinded Placebo-Controlled Sub-Study of Memaid Trial.","authors":"L Aponte Becerra, B Galindo Mendez, F Khan, V Lioutas, P Novak, C S Mantzoros, L H Ngo, V Novak","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Aims: </strong>To determine safety of intranasal insulin (INI) in MemAID trial participants with diabetes treated with systemic insulins.</p><p><strong>Materials and methods: </strong>This randomized, double-blinded trial consisted of 24-week INI or placebo treatment once daily and 24-week follow-up. Safety outcomes were: 1) Short-term effects on glycemic variability, hypoglycemic episodes on continuous glucose monitoring (CGM) at baseline and on-treatment. 2) Long-term effects on glucose metabolism and weight on INI/placebo treatment and post-treatment follow-up. Of 86 screened subjects, 14 were randomized, 9 (5 INI, 4 Placebo) completed CGM at baseline and on-treatment, and 5 (2 INI, 3 Placebo) completed treatment and follow-up.</p><p><strong>Results: </strong>INI was safe and was not associated with serious adverse events, hypoglycemic episodes or weight gain. INI administration did not acutely affect capillary glucose. Glycemic variability on CGM decreased with INI, compared to baseline. On INI treatment, there was a long-term trend toward lower HbA1c, plasma glucose and insulin. No interactions with subcutaneous insulins were observed.</p><p><strong>Conclusions: </strong>INI is safe in older people with diabetes treated with systemic insulins, and it is not associated with adverse events, hypoglycemia or weight gain. Future studies are needed to determine whether INI administration can reduce glycemic variability, improve insulin sensitivity and thus potentially lessen diabetes burden in this population.</p>","PeriodicalId":93731,"journal":{"name":"Archives of diabetes & obesity","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9328174/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40554652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-09DOI: 10.32474/ado.2021.03.000172
A. Avery
Aim/Hypothesis: This mixed-methods evaluation investigates the impact of Slimming World (SW) membership on weight, glycaemic control and mental-health related quality of life in adults with both T1D and T2D who either self-referred or were referred by a healthcare professional. It also evaluates the ease of application and the accessibility of the support offered to determine long-term sustainability of the lifestyle changes made. The hypothesis was that both glycaemic control and improvements in mental well-being are positively associated with weight loss and that participants would find the intervention easy to follow and achieve weight loss (≥10%). Methods:
{"title":"Can A Community-Based Weight Management Programme, that is Scalable, Provide Effective Diabetes Management Support for Adults with T1D or T2D: A Mixed Methods Evaluation","authors":"A. Avery","doi":"10.32474/ado.2021.03.000172","DOIUrl":"https://doi.org/10.32474/ado.2021.03.000172","url":null,"abstract":"Aim/Hypothesis: This mixed-methods evaluation investigates the impact of Slimming World (SW) membership on weight, glycaemic control and mental-health related quality of life in adults with both T1D and T2D who either self-referred or were referred by a healthcare professional. It also evaluates the ease of application and the accessibility of the support offered to determine long-term sustainability of the lifestyle changes made. The hypothesis was that both glycaemic control and improvements in mental well-being are positively associated with weight loss and that participants would find the intervention easy to follow and achieve weight loss (≥10%). Methods:","PeriodicalId":93731,"journal":{"name":"Archives of diabetes & obesity","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49275331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-17DOI: 10.32474/ado.2020.03.000158
E. Wat, Johnny Cm Koon, C. Lau, P. Chook, William Kf Cheng, P. Leung, Choly Tm Yan, Wai-Lun Kwong
As cardiovascular diseases have become dominant causes of mortality, other related pathological presentations are gaining...
随着心血管疾病成为死亡的主要原因，其他相关病理表现也在增加。
{"title":"An Evidence-Based Herbal Supplement for The Control of Metabolic Syndrome","authors":"E. Wat, Johnny Cm Koon, C. Lau, P. Chook, William Kf Cheng, P. Leung, Choly Tm Yan, Wai-Lun Kwong","doi":"10.32474/ado.2020.03.000158","DOIUrl":"https://doi.org/10.32474/ado.2020.03.000158","url":null,"abstract":"As cardiovascular diseases have become dominant causes of mortality, other related pathological presentations are gaining...","PeriodicalId":93731,"journal":{"name":"Archives of diabetes & obesity","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44800281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-13DOI: 10.32474/ado.2020.03.000157
Ó. Moreno-Pérez, C. Tejera, R. Reyes-Garcia
Clinical management of older diabetes people requires a comprehensive evaluation and a holistic approach for the...
