Pub Date : 2020-03-25DOI: 10.3760/CMA.J.CN113855-20191218-00751
Wei Xiaolong, Han Tonglei, Yudong Sun, Wu Yani, Zhu Jiang, W. Shiying, Dihao Wen, Zhiqing Zhao
Objective To investigate the outcomes of surgical treatment for carotid body tumor(CBT) without preoperative embolization at our institution. Methods 101 patients undergoing surgical treatment for CBT without preoperative embolization from 2011 to 2016 were followed-up for 2 years. Results Complete resection of the CBT was achieved in all 101 cases(100%). Post-operative adverse events(AEs) mostly observed during hospitalization were as tongue bias(Ⅰ: 4, 36.4%; Ⅱ: 8, 19.5%; Ⅲ: 13, 26.5%), hoarseness(Ⅰ: 1, 9.1%; Ⅱ: 4, 9.8%; Ⅲ: 7, 14.3%), dysphagia (Ⅰ: 0; Ⅱ: 2, 4.9%; Ⅲ: 7, 14.3%) and local hematoma(Ⅰ: 0; Ⅱ: 0; Ⅲ: 1, 2.0%). No other serious AEs were observed. The total incidence of AEs was 5(45.5%) in type Ⅰ patients, 14(34.1%) in type Ⅱ, and 28(57.1%) in type Ⅲ. At the end of 2 years of follow-up, there was no AEs in type Ⅰ patients. The number of patients with adverse events in type Ⅲ was greater than that in type Ⅱ (P>0.05). Three most frequently injured cranial nerves were hypoglossal nerve(21.9%), vagus nerve(20.3%), and recurrent laryngeal nerve(18.8%). Conclusion Surgical management without preoperative embolization for CBT patients does not increase the risk of complications nor is it related to prognosis. Key words: Carotid body tumor; Embolization; Postoperative complications
{"title":"Outcomes of surgical treatment for carotid body tumor without preoperative embolization: a single-center retrospective study","authors":"Wei Xiaolong, Han Tonglei, Yudong Sun, Wu Yani, Zhu Jiang, W. Shiying, Dihao Wen, Zhiqing Zhao","doi":"10.3760/CMA.J.CN113855-20191218-00751","DOIUrl":"https://doi.org/10.3760/CMA.J.CN113855-20191218-00751","url":null,"abstract":"Objective \u0000To investigate the outcomes of surgical treatment for carotid body tumor(CBT) without preoperative embolization at our institution. \u0000 \u0000 \u0000Methods \u0000101 patients undergoing surgical treatment for CBT without preoperative embolization from 2011 to 2016 were followed-up for 2 years. \u0000 \u0000 \u0000Results \u0000Complete resection of the CBT was achieved in all 101 cases(100%). Post-operative adverse events(AEs) mostly observed during hospitalization were as tongue bias(Ⅰ: 4, 36.4%; Ⅱ: 8, 19.5%; Ⅲ: 13, 26.5%), hoarseness(Ⅰ: 1, 9.1%; Ⅱ: 4, 9.8%; Ⅲ: 7, 14.3%), dysphagia (Ⅰ: 0; Ⅱ: 2, 4.9%; Ⅲ: 7, 14.3%) and local hematoma(Ⅰ: 0; Ⅱ: 0; Ⅲ: 1, 2.0%). No other serious AEs were observed. The total incidence of AEs was 5(45.5%) in type Ⅰ patients, 14(34.1%) in type Ⅱ, and 28(57.1%) in type Ⅲ. At the end of 2 years of follow-up, there was no AEs in type Ⅰ patients. The number of patients with adverse events in type Ⅲ was greater than that in type Ⅱ (P>0.05). Three most frequently injured cranial nerves were hypoglossal nerve(21.9%), vagus nerve(20.3%), and recurrent laryngeal nerve(18.8%). \u0000 \u0000 \u0000Conclusion \u0000Surgical management without preoperative embolization for CBT patients does not increase the risk of complications nor is it related to prognosis. \u0000 \u0000 \u0000Key words: \u0000Carotid body tumor; Embolization; Postoperative complications","PeriodicalId":66425,"journal":{"name":"中华普通外科杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43373908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-25DOI: 10.3760/CMA.J.CN113855-20190711-00381
Hui-min You, Yan Ding, Yanlan Zhou
Objective To explore the relationship of serum exosomal miRNA-21 expression and clinical pathological parameters and prognosis in gastric cancer (GC) patients. Methods Exosomes from serum samples of 52 GC patients and 10 healthy controls were extracted using the ExoQuick Exosome Precipitation Solution, and were further validated by immunoblotting for exosome markers and characterization of nanoparticle using NanoSight. The expression levels of exosomal miRNA-21 in exosomes was detected by RT-qPCR, and its relationship with clinicopathological features and prognosis was further analyzed. Results The expression level of miRNA-21 in serum exosomes of patients with GC was significantly higher than that of normal subjects (2.59±0.12 vs. 1.16±0.10, t=5.168, P<0.05), and its high expression was significantly related to tumor grade, depth of invasion, lymph node metastasis, distant metastasis, vascular invasion, nerve invasion and TNM stage (all P<0.05). Patients in exosomal miRNA-21 high expression group had lower overall survival than that of exosomal miRNA-21 low expression group (χ2=14.573, P<0.05). Multivariate analysis using the COX regression test identified that higher serum exosomal miRNA-21 was an independent predictor of mortality for GC patients (HR=2.863, 95%CI: 1.063-7.712, P=0.038). Conclusion The expression of miRNA-21 in serum exosomes of GC patients is up-regulated, and its high expression is associated with multiple unfavorable clinicopathological factors and poor prognosis of patients. Key words: Stomach neoplasms; Exosomes; MicroRNAs; Pathology , clinical; Prognosis
