J.C. Ceballos-Pomares , S. Cuéllar-Rufino , M.F. Vazquez-Ortega , J. López-Dominguez , V. Romero-Cruz , A.L. Calderón-Garcidueñas
{"title":"先天性恰加斯病的免疫学","authors":"J.C. Ceballos-Pomares , S. Cuéllar-Rufino , M.F. Vazquez-Ortega , J. López-Dominguez , V. Romero-Cruz , A.L. Calderón-Garcidueñas","doi":"10.1016/j.rprh.2018.01.001","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><p>In Latin America approximately 1,125,000 women of childbearing age are infected with <em>Trypanosoma cruzi.</em></p></div><div><h3>Methodology</h3><p>A review of the literature was carried out on the immunology of congenital Chagas’ disease.</p></div><div><h3>Results</h3><p>In this country, <em>T.<!--> <!-->cruzi</em> TcI predominates. IFN-γ is the key cytokine in infection control. The macrophages of infected women who transmit the disease are less activated and release less TNF-α than those of infected women who do not transmit the disease. They also have a lower capacity to produce IFN-γ in response to <em>T.<!--> <!-->cruzi</em>. Severe parasitaemia favours congenital infection.</p></div><div><h3>Conclusions</h3><p>There are different immunological factors that involve the parasite, the maternal and foetal immune system, and the placental barrier.</p></div>","PeriodicalId":32275,"journal":{"name":"Perinatologia y Reproduccion Humana","volume":"31 3","pages":"Pages 144-150"},"PeriodicalIF":0.0000,"publicationDate":"2017-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rprh.2018.01.001","citationCount":"2","resultStr":"{\"title\":\"Inmunología de la enfermedad de Chagas congénita\",\"authors\":\"J.C. Ceballos-Pomares , S. Cuéllar-Rufino , M.F. Vazquez-Ortega , J. López-Dominguez , V. Romero-Cruz , A.L. Calderón-Garcidueñas\",\"doi\":\"10.1016/j.rprh.2018.01.001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Introduction</h3><p>In Latin America approximately 1,125,000 women of childbearing age are infected with <em>Trypanosoma cruzi.</em></p></div><div><h3>Methodology</h3><p>A review of the literature was carried out on the immunology of congenital Chagas’ disease.</p></div><div><h3>Results</h3><p>In this country, <em>T.<!--> <!-->cruzi</em> TcI predominates. IFN-γ is the key cytokine in infection control. The macrophages of infected women who transmit the disease are less activated and release less TNF-α than those of infected women who do not transmit the disease. They also have a lower capacity to produce IFN-γ in response to <em>T.<!--> <!-->cruzi</em>. Severe parasitaemia favours congenital infection.</p></div><div><h3>Conclusions</h3><p>There are different immunological factors that involve the parasite, the maternal and foetal immune system, and the placental barrier.</p></div>\",\"PeriodicalId\":32275,\"journal\":{\"name\":\"Perinatologia y Reproduccion Humana\",\"volume\":\"31 3\",\"pages\":\"Pages 144-150\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2017-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.rprh.2018.01.001\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Perinatologia y Reproduccion Humana\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0187533718300013\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Perinatologia y Reproduccion Humana","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0187533718300013","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
In Latin America approximately 1,125,000 women of childbearing age are infected with Trypanosoma cruzi.
Methodology
A review of the literature was carried out on the immunology of congenital Chagas’ disease.
Results
In this country, T. cruzi TcI predominates. IFN-γ is the key cytokine in infection control. The macrophages of infected women who transmit the disease are less activated and release less TNF-α than those of infected women who do not transmit the disease. They also have a lower capacity to produce IFN-γ in response to T. cruzi. Severe parasitaemia favours congenital infection.
Conclusions
There are different immunological factors that involve the parasite, the maternal and foetal immune system, and the placental barrier.
期刊介绍：
Perinatología y Reproducción Humana is the official journal of the Instituto Nacional de Perinatología, Mexico. It is aimed at physicians of the area of perinatal and reproductive health (obstetrics and gynecology, maternal and fetal medicine, pediatricians, neonatologists, endocrinologists, infectious disease specialists, and neurologists) and also at health sciences professionals involved in the study of reproduction perinatal and reproductive health (chemists, biologists and neuro-physiologists). It is an electronic biannual journal, that publishes peer-reviewed original articles, in-deep reviews, letters to the editor and special sections related to basic, epidemiological, surgical, and clinical aspects in the area of perinatal and reproductive health, in English or Spanish languages and open access.
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