Resultados perinatales en mujeres mexicanas con lupus eritematoso sistémico

Objective

To determine the perinatal outcomes among Mexican women with singleton pregnancy and systemic lupus erythematosus.

Material and methods

Historical cohort study on women diagnosed with systemic lupus erythematosus, singleton pregnancy, prenatal care, and resolution between 2010 and 2015. The incidence of the following perinatal outcomes was calculated: pre-term birth, stillbirth, oligohydramnios, miscarriage, premature rupture of membranes, gestational hypertension, preeclampsia, intrauterine growth restriction, and congenital defects.

Results

A total of 122 women were included. The characteristics of the study population at admission and resolution were: maternal age 26.2 ± 6 years, maternal weight 63.4 ± 11.1 kg, body mass index 26 ± 3.9 kg/ m², number of gestations 1.9 ± 1.2, gestational weeks at admission 16.6 ± 6.5, gestational weeks at resolution 36.1 ± 3.4, neonatal weight 2,417-770 g. The incidence of adverse perinatal outcomes was: pre-term birth 41.8%, death 1.6%, oligohydramnios 6.6%, miscarriage 5.7%, premature rupture of membranes 9.8%, gestational hypertension 5.7%, preeclampsia 24.6%, early onset preeclampsia 15.6%, anaemia 23%, intrauterine growth restriction 14.7%, congenital defects 2.4%, and caesarean 78.2%.

Conclusions

Mexican women with systemic lupus erythematosus have high incidence of pre-term birth, preeclampsia, anaemia, early onset preeclampsia, intrauterine growth restriction, oligohydramnios and caesarean. Furthermore, the incidence of live births is among the highest reported in the literature.