{"title":"Expression of serum exosomal miRNA-21 and its clinical significance in gastric cancer","authors":"Hui-min You, Yan Ding, Yanlan Zhou","doi":"10.3760/CMA.J.CN113855-20190711-00381","DOIUrl":"https://doi.org/10.3760/CMA.J.CN113855-20190711-00381","url":null,"abstract":"Objective \u0000To explore the relationship of serum exosomal miRNA-21 expression and clinical pathological parameters and prognosis in gastric cancer (GC) patients. \u0000 \u0000 \u0000Methods \u0000Exosomes from serum samples of 52 GC patients and 10 healthy controls were extracted using the ExoQuick Exosome Precipitation Solution, and were further validated by immunoblotting for exosome markers and characterization of nanoparticle using NanoSight. The expression levels of exosomal miRNA-21 in exosomes was detected by RT-qPCR, and its relationship with clinicopathological features and prognosis was further analyzed. \u0000 \u0000 \u0000Results \u0000The expression level of miRNA-21 in serum exosomes of patients with GC was significantly higher than that of normal subjects (2.59±0.12 vs. 1.16±0.10, t=5.168, P<0.05), and its high expression was significantly related to tumor grade, depth of invasion, lymph node metastasis, distant metastasis, vascular invasion, nerve invasion and TNM stage (all P<0.05). Patients in exosomal miRNA-21 high expression group had lower overall survival than that of exosomal miRNA-21 low expression group (χ2=14.573, P<0.05). Multivariate analysis using the COX regression test identified that higher serum exosomal miRNA-21 was an independent predictor of mortality for GC patients (HR=2.863, 95%CI: 1.063-7.712, P=0.038). \u0000 \u0000 \u0000Conclusion \u0000The expression of miRNA-21 in serum exosomes of GC patients is up-regulated, and its high expression is associated with multiple unfavorable clinicopathological factors and poor prognosis of patients. \u0000 \u0000 \u0000Key words: \u0000Stomach neoplasms; Exosomes; MicroRNAs; Pathology , clinical; Prognosis","PeriodicalId":66425,"journal":{"name":"中华普通外科杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48228748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-25DOI: 10.3760/CMA.J.CN113855-20200120-00041
Y. Miao, Y. Diao, Zuo-Guan Chen, Yuexin Chen, X. Tian, Ci-bo Huang, Jing Li, Yongjun Li
Objective To analyze the relevant risk factors for restenosis after percutaneous transluminal angioplasty of patients with Takayasu′s arteritis. Methods Clinical data of 43 patients undergoing percutaneous angioplasty due to Takayasu arteritis were retrospectively analyzed. Univariate and multivariate Logistic regression analysis was used to explore the relevant risk factors for restenosis after percutaneous transluminal angioplasty. Results There were 9 males and 34 females. The mean age was 23 (18-33) years old, 59 times of PTA were performed, including 44 in renal artery, 9 in aorta, 2 in iliac and 2 in carotid artery, 1 in brachiocephalic trunk and 1 in left subclavian artery. The mean follow up time was (64±42) months. The rate of restenosis was 47.5%(28/59)and the mean time of restenosis was (23±27) months. The restenosis rate of aorta and iliac artery was 9.1%, that of renal artery was 52.3% and that of supra aortic artery was 100% . The rate of restenosis was higher in patients with symptoms of headache, syncope and low back pain, the elevated ESR and CRP increased the risk of restenosis (all P<0.05). Multivariate Logistic analysis showed that preoperative elevation of ESR and CRP were risk factors for restenosis after percutaneous angioplasty for Takayasu arteritis. Conclusions PTA was safe and effective in Takayasu arteritis involving aorta-iliac and renal artery, the elevated ESR and CRP was related to high risk of restenosis. Key words: Takayasu arteritis; Angioplasty; Endovascular therapy
