基于振荡的细胞培养监测光谱学

IF 1.9 Q3 ENGINEERING, ELECTRICAL & ELECTRONIC Frontiers in electronics Pub Date : 2022-07-22 DOI:10.3389/felec.2022.836669
P. Pérez, Juan A. Serrano-Viseas, Santiago Fernández-Scagliusi, Daniel Martín-Fernández, G. Huertas, A. Yúfera
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引用次数: 0

摘要

生物阻抗是一种与生物样品的状态和固有进化有关的物理性质。在现有的阻抗测量方法中,基于振荡的(OB)测试是一种简单而智能的解决方案,可以间接测量与所产生振荡的振幅和频率相关的阻抗,这些振幅和频率与被测样品成比例。OB测试需要根据每个测量问题得出的规范调整系统块。必须进行OB设置,以获得受测系统、电子接口和测试所用电极施加的特定约束的最佳测量灵敏度。这项工作提出将OB测量系统扩展到光谱测试,使这项技术能够在没有设置电振荡器固定频率限制的情况下实现全新的应用范围。考虑到电极-细胞系统的相应电路接口和电气模型,将为细胞培养物样品的测量提供一些示例。当监测OB系统的特定细胞培养物时,所提出的分析方法允许选择振幅和频率振荡值的最佳灵敏度范围的最佳振荡元件。
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Oscillation-Based Spectroscopy for Cell-Culture Monitorization
Biological Impedance is a physical property related to the state and inherent evolution of biological samples. Among the existing impedance measurement methods, Oscillation-Based (OB) tests are a simple and smart solution to indirectly measure impedance correlated with the amplitude and frequency of the generated oscillation which are proportional to the sample under test. An OB test requires tuning of the system blocks to specifications derived from every measurement problem. The OB setup must be done to obtain the optimum measurement sensitivity for the specific constraints imposed by the system under test, electronic interfaces, and electrodes employed for test. This work proposes the extension of OB measurement systems to spectroscopy test, enabling a completely new range of applications for this technology without the restrictions imposed by setting a fixed frequency on the electrical oscillator. Some examples will be presented to the measurement of cell cultures samples, considering the corresponding circuit interfaces and electric models for the electrode-cell system. The proposed analysis method allows the selection of the best oscillator elements for optimum sensitivity range in amplitude and frequency oscillation values, when a specific cell culture is monitored for the OB system.
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