COX2/PGE2炎症通路对γ射线照射大鼠褐藻提取物的反应

K. Azab, N. Meky, Eglal A. M. El-Deghidy, Ghada Azoz
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引用次数: 6

摘要

背景:辐射暴露引起的全身性炎症在生物系统中已被确定为某些代谢和行为障碍。这些无政府状态主要是在环氧化酶2 (COX2)诱导炎症介质前列腺素E2 (PGE2)产生的调节下介导的。目的:研究褐海草提取物(BSWE)对γ辐照大鼠COX2/PGE2炎症通路的抗炎作用。大鼠连续7天口服BSWE (27 mg/kg体重/天),然后暴露于8 Gy分次γ辐射(2 Gy × 4;每3天)。BSWE治疗随辐照剂量和中间剂量延长,再连续14天。我们的数据表明,按照建议的方案,给暴露于伽马辐射的大鼠服用BSWE,可以显著中和炎症分子COX2、PGE2、肿瘤坏死α (TNF-α)和一氧化氮(NO)的变化。此外,它还通过调节丙二醛(MDA)还原谷胱甘肽(GSH)、超氧化物歧化酶(SOD)过氧化氢酶(CAT)和黄嘌呤氧化还原酶系统(XOR)的变化,显著调节细胞氧化还原张力。可信的是,从本研究的结果可以看出,BSWE具有实质性的抗炎活性和γ辐射防护能力。建议将BSWE作为一种安全的天然抗炎剂纳入各种炎症性疾病特别是癌症的治疗策略中。
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Response of COX2/PGE2 Inflammatory Pathway to Brown Seaweed Extract in Rats Exposed to Gamma Radiation
Background: Systemic inflammation due to radiation exposure has been identified in a biological system by certain metabolic and behavioral disorders. These anarchies mostly mediated under a regulation of cyclooxygenase 2 (COX2) induced production of an inflammatory mediator prostaglandin E2 (PGE2). Aim: This study was undertaken to investigate the anti-inflammatory impact of brown sea weed extract (BSWE) against induction of COX2/PGE2 inflammatory pathway in gamma-irradiated rats. Rats were orally administrated with BSWE (27 mg/kg body weight/day) for 7 consecutive days before exposure to 8 Gy fractionated gamma radiation (2 Gy × 4; every 3 days). Treatment with BSWE was extended along with and in-between irradiation doses for another 14 successive days. Our data demonstrated that the administration of BSWE to rats exposed to gamma radiation, following the regimen suggested, significantly neutralize the changes induced in the inflammatory molecules COX2, PGE2, tumor necrosis alpha (TNF-α), and nitric oxide (NO). In addition, it adjusted significantly the cellular redox tone via regulation of changes induced in malondialdehyde (MDA) reduced glutathione (GSH), superoxide dismutase (SOD) catalase (CAT) and xanthine oxidoreductase system (XOR). Credibly, from the results emerged in this study, it could be suggested that BSWE has substantial anti-inflammatory activities and gamma radiation protection capabilities. It is recommended to include BSWE in the treatment strategy of various inflammatory diseases especially cancer as a safe natural anti-inflammatory agent.
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