{"title":"Risk factors of restenosis of percutaneous transluminal angioplasty of Takayasu arteritis","authors":"Y. Miao, Y. Diao, Zuo-Guan Chen, Yuexin Chen, X. Tian, Ci-bo Huang, Jing Li, Yongjun Li","doi":"10.3760/CMA.J.CN113855-20200120-00041","DOIUrl":"https://doi.org/10.3760/CMA.J.CN113855-20200120-00041","url":null,"abstract":"Objective \u0000To analyze the relevant risk factors for restenosis after percutaneous transluminal angioplasty of patients with Takayasu′s arteritis. \u0000 \u0000 \u0000Methods \u0000Clinical data of 43 patients undergoing percutaneous angioplasty due to Takayasu arteritis were retrospectively analyzed. Univariate and multivariate Logistic regression analysis was used to explore the relevant risk factors for restenosis after percutaneous transluminal angioplasty. \u0000 \u0000 \u0000Results \u0000There were 9 males and 34 females. The mean age was 23 (18-33) years old, 59 times of PTA were performed, including 44 in renal artery, 9 in aorta, 2 in iliac and 2 in carotid artery, 1 in brachiocephalic trunk and 1 in left subclavian artery. The mean follow up time was (64±42) months. The rate of restenosis was 47.5%(28/59)and the mean time of restenosis was (23±27) months. The restenosis rate of aorta and iliac artery was 9.1%, that of renal artery was 52.3% and that of supra aortic artery was 100% . The rate of restenosis was higher in patients with symptoms of headache, syncope and low back pain, the elevated ESR and CRP increased the risk of restenosis (all P<0.05). Multivariate Logistic analysis showed that preoperative elevation of ESR and CRP were risk factors for restenosis after percutaneous angioplasty for Takayasu arteritis. \u0000 \u0000 \u0000Conclusions \u0000PTA was safe and effective in Takayasu arteritis involving aorta-iliac and renal artery, the elevated ESR and CRP was related to high risk of restenosis. \u0000 \u0000 \u0000Key words: \u0000Takayasu arteritis; Angioplasty; Endovascular therapy","PeriodicalId":66425,"journal":{"name":"中华普通外科杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44551885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-25DOI: 10.3760/CMA.J.CN113855-20191223-00762
Jinsong Wang, Yonghui Li, C. Yao, G. Chang, Zuojun Hu, Zi-lun Li, Mian Wang, Shenming Wang
Objective To investigate risk factors of nerve injury after carotid body tumor resection. Methods From 1991 to 2016, the clinical data of patients with neurologic complications after resection of carotid body tumor was retrospectively analyzed. Logistic regression analysis was used to investigate the risk factors of nerve injury. Results A total of 132 patients with 142 tumors underwent surgery. 45 patients (46 sides) suffered nerve injury, including 4 strokes and 44 nerve injuries. After active rehabilitation, 18 cases were left with permanent nerve injury, and the 4 patients with strokes regained self-care ability. By multivariate regression analysis, high-lying tumors (OR=4.345, P=0.005), Shamblin Ⅲ tumor (OR=4.382, P=0.047) increase the risks of postoperative nerve injury. Resection of high-lying tumors carried a higher risk of developing permanent nerve injury (OR=7.290, P=0.001). Conclusions Neurologic complication could be alleviated by rehabilitation. Intraoperative abrupt rupture of carotid artery is the leading cause of stroke. Shamblin Ⅲ and high-lying tumor are the predictors of postoperative nerve injury. Key words: Carotid body tumor; Postoperative complications; Nerve injury; Risk factors
{"title":"Risk factors of neurologic complications after surgical resection of carotid body tumor","authors":"Jinsong Wang, Yonghui Li, C. Yao, G. Chang, Zuojun Hu, Zi-lun Li, Mian Wang, Shenming Wang","doi":"10.3760/CMA.J.CN113855-20191223-00762","DOIUrl":"https://doi.org/10.3760/CMA.J.CN113855-20191223-00762","url":null,"abstract":"Objective \u0000To investigate risk factors of nerve injury after carotid body tumor resection. \u0000 \u0000 \u0000Methods \u0000From 1991 to 2016, the clinical data of patients with neurologic complications after resection of carotid body tumor was retrospectively analyzed. Logistic regression analysis was used to investigate the risk factors of nerve injury. \u0000 \u0000 \u0000Results \u0000A total of 132 patients with 142 tumors underwent surgery. 