Samreen Pervez, M. Saeed, H. Khan, M. Shahid, I. Ullah
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Nephroprotective effect of Berberis baluchistanica against gentamicin-induced nephrotoxicity in rabbit
The present study was conducted to explore the protective effect of B. baluchistanica against gentamicin-induced renal toxicity in rabbits. Phytochemical investigations lead to the isolation of berberine and palmatine. The crude hydro-methanolic extract at various doses (100, 200 and 300 mg/kg body weight) elicited strong nephroprotective effects by restoring various biomarkers which were deranged by gentamicin such as creatinine, urea, serum uric acid levels (p<0.001) in plasma and urine output creatinine clearance, urinary protein and γ-glutamyl transferase level (p<0.001) in urine in a dose dependent manner. The mediators involved in oxidative stress such malondialdehyde, reduced glutathione, glutathione peroxidase, and catalase levels were significantly (P˂0.05-0.001) modulated in kidney tissue homogenate. Correspondingly, there is a significant (P<0.05) recovery in kidney weight and % loss in body weight compare to GM group. From these results, it is possible that B. baluchistanica exhibited protective effect mediated through the presence of berberine and palmatine.Video Clip of Methodology:Histopathology: 7 min 24 sec Full Screen Alternate
期刊介绍：
Bangladesh Journal of Pharmacology (Bangladesh J Pharmacol) is an open access, video component, peer-reviewed journal of the Bangladesh Pharmacological Society (BDPS).
A scholarly publication is defined ''open access'' when there are no financial, legal or technical barriers to accessing it. Anyone can read, download, copy, distribute, print or use it in educational purpose within the legal agreements.
Peer review of a manuscript means the evaluation of research work by one or more people with similar competences. It can be open or blind. We do the single-blind peer review.
Our readers want to know the methodology used by the researchers which is very important to get the results. The video clip of one of the methodologies is prepared by the authors and submit it to publish.
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