Shengfang Chen, Chun-li Cui, Haoming Song, Lei Lin
{"title":"老年患者血清尿酸水平与心血管疾病风险的决定因素","authors":"Shengfang Chen, Chun-li Cui, Haoming Song, Lei Lin","doi":"10.3760/CMA.J.ISSN.1674-635X.2018.04.009","DOIUrl":null,"url":null,"abstract":"Objective \nTo explore the determinants of serum uric acid (UA) levels and the relationship between UA and cardiovascular disease in elderly patients. \n \n \nMethods \nA cross-sectional design was used. A total of 1 066 elderly patients were consecutively recruited in the study. Anthropometric measurement and lifestyle survey were performed, and serum UA, lipid profile, glucose, homocysteine (Hcy) and superoxide dismutase (SOD) were measured. The determinants of serum UA levels and correlation between UA and cardiovascular disease were analyzed by regression. \n \n \nResults \nThe prevalence of hyperuricemia was 21.9% (25.9% in men and 18.7% in women). Partial correlation analysis showed the level of serum UA was positively correlated with Hcy (r=0.163, P=0.000), body mass index(r=0.128, P=0.004) and triglyceride(r=0.133, P=0.003), and negatively correlated with HDL-C (r=-0.103, P=0.021). After adjustment for potential confounding factors, multivariate analysis showed eGFR (β=-2.044, t=-10.544, P=0.000), gender (β=42.065, t=4.700, P=0.000), Hcy (β=1.367, t=3.714, P=0.000), BMI (β=3.370, t=2.706, P=0.007), TG (β=14.120, t=2.589, P=0.010) and SOD (β=-0.636, t=-3.079, P=0.002) were independent determinants for UA levels in elderly patients. Logistic regression analysis indicated that mild elevation of UA levels was a risk factor of hypertension (OR=1.925, 95% CI=1.124-3.295) in women and OR=1.780(95% CI=1.010-3.136) in men]. High UA levels increased the risk of coronary heart disease in women [OR=1.710 (95% CI=1.157-2.526)], but decreased the risk of ischemic stroke in men [OR=0.524(95% CI=0.335-0.820)]. \n \n \nConclusions \nIn elderly patients, serum UA levels were affected by renal function, gender, BMI and serum Hcy, TG and SOD. Mildly elevated UA levels increased the risk of hypertension. High UA levels increased the risk of coronary heart disease in women and decreased the risk of ischemic stroke in men. \n \n \nKey words: \nElderly patients; Uric acid; Hypertension; Coronary heart disease; Ischemic stroke","PeriodicalId":9877,"journal":{"name":"中华临床营养杂志","volume":"26 1","pages":"245-250"},"PeriodicalIF":0.0000,"publicationDate":"2018-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Determinants of serum uric acid levels and risk for cardiovascular disease in elderly patients\",\"authors\":\"Shengfang Chen, Chun-li Cui, Haoming Song, Lei Lin\",\"doi\":\"10.3760/CMA.J.ISSN.1674-635X.2018.04.009\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objective \\nTo explore the determinants of serum uric acid (UA) levels and the relationship between UA and cardiovascular disease in elderly patients. \\n \\n \\nMethods \\nA cross-sectional design was used. A total of 1 066 elderly patients were consecutively recruited in the study. Anthropometric measurement and lifestyle survey were performed, and serum UA, lipid profile, glucose, homocysteine (Hcy) and superoxide dismutase (SOD) were measured. The determinants of serum UA levels and correlation between UA and cardiovascular disease were analyzed by regression. \\n \\n \\nResults \\nThe prevalence of hyperuricemia was 21.9% (25.9% in men and 18.7% in women). Partial correlation analysis showed the level of serum UA was positively correlated with Hcy (r=0.163, P=0.000), body mass index(r=0.128, P=0.004) and triglyceride(r=0.133, P=0.003), and negatively correlated with HDL-C (r=-0.103, P=0.021). After adjustment for potential confounding factors, multivariate analysis showed eGFR (β=-2.044, t=-10.544, P=0.000), gender (β=42.065, t=4.700, P=0.000), Hcy (β=1.367, t=3.714, P=0.000), BMI (β=3.370, t=2.706, P=0.007), TG (β=14.120, t=2.589, P=0.010) and SOD (β=-0.636, t=-3.079, P=0.002) were independent determinants for UA levels in elderly patients. Logistic regression analysis indicated that mild elevation of UA levels was a risk factor of hypertension (OR=1.925, 95% CI=1.124-3.295) in women and OR=1.780(95% CI=1.010-3.136) in men]. High UA levels increased the risk of coronary heart disease in women [OR=1.710 (95% CI=1.157-2.526)], but decreased the risk of ischemic stroke in men [OR=0.524(95% CI=0.335-0.820)]. \\n \\n \\nConclusions \\nIn elderly patients, serum UA levels were affected by renal function, gender, BMI and serum Hcy, TG and SOD. Mildly elevated UA levels increased the risk of hypertension. 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Determinants of serum uric acid levels and risk for cardiovascular disease in elderly patients
Objective
To explore the determinants of serum uric acid (UA) levels and the relationship between UA and cardiovascular disease in elderly patients.