45 patients (46 sides) suffered nerve injury, including 4 strokes and 44 nerve injuries. After active rehabilitation, 18 cases were left with permanent nerve injury, and the 4 patients with strokes regained self-care ability. By multivariate regression analysis, high-lying tumors (OR=4.345, P=0.005), Shamblin Ⅲ tumor (OR=4.382, P=0.047) increase the risks of postoperative nerve injury. Resection of high-lying tumors carried a higher risk of developing permanent nerve injury (OR=7.290, P=0.001). \u0000 \u0000 \u0000Conclusions \u0000Neurologic complication could be alleviated by rehabilitation. Intraoperative abrupt rupture of carotid artery is the leading cause of stroke. Shamblin Ⅲ and high-lying tumor are the predictors of postoperative nerve injury. \u0000 \u0000 \u0000Key words: \u0000Carotid body tumor; Postoperative complications; Nerve injury; Risk factors","PeriodicalId":66425,"journal":{"name":"中华普通外科杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42037503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-25DOI: 10.3760/CMA.J.CN113855-20190715-00389
Na Li, Xiancong Huang, Zhongjian Chen, Yun Gao, W. Mao
Objective To evaluate preoperative serum ferritin (SF) in predicting the prognosis of patients with esophageal squamous cell carcinoma (ESCC). Methods A retrospective analysis was conducted on 280 ESCC patients undergoing radical resection of esophageal cancer at Zhejiang Cancer Hospital from Jan 2008 to Dec 2013. Univariate and multivariate analysis were used to investigate the relationship between preoperative SF level and patients′ clinicopathologic characteristics. Kaplain-Meier method was used to analyze the relationship between preoperative SF level and the prognosis. Results There were 183 cases (65.4%) with low SF level and 97cases (34.6%) with high SF level. The 1-, 3-and 5-year survival rates in low SF patients were 78.7%, 50.3%, 43.2% and that in high SF were 69.1%, 35.1%, 32.0%, respectively (χ2=4.697, P=0.031). Univariate analysis demonstrated that intravascular cancer embolus, nerve infiltration and the level of preoperative SF were related to ESCC patients prognosis (all P<0.05). The multivariate analysis showed that carcinoma cell embolus (OR=1.662, 95% CI: 1.239-2.229, P=0.001), nerve infiltration (OR=1.823, 95%CI: 1.361-2.443, P<0.001) and the level of preoperative SF (OR=1.504, 95%CI: 1.113-2.032, P=0.008) were independent risk factors for ESCC patients prognosis. Conclusion Preoperative SF level closely associates with the prognosis of ESCC patients. Key words: Esophageal neoplasms; Ferritins; Prognosis
{"title":"Prognostic value of preoperative serum ferritin in patients with esophageal squamous cell carcinoma","authors":"Na Li, Xiancong Huang, Zhongjian Chen, Yun Gao, W. Mao","doi":"10.3760/CMA.J.CN113855-20190715-00389","DOIUrl":"https://doi.org/10.3760/CMA.J.CN113855-20190715-00389","url":null,"abstract":"Objective \u0000To evaluate preoperative serum ferritin (SF) in predicting the prognosis of patients with esophageal squamous cell carcinoma (ESCC). \u0000 \u0000 \u0000Methods \u0000A retrospective analysis was conducted on 280 ESCC patients undergoing radical resection of esophageal cancer at Zhejiang Cancer Hospital from Jan 2008 to Dec 2013. Univariate and multivariate analysis were used to investigate the relationship between preoperative SF level and patients′ clinicopathologic characteristics. Kaplain-Meier method was used to analyze the relationship between preoperative SF level and the prognosis. \u0000 \u0000 \u0000Results \u0000There were 183 cases (65.4%) with low SF level and 97cases (34.6%) with high SF level. The 1-, 3-and 5-year survival rates in low SF patients were 78.7%, 50.3%, 43.2% and that in high SF were 69.1%, 35.1%, 32.0%, respectively (χ2=4.697, P=0.031). Univariate analysis demonstrated that intravascular cancer embolus, nerve infiltration and the level of preoperative SF were related to ESCC patients prognosis (all P<0.05). The multivariate analysis showed that carcinoma cell embolus (OR=1.662, 95% CI: 1.239-2.229, P=0.001), nerve infiltration (OR=1.823, 95%CI: 1.361-2.443, P<0.001) and the level of preoperative SF (OR=1.504, 95%CI: 1.113-2.032, P=0.008) were independent risk factors for ESCC patients prognosis. \u0000 \u0000 \u0000Conclusion \u0000Preoperative SF level closely associates with the prognosis of ESCC patients. \u0000 \u0000 \u0000Key words: \u0000Esophageal neoplasms; Ferritins; Prognosis","PeriodicalId":66425,"journal":{"name":"中华普通外科杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41578503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-25DOI: 10.3760/CMA.J.CN113855-20190520-00269
T. He, Jie Wu, Changsheng Xu, Pian-Pian Chen, Fanggang Cai