老年糖尿病患者的临床管理需要一个全面的评估和整体的方法。。。
{"title":"Diabetes in Older People: Comprehensive Approach","authors":"Ó. Moreno-Pérez, C. Tejera, R. Reyes-Garcia","doi":"10.32474/ado.2020.03.000157","DOIUrl":"https://doi.org/10.32474/ado.2020.03.000157","url":null,"abstract":"Clinical management of older diabetes people requires\u0000a comprehensive evaluation and a holistic approach for the...","PeriodicalId":93731,"journal":{"name":"Archives of diabetes & obesity","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42610742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-12DOI: 10.32474/ado.2020.03.000156
R. Weijers
In an earlier study, it was proposed that the final consequence of hereditary anomaly results in the development of type 2 diabetes, which already emerges in the prediabetic phase. It was thought to occur due to an increased flux, as compared to the healthy controls where protons (H+-ions) from the mitochondrial intermembranespace re-enter the matrix via uncoupling protein-1 (UCP1). This causes hyperthermia in and around the mitochondria [1].
{"title":"Identification of The Downregulation of TPD52-Like3 Gene and NKX2-1 Gene in Type 2 Diabetes Mellitus Via RNA Sequencing","authors":"R. Weijers","doi":"10.32474/ado.2020.03.000156","DOIUrl":"https://doi.org/10.32474/ado.2020.03.000156","url":null,"abstract":"In an earlier study, it was proposed that the final consequence of hereditary anomaly results in the development of type 2 diabetes, which already emerges in the prediabetic phase. It was thought to occur due to an increased flux, as compared to the healthy controls where protons (H+-ions) from the mitochondrial intermembranespace re-enter the matrix via uncoupling protein-1 (UCP1). This causes hyperthermia in and around the mitochondria [1].","PeriodicalId":93731,"journal":{"name":"Archives of diabetes & obesity","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46417396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-05DOI: 10.32474/ado.2020.03.000155
L. Rochette, A. Méloux, E. Rigal, M. Zeller, Y. Cottin, C. Vergely
Mitochondria play a critical role in maintaining cellular function by ATP production. In addition to its role in energy production...
线粒体通过ATP的产生在维持细胞功能中起关键作用。除了在能源生产中的作用外……
{"title":"Properties of Mitochondrial-Derived Peptides (Mdps), Type 2 Diabetes, and Relationship with Oxidative Stress","authors":"L. Rochette, A. Méloux, E. Rigal, M. Zeller, Y. Cottin, C. Vergely","doi":"10.32474/ado.2020.03.000155","DOIUrl":"https://doi.org/10.32474/ado.2020.03.000155","url":null,"abstract":"Mitochondria play a critical role in maintaining cellular function\u0000by ATP production. In addition to its role in energy production...","PeriodicalId":93731,"journal":{"name":"Archives of diabetes & obesity","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42638578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-10-27DOI: 10.32474/ado.2020.03.000154
Joséphine Gehring, D. Azzout-Marniche, P. Even
Fibroblast growth factor 21 (FGF21) is a hepatokine member of a subfamily of “fibroblast growth factors” that responds to multiple...
成纤维细胞生长因子21 (FGF21)是“成纤维细胞生长因子”亚家族的一种肝因子成员，对多种…
{"title":"Variability in Plasma FGF21 Levels in Rats Fed A Standard 15% Protein Diet is not Sensitive Enough to Reflect Differences in Protein Requirements","authors":"Joséphine Gehring, D. Azzout-Marniche, P. Even","doi":"10.32474/ado.2020.03.000154","DOIUrl":"https://doi.org/10.32474/ado.2020.03.000154","url":null,"abstract":"Fibroblast growth factor 21 (FGF21) is a hepatokine member of\u0000a subfamily of “fibroblast growth factors” that responds to multiple...","PeriodicalId":93731,"journal":{"name":"Archives of diabetes & obesity","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42604252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-09-28DOI: 10.32474/ado.2020.03.000152
Gundu H. R. Rao
SARS-CoV-2 virus has created an unprecedented public health and global economic crisis. Despite the fact...
