Lucija Hok, Davorin Šakić, Valerije Vrček, Robert Vianello
{"title":"立体异构化过程的药学意义","authors":"Lucija Hok, Davorin Šakić, Valerije Vrček, Robert Vianello","doi":"10.15255/kui.2022.027","DOIUrl":null,"url":null,"abstract":"Investigation of the stereoisomerisation process is of the utmost importance in pharmaceutical chemistry and biomedicine. Different isomers can exhibit significant differences when interacting with biological macromolecules, which may result in their modified pharmacokinetic and phar - macodynamic properties, thereby showing different therapeutic and undesirable effects. Although there are numerous examples illustrating the importance of stereochemistry, this article presents an overview of the most significant and representative cases in pharmacy.","PeriodicalId":43849,"journal":{"name":"Kemija u Industriji-Journal of Chemists and Chemical Engineers","volume":" ","pages":""},"PeriodicalIF":0.6000,"publicationDate":"2023-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Farmaceutski značaj procesa stereoizomerizacije\",\"authors\":\"Lucija Hok, Davorin Šakić, Valerije Vrček, Robert Vianello\",\"doi\":\"10.15255/kui.2022.027\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Investigation of the stereoisomerisation process is of the utmost importance in pharmaceutical chemistry and biomedicine. Different isomers can exhibit significant differences when interacting with biological macromolecules, which may result in their modified pharmacokinetic and phar - macodynamic properties, thereby showing different therapeutic and undesirable effects. Although there are numerous examples illustrating the importance of stereochemistry, this article presents an overview of the most significant and representative cases in pharmacy.\",\"PeriodicalId\":43849,\"journal\":{\"name\":\"Kemija u Industriji-Journal of Chemists and Chemical Engineers\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.6000,\"publicationDate\":\"2023-01-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Kemija u Industriji-Journal of Chemists and Chemical Engineers\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.15255/kui.2022.027\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Kemija u Industriji-Journal of Chemists and Chemical Engineers","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.15255/kui.2022.027","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Investigation of the stereoisomerisation process is of the utmost importance in pharmaceutical chemistry and biomedicine. Different isomers can exhibit significant differences when interacting with biological macromolecules, which may result in their modified pharmacokinetic and phar - macodynamic properties, thereby showing different therapeutic and undesirable effects. Although there are numerous examples illustrating the importance of stereochemistry, this article presents an overview of the most significant and representative cases in pharmacy.
期刊介绍：
Kemija u industriji (Chemistry in industry) is monthly journal which is being published already for almost 60 years continually and from very beginning it is a journal of chemists and chemical engineers. It is official journal of Croatian Society of Chemists and Engineers and of Croatian Chemical Society. It is edited by Croatian Society of Chemists and Engineers.
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