Objective To observe the effect of exogenous hydrogen sulfide(H2S) on the proliferation of rabbit vascular smooth muscle cell(VSMC) under high static pressure. Methods Rabbit thoracic aorta VSMC were isolated and cultured under high static pressure(100mmHg) and divided into control group [cultured with 0.2%fetal bovine serum(FBS) and no NaHS]、10%FBS group(10%FBS and no NaHS) and NaHS group(10%FBS and 50mmol/L NaHS). VSMC proliferation was analyzed with BUDR. CSE, Calmodulin(p-CaM)and CyclinD1 protein levels of VSMC were measured by Western blotting. Results Compared with the 10%FBS group, NaHS inhibit the proliferation of rabbit VSMC significantly (0.50±0.03 vs. 0.26±0.03, P<0.05). Compared with control group, CSE protein in the 10%FBS group decreased significantly(1.21±0.10 vs. 0.33±0.04, P<0.05) and p-CaM and CyclinD1 protein increased significantly(0.23±0.04 vs. 0.86±0.04 and 0.22±0.03 vs. 1.19±0.06, P<0.05). Compared with the 10%FBS group, CSE protein in NaHS group increased significantly(0.33±0.04 vs. 1.11±0.11, P<0.05), and the expression of p-CaM and CyclinD1 protein decreased significantly(0.86±0.04 vs. 0.26±0.05 and 1.19±0.06 vs. 0.51±0.03, P<0.05). Conclusion Exogenous hydrogen sulfide inhibits the proliferation of VSMC under high static pressure by the CSE/H2S pathway which related to the reduction of the expression of p-CaM and CyclinD1. Key words: Hydrogen sulfide; Proliferation; Calmodulin; CyclinD1
{"title":"Effect of hydrogen sulfide on the proliferation of rabbit vascular smooth muscle cell under high static pressure","authors":"T. He, Jie Wu, Changsheng Xu, Pian-Pian Chen, Fanggang Cai","doi":"10.3760/CMA.J.CN113855-20190520-00269","DOIUrl":"https://doi.org/10.3760/CMA.J.CN113855-20190520-00269","url":null,"abstract":"Objective \u0000To observe the effect of exogenous hydrogen sulfide(H2S) on the proliferation of rabbit vascular smooth muscle cell(VSMC) under high static pressure. \u0000 \u0000 \u0000Methods \u0000Rabbit thoracic aorta VSMC were isolated and cultured under high static pressure(100mmHg) and divided into control group [cultured with 0.2%fetal bovine serum(FBS) and no NaHS]、10%FBS group(10%FBS and no NaHS) and NaHS group(10%FBS and 50mmol/L NaHS). VSMC proliferation was analyzed with BUDR. CSE, Calmodulin(p-CaM)and CyclinD1 protein levels of VSMC were measured by Western blotting. \u0000 \u0000 \u0000Results \u0000Compared with the 10%FBS group, NaHS inhibit the proliferation of rabbit VSMC significantly (0.50±0.03 vs. 0.26±0.03, P<0.05). Compared with control group, CSE protein in the 10%FBS group decreased significantly(1.21±0.10 vs. 0.33±0.04, P<0.05) and p-CaM and CyclinD1 protein increased significantly(0.23±0.04 vs. 0.86±0.04 and 0.22±0.03 vs. 1.19±0.06, P<0.05). Compared with the 10%FBS group, CSE protein in NaHS group increased significantly(0.33±0.04 vs. 1.11±0.11, P<0.05), and the expression of p-CaM and CyclinD1 protein decreased significantly(0.86±0.04 vs. 0.26±0.05 and 1.19±0.06 vs. 0.51±0.03, P<0.05). \u0000 \u0000 \u0000Conclusion \u0000Exogenous hydrogen sulfide inhibits the proliferation of VSMC under high static pressure by the CSE/H2S pathway which related to the reduction of the expression of p-CaM and CyclinD1. \u0000 \u0000 \u0000Key words: \u0000Hydrogen sulfide; Proliferation; Calmodulin; CyclinD1","PeriodicalId":66425,"journal":{"name":"中华普通外科杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47217435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-25DOI: 10.3760/CMA.J.CN113855-20190923-00565
Junsheng Yang, Yongjin Bao, Weibo Chen, Yong Yang, H. Cai, Y. Duan, Xuemin Chen, Donglin Sun
Objective To evaluate partial splenectomy (LPS) in the treatment of benign solid tumors of the spleen. Methods The clinical data of patients with benign solid tumors of spleen treated by laparoscopy from Jan 2010 to Jun 2018 in the Third Affiliated Hospital of Soochow University was retrospectively analyzed. Patients were divided into LPS group and laparoscopic total splenectomy (LTS) group. Results There were 21 cases in LPS group and 25 cases in LTS group. Differences between the two groups, operative time, blood loss, transfusion rate, maintenance of drain, postoperative hospital stay, costs, postoperative WBC and platelet count, and postoperative complications such as hemorrhage, fever, splenic fossa effusion, pancreatic fistula, venous thrombosis were statistically insignificant. However, the postoperative incidence of thrombocythemia in the LPS group were significantly lower compared to the LTS group (χ2 =4.293, P<0.05). Conclusions Patients with benign solid tumors of the spleen will benefit more from LPS compared to LTS. Key words: Splenic neoplasms; Splenectomy; Laparoscopes
