Bacterial spectrum and drug sensitivity analysis in necrotizing pancreatitis with extra-pancreatic infection

Objective To survey the bacterial spectrum and drug sensitivity in patients with necrotizing pancreatitis (NP) complicating with extra-pancreatic infection(EPI). Methods The clinical data of 79 NP with EPI patients from Jan 1, 2016 to Dec 31, 2018 were retrospectively analyzed. The strain identification and drug sensitivity test of positive specimens were statistically analyzed. Results A total of 219 strains of pathogenic bacteria were isolated, including 106(48.4%) gram-negative bacteria, 69(31.5%) gram-positive bacteria and 44(20.1%) fungi. The common pathogenic bacteria were Pseudomonas aeruginosa (10.1%), Staphylococcus epidermidis (9.1%) and Acinetobacter baumannii (9.1%). The resistance of common extrapancreatic pathogenic bacteria to penicillin and first and second generation cephalosporins was common. Conclusions The pathogenic bacteria of NP complicated with EPI were mainly Gram-negative bacteria, and the common sites of extra-pancreatic infection were bacteremia and respiratory tract. The third, fourth generation cephalosporins or carbapenems can be used empirically. Key words: Pancreatitis, acute necrotizing; Infection; Pathogenic bacteria; Drug sensitivity test