Reduction of Nitro Compounds, Through different Reaction Conditions (Combinatory Chemistry)

In this work we intend to approach the study of the chemo-selectivity of a transformation on a polyfunctional compound. An example of how the result of a reaction depends on experimental conditions, different nitrated compounds reduction, will be shown. The reduction reaction was carried out under different conditions found in the literature; they were applied to 1,3-dinitrobenzene and to 4-nitroacetophenone. The reduction conditions were: Zn/NH4Cl, hydrazine and 10% Pd/C, NaBH4 and 10% Pd/C in water, Sn/HCl, NaBH4/ethanol, Na2Sx·9H2O-sulfur (0.2 g to 1.0 g) at different time periods. These reagents preferably affect one of the functional groups present. Key word: Reduction of nitro compounds.