{"title":"Laparoscopic partial splenectomy guided by precise surgery procedures","authors":"Junsheng Yang, Yongjin Bao, Weibo Chen, Yong Yang, H. Cai, Y. Duan, Xuemin Chen, Donglin Sun","doi":"10.3760/CMA.J.CN113855-20190923-00565","DOIUrl":"https://doi.org/10.3760/CMA.J.CN113855-20190923-00565","url":null,"abstract":"Objective \u0000To evaluate partial splenectomy (LPS) in the treatment of benign solid tumors of the spleen. \u0000 \u0000 \u0000Methods \u0000The clinical data of patients with benign solid tumors of spleen treated by laparoscopy from Jan 2010 to Jun 2018 in the Third Affiliated Hospital of Soochow University was retrospectively analyzed. Patients were divided into LPS group and laparoscopic total splenectomy (LTS) group. \u0000 \u0000 \u0000Results \u0000There were 21 cases in LPS group and 25 cases in LTS group. Differences between the two groups, operative time, blood loss, transfusion rate, maintenance of drain, postoperative hospital stay, costs, postoperative WBC and platelet count, and postoperative complications such as hemorrhage, fever, splenic fossa effusion, pancreatic fistula, venous thrombosis were statistically insignificant. However, the postoperative incidence of thrombocythemia in the LPS group were significantly lower compared to the LTS group (χ2 =4.293, P<0.05). \u0000 \u0000 \u0000Conclusions \u0000Patients with benign solid tumors of the spleen will benefit more from LPS compared to LTS. \u0000 \u0000 \u0000Key words: \u0000Splenic neoplasms; Splenectomy; Laparoscopes","PeriodicalId":66425,"journal":{"name":"中华普通外科杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48124229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-25DOI: 10.3760/CMA.J.CN113855-20191209-00724
Wei Zhang, Fei Liu, Lixing Wang, D. Guo, Xin Xu, Bin Chen, Jun‐hao Jiang, Jue Yang, Zhenyu Shi, W. Fu
Objective To evaluate the correlation between tumor size and surgical outcomes of Shamblin Ⅱ/Ⅲ carotid body tumor (CBT) and the prognosis. Methods From Apr 2011 to Dec 2017, 88 patients with Shamblin Ⅱ and Ⅲ CBTs undergoing tumor resection were retrospectively analyzed. The long-term prognosis of surgical resection was also evaluated. Results One patient died of multi-organ failure postoperatively, two patients abandoned surgery. The perioperative mortality was 1%. 85 patients having 87 lesions successfully resected were analyzed. There were 13 Shamblin Ⅱ and 74 Shamblin Ⅲ CBTs resection. Two patients had bilateral CBTs resection. The median of tumor size, procedural blood loss, procedural time, and length of hospital stay was 3.0 (1.2-5.5) cm, 200 (0-2 500) ml, 162 (85-430) min, and 10 (6-28) d, respectively. Seventy-two patients had carotid vascular intervention during the procedure, and thirty-three patients had neurological complications after the procedure. Correlation analysis showed that the tumor size had positive relationship with blood loss (Spearman R=0.35, P<0.01) and procedural time (Spearman R= 0.54, P<0.01). Tumor size was positively associated with the risk of cranial neurological complication (OR=1.72, 95% CI 1.08-2.73, P=0.02) and carotid vascular intervention (OR=2.69, 95% CI 1.27-5.69, P=0.01). There were four patients who were diagnosed with malignant CBT due to the metastasis. Three suffered CBT recurrence after 1, 5, and 7 years during the follow up. Conclusions Shamblin Ⅱ or Ⅲ CBTs should be intervened as early as possible to facilitate the surgical resection, as well as to reduce the risk of carotid vascular and neurological complications. Key words: Carotid body tumor; Vascular surgical procedures; Postoperative complications
目的探讨ShamblinⅡ/Ⅲ颈动脉体瘤(CBT)的肿瘤大小与手术疗效及预后的关系。方法回顾性分析2011年4月至2017年12月行ShamblinⅡ和ⅢCBTs肿瘤切除术的88例患者。并对手术切除的远期预后进行评价。结果1例患者术后多脏器功能衰竭死亡，2例患者放弃手术。围手术期死亡率为1%。本文对85例87个病灶成功切除的病例进行了分析。有13例ShamblinⅡ和74例ShamblinⅢct切除术。2例患者行双侧cbt切除术。肿瘤大小、手术出血量、手术时间和住院时间的中位数分别为3.0 (1.2-5.5)cm、200 (0-2 500)ml、162 (85-430)min和10 (6-28)d。72例患者在手术过程中有颈动脉血管介入，33例患者术后有神经系统并发症。相关分析显示，肿瘤大小与出血量(Spearman R=0.35, P<0.01)和手术时间(Spearman R= 0.54, P<0.01)呈正相关。肿瘤大小与颅神经系统并发症(OR=1.72, 95% CI 1.08-2.73, P=0.02)和颈动脉血管干预(OR=2.69, 95% CI 1.27-5.69, P=0.01)呈正相关。有4例患者因转移而被诊断为恶性CBT。3名患者随访1年、5年和7年后出现CBT复发。结论应尽早干预ShamblinⅡ或Ⅲcbt，以方便手术切除，减少颈动脉血管和神经系统并发症的发生。关键词:颈动脉体瘤;血管外科手术;术后并发症
