ALSU咨询编号52:谷胱甘肽

IF 2.5 4区 医学 Q2 CLINICAL NEUROLOGY Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration Pub Date : 2019-11-29 DOI:10.1080/21678421.2019.1697029
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引用次数: 1

摘要

谷胱甘肽是一种天然存在的抗氧化剂,可帮助细胞清除有害的自由基(2)。它是“谷胱甘肽系统”的一部分,其中包括有助于合成谷胱甘肽的化学物质以及利用谷胱甘肽对抗氧化应激的化学物质(3)。谷胱甘肽以不同的形式存在,包括称为GSH的活性(还原)形式和称为谷胱甘肽二硫化物(GSSG)的废(氧化)形式;GSH保护细胞,而GSSG升高表明氧化应激恶化(2)。GSH本身可作为口服、鼻内、吸入或注射补充剂。这些配方在网站上被宣传为ALS的治疗方法(4,5)。一些含有半胱氨酸的补充剂,如免疫和N-乙酰半胱氨酸(NAC),用于增加细胞内GSH(3,6,7),因此它们在治疗ALS中的潜在作用也将在这里进行综述。
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ALSUntangled No. 52: Glutathione
Glutathione is a naturally occurring antioxidant which helps cells eliminate damaging free radicals (2). It is part of the “glutathione system” which includes chemicals that help synthesize glutathione as well as chemicals that use glutathione to fight oxidative stress (3). Glutathione exists in different forms including the active (reduced) form referred to as GSH, and the spent (oxidized) form referred to as glutathione disulfide (GSSG); GSH protects cells while rising GSSG indicates worsening oxidative stress (2). GSH itself is available as an oral, intranasal, inhaled or injectable supplement. These formulations are advertised on websites as a treatment for ALS (4,5). Some cysteine-containing supplements such as Immunocal and N-acetylcysteine (NAC) are used to increase intracellular GSH (3,6,7) and so their potential role in treating ALS will also be reviewed here.
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来源期刊
CiteScore
5.40
自引率
10.70%
发文量
64
期刊介绍: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration is an exciting new initiative. It represents a timely expansion of the journal Amyotrophic Lateral Sclerosis in response to the clinical, imaging pathological and genetic overlap between ALS and frontotemporal dementia. The expanded journal provides outstanding coverage of research in a wide range of issues related to motor neuron diseases, especially ALS (Lou Gehrig’s disease) and cognitive decline associated with frontotemporal degeneration. The journal also covers related disorders of the neuroaxis when relevant to these core conditions.
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