严重急性呼吸系统综合征冠状病毒2型造成了前所未有的公共卫生和全球经济危机。尽管事实。。。
{"title":"Excess Weight, Obesity, Diabetes and Coronavirus Disease","authors":"Gundu H. R. Rao","doi":"10.32474/ado.2020.03.000152","DOIUrl":"https://doi.org/10.32474/ado.2020.03.000152","url":null,"abstract":"SARS-CoV-2 virus has created an unprecedented public health and global economic crisis. Despite the fact...","PeriodicalId":93731,"journal":{"name":"Archives of diabetes & obesity","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42744528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-09-25DOI: 10.32474/ADO.2020.02.000151
K. Bhuyan
The analytical results presented here were based on data collected from 960 adults of ages 18 years and above residing in both urban and rural areas of Bangladesh. The data were collected by some doctors and nurses from and nearby their working places according to quota sampling plan. The objective of the study was to investigate the impacts of different socioeconomic variables on simultaneous sufferings of adults from diabetes and high blood pressure and to identify the most responsible variables for this suffering. The analysis indicated that 5.4 percent adults were simultaneously suffering from both diabetes and elevated blood pressure. The most responsible variable for the diseases was occupation followed by gender variation, income and expenditure. The results of risk ratio and factor analysis indicated that the females and physically inactive adults had the more chance of affecting by the disease. Males, non- user of can food and skilled or unskilled working group had less chance of affected by the disease. The variables were identified by factor analysis.
{"title":"Factors Responsible for Diabetes Elevated Blood Pressure Among Bangladeshi Adults","authors":"K. Bhuyan","doi":"10.32474/ADO.2020.02.000151","DOIUrl":"https://doi.org/10.32474/ADO.2020.02.000151","url":null,"abstract":"The analytical results presented here were based on data collected from 960 adults of ages 18 years and above residing in both urban and rural areas of Bangladesh. The data were collected by some doctors and nurses from and nearby their working places according to quota sampling plan. The objective of the study was to investigate the impacts of different socioeconomic variables on simultaneous sufferings of adults from diabetes and high blood pressure and to identify the most responsible variables for this suffering. The analysis indicated that 5.4 percent adults were simultaneously suffering from both diabetes and elevated blood pressure. The most responsible variable for the diseases was occupation followed by gender variation, income and expenditure. The results of risk ratio and factor analysis indicated that the females and physically inactive adults had the more chance of affecting by the disease. Males, non- user of can food and skilled or unskilled working group had less chance of affected by the disease. The variables were identified by factor analysis.","PeriodicalId":93731,"journal":{"name":"Archives of diabetes & obesity","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42882826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-09-02DOI: 10.32474/ADO.2020.02.000150
Ahed J. Alkhatib
Diabetes type 2 represents a global health problem, and it is expected to influence approximately 530 million people by 2030. Usually, diabetes type 2 is developed through more than one stage. Prediabetes is a preliminary stage of diabetes before developing full episodes of diabetes.Diabetes type 2 can be preventable following appropriate lifestyles. The main objective of this study is to describe a case with liver cirrhosis and the patient was recommended for liver transplantation. Following reviewing of his profile, it was apparent that the patient had prediabetes (glucose level was 126mg/dl). The patient was recommended to use tadalafil 5 mg daily to offer improvement of liver function based on previous experience. Glucose level was daily measured. It was interestingly found that glucose levels were restored to normal levels between 85-100 mg/dl. Taken together, prediabetes can be treated using non-classical therapeutic approaches and full events can be prevented accordingly.
{"title":"Prediabetes can be Reversed Using Low Dose Tadalafil: Non- Classical Treatment of Diabetes as A New Medical Hypothesis","authors":"Ahed J. Alkhatib","doi":"10.32474/ADO.2020.02.000150","DOIUrl":"https://doi.org/10.32474/ADO.2020.02.000150","url":null,"abstract":"Diabetes type 2 represents a global health problem, and it is expected to influence approximately 530 million people by 2030. Usually, diabetes type 2 is developed through more than one stage. Prediabetes is a preliminary stage of diabetes before developing full episodes of diabetes.Diabetes type 2 can be preventable following appropriate lifestyles. The main objective of this study is to describe a case with liver cirrhosis and the patient was recommended for liver transplantation. Following reviewing of his profile, it was apparent that the patient had prediabetes (glucose level was 126mg/dl). The patient was recommended to use tadalafil 5 mg daily to offer improvement of liver function based on previous experience. Glucose level was daily measured. It was interestingly found that glucose levels were restored to normal levels between 85-100 mg/dl. Taken together, prediabetes can be treated using non-classical therapeutic approaches and full events can be prevented accordingly.","PeriodicalId":93731,"journal":{"name":"Archives of diabetes & obesity","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49316837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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