{"title":"Long-term follow up outcomes of surgical resection of Shamblin II/III carotid body tumor: a single center analysis","authors":"Wei Zhang, Fei Liu, Lixing Wang, D. Guo, Xin Xu, Bin Chen, Jun‐hao Jiang, Jue Yang, Zhenyu Shi, W. Fu","doi":"10.3760/CMA.J.CN113855-20191209-00724","DOIUrl":"https://doi.org/10.3760/CMA.J.CN113855-20191209-00724","url":null,"abstract":"Objective \u0000To evaluate the correlation between tumor size and surgical outcomes of Shamblin Ⅱ/Ⅲ carotid body tumor (CBT) and the prognosis. \u0000 \u0000 \u0000Methods \u0000From Apr 2011 to Dec 2017, 88 patients with Shamblin Ⅱ and Ⅲ CBTs undergoing tumor resection were retrospectively analyzed. The long-term prognosis of surgical resection was also evaluated. \u0000 \u0000 \u0000Results \u0000One patient died of multi-organ failure postoperatively, two patients abandoned surgery. The perioperative mortality was 1%. 85 patients having 87 lesions successfully resected were analyzed. There were 13 Shamblin Ⅱ and 74 Shamblin Ⅲ CBTs resection. Two patients had bilateral CBTs resection. The median of tumor size, procedural blood loss, procedural time, and length of hospital stay was 3.0 (1.2-5.5) cm, 200 (0-2 500) ml, 162 (85-430) min, and 10 (6-28) d, respectively. Seventy-two patients had carotid vascular intervention during the procedure, and thirty-three patients had neurological complications after the procedure. Correlation analysis showed that the tumor size had positive relationship with blood loss (Spearman R=0.35, P<0.01) and procedural time (Spearman R= 0.54, P<0.01). Tumor size was positively associated with the risk of cranial neurological complication (OR=1.72, 95% CI 1.08-2.73, P=0.02) and carotid vascular intervention (OR=2.69, 95% CI 1.27-5.69, P=0.01). There were four patients who were diagnosed with malignant CBT due to the metastasis. Three suffered CBT recurrence after 1, 5, and 7 years during the follow up. \u0000 \u0000 \u0000Conclusions \u0000Shamblin Ⅱ or Ⅲ CBTs should be intervened as early as possible to facilitate the surgical resection, as well as to reduce the risk of carotid vascular and neurological complications. \u0000 \u0000 \u0000Key words: \u0000Carotid body tumor; Vascular surgical procedures; Postoperative complications","PeriodicalId":66425,"journal":{"name":"中华普通外科杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42278808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-25DOI: 10.3760/CMA.J.CN113855-20190824-00492
Jiye Zhang, Zhifei Wang, Junwei Liu, Yi Lu, Kai Jiang, L. Zhang
Objective To evaluate the effect of laparoscopic hiatal hernia repair plus fundoplication on gastroesophageal reflux disease (GERD). Methods The clinical data of 206 GERD patients with esophageal hiatal hernia treated by laparoscopic esophageal hiatal hernia repair + fundoplication at the gastroesophageal reflux center of Zhejiang People′s Hospital from Jan 2016 to Jun 2019 was retrospectively analyzed, including basic data, symptom score, auxiliary examination and follow-up. Results All 206 patients underwent laparoscopic anti-reflux surgery successfully. There was no conversion to open surgery and no death. Preoperative Deemester scores were 46.49±37.42, while Deemester score 6 month after surgery were 6.38±4.69.Mean follow-up time was 15 months and good result were achieved in 98% of follow-up cases. Conclusion Laparoscopic repair plus fundoplication for GERD is of minimally invasive and satisfactory, while the preoperative evaluation of surgical indications is properly conducted. Key words: Hernia, hiatal; Herniorrhaphy; Fundoplication; Laparoscopes
{"title":"Laparoscopic hiatal hernia repair plus fundoplication for gastroesophageal reflux disease: report of 206 cases","authors":"Jiye Zhang, Zhifei Wang, Junwei Liu, Yi Lu, Kai Jiang, L. Zhang","doi":"10.3760/CMA.J.CN113855-20190824-00492","DOIUrl":"https://doi.org/10.3760/CMA.J.CN113855-20190824-00492","url":null,"abstract":"Objective To evaluate the effect of laparoscopic hiatal hernia repair plus fundoplication on gastroesophageal reflux disease (GERD). Methods The clinical data of 206 GERD patients with esophageal hiatal hernia treated by laparoscopic esophageal hiatal hernia repair + fundoplication at the gastroesophageal reflux center of Zhejiang People′s Hospital from Jan 2016 to Jun 2019 was retrospectively analyzed, including basic data, symptom score, auxiliary examination and follow-up. Results All 206 patients underwent laparoscopic