Methods
A cross-sectional design was used. A total of 1 066 elderly patients were consecutively recruited in the study. Anthropometric measurement and lifestyle survey were performed, and serum UA, lipid profile, glucose, homocysteine (Hcy) and superoxide dismutase (SOD) were measured. The determinants of serum UA levels and correlation between UA and cardiovascular disease were analyzed by regression.
Results
The prevalence of hyperuricemia was 21.9% (25.9% in men and 18.7% in women). Partial correlation analysis showed the level of serum UA was positively correlated with Hcy (r=0.163, P=0.000), body mass index(r=0.128, P=0.004) and triglyceride(r=0.133, P=0.003), and negatively correlated with HDL-C (r=-0.103, P=0.021). After adjustment for potential confounding factors, multivariate analysis showed eGFR (β=-2.044, t=-10.544, P=0.000), gender (β=42.065, t=4.700, P=0.000), Hcy (β=1.367, t=3.714, P=0.000), BMI (β=3.370, t=2.706, P=0.007), TG (β=14.120, t=2.589, P=0.010) and SOD (β=-0.636, t=-3.079, P=0.002) were independent determinants for UA levels in elderly patients. Logistic regression analysis indicated that mild elevation of UA levels was a risk factor of hypertension (OR=1.925, 95% CI=1.124-3.295) in women and OR=1.780(95% CI=1.010-3.136) in men]. High UA levels increased the risk of coronary heart disease in women [OR=1.710 (95% CI=1.157-2.526)], but decreased the risk of ischemic stroke in men [OR=0.524(95% CI=0.335-0.820)].
Conclusions
In elderly patients, serum UA levels were affected by renal function, gender, BMI and serum Hcy, TG and SOD. Mildly elevated UA levels increased the risk of hypertension. High UA levels increased the risk of coronary heart disease in women and decreased the risk of ischemic stroke in men.
Key words:
Elderly patients; Uric acid; Hypertension; Coronary heart disease; Ischemic stroke
期刊介绍：
The Chinese Journal of Clinical Nutrition was founded in 1993. It is the first professional academic journal (bimonthly) in my country co-sponsored by the Chinese Medical Association and the Chinese Academy of Medical Sciences to disseminate information on clinical nutrition support, nutrient metabolism, the impact of nutrition support on outcomes and "cost-effectiveness", as well as translational medicine and nutrition research. It is also a professional journal of the Chinese Medical Association's Parenteral and Enteral Nutrition Branch.
The purpose of the Chinese Journal of Clinical Nutrition is to promote the rapid dissemination of knowledge on nutrient metabolism and the rational application of parenteral and enteral nutrition, focusing on the combination of multidisciplinary and multi-regional field investigations and clinical research. It mainly reports on nutritional risk screening related to the indications of parenteral and enteral nutrition support, "cost-effectiveness" research on nutritional drugs, consensus on clinical nutrition, guidelines, expert reviews, randomized controlled studies, cohort studies, glycoprotein and other nutrient metabolism research, systematic evaluation of clinical research, evidence-based case reports, special reviews, case reports and clinical experience exchanges, etc., and has a special column on new technologies related to the field of clinical nutrition and their clinical applications.
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