anti-reflux surgery successfully. There was no conversion to open surgery and no death. Preoperative Deemester scores were 46.49±37.42, while Deemester score 6 month after surgery were 6.38±4.69.Mean follow-up time was 15 months and good result were achieved in 98% of follow-up cases. Conclusion Laparoscopic repair plus fundoplication for GERD is of minimally invasive and satisfactory, while the preoperative evaluation of surgical indications is properly conducted. Key words: Hernia, hiatal; Herniorrhaphy; Fundoplication; Laparoscopes","PeriodicalId":66425,"journal":{"name":"中华普通外科杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49504693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-25DOI: 10.3760/CMA.J.CN113855-20200119-00039
Guangchao Gu, Zhi-li Liu, Bao Liu, Changwei Liu, W. Ye, Yuexin Chen, L. Ni, R. Zeng, J. Shao, Xiao-jun Song, Yue-hong Zheng
Objective To summarize the surgical treatment of malignant carotid body tumor (MCBT). Methods A retrospective analysis of 14 MCBT patients admitted at our hospital from Mar 2005 to Nov 2019 was made, and the imaging data, surgical records, perioperative complications and follow-up data were collected. Results There were 8 males and 6 females, with an average age of (40.8±11.3) years. 10 patients underwent surgical resection of CBT, with one case undergoing tumor enucleation only, nine cases underwent internal carotid artery reconstruction, and all patients underwent intraoperative lymph node biopsy.Tumors were completely removed in all 10 patients. No perioperative death or cerebral infarction occurred. The intraoperative blood loss was (955±658.5) ml. Four patients had permanent nerve injury after surgery. The follow-up time ranged 1-132 months. There were no cases of cerebral infarction or death, and the reconstructed graft remained patent. Apart from the 2 patients who developed tumor metastasis after surgery, other patients recovered uneventfully with no disease progression. Conclusions Surgery is still the main treatment for MCBT, but MCBT is large and Shamblin class is more advanced. Therefore, complete tumor removal and reconstruction of the carotid arteries are difficult. Surgery should seek to completely remove the tumor and neck lymph node biopsy should be performed to determine the lymph node metastasis. Key words: Carotid body tumor; Vascular surgical procedures
{"title":"Surgical treatment of malignant carotid body tumor","authors":"Guangchao Gu, Zhi-li Liu, Bao Liu, Changwei Liu, W. Ye, Yuexin Chen, L. Ni, R. Zeng, J. Shao, Xiao-jun Song, Yue-hong Zheng","doi":"10.3760/CMA.J.CN113855-20200119-00039","DOIUrl":"https://doi.org/10.3760/CMA.J.CN113855-20200119-00039","url":null,"abstract":"Objective \u0000To summarize the surgical treatment of malignant carotid body tumor (MCBT). \u0000 \u0000 \u0000Methods \u0000A retrospective analysis of 14 MCBT patients admitted at our hospital from Mar 2005 to Nov 2019 was made, and the imaging data, surgical records, perioperative complications and follow-up data were collected. \u0000 \u0000 \u0000Results \u0000There were 8 males and 6 females, with an average age of (40.8±11.3) years. 10 patients underwent surgical resection of CBT, with one case undergoing tumor enucleation only, nine cases underwent internal carotid artery reconstruction, and all patients underwent intraoperative lymph node biopsy.Tumors were completely removed in all 10 patients. No perioperative death or cerebral infarction occurred. The intraoperative blood loss was (955±658.5) ml. Four patients had permanent nerve injury after surgery. The follow-up time ranged 1-132 months. There were no cases of cerebral infarction or death, and the reconstructed graft remained patent. Apart from the 2 patients who developed tumor metastasis after surgery, other patients recovered uneventfully with no disease progression. \u0000 \u0000 \u0000Conclusions \u0000Surgery is still the main treatment for MCBT, but MCBT is large and Shamblin class is more advanced. Therefore, complete tumor removal and reconstruction of the carotid arteries are difficult. Surgery should seek to completely remove the tumor and neck lymph node biopsy should be performed to determine the lymph node metastasis. \u0000 \u0000 \u0000Key words: \u0000Carotid body tumor; Vascular surgical procedures","PeriodicalId":66425,"journal":{"name":"中华普通外科杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45140063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：