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Electromagnetic based flexible bioelectronics and its applications 基于电磁的柔性生物电子学及其应用
Pub Date : 2024-04-25 DOI: 10.3389/felec.2024.1240603
Shenyi Pan, Minghao Zhou, Longyin Liu, Huimin Shen
With the increasing demand in seamless interface between artificial devices and biological structures, flexible bioelectronics has been developed rapidly in recent years. Compared with traditional rigid bioelectronics, flexible devices are more adaptable to the integration for various parts both inside and outside of the organism. Significant achievements have been made in biomedical devices, neuroelectronics and wearable devices. With the development of flexible bioelectronics, electromagnetics is becoming a crucial part in signal interference reduction and information transmission or feedback, taking advantages of strong penetration and rapid response in a variety of biological materials. In this review, we focus on the latest developments in electromagnetic based flexible bioelectronics, involving materials, sensation, seamless integration, and power supply, as well as the latest achievements in the fields of external wearables, internal implants, soft robotics and drug delivery system. Based on these, the main challenges facing flexible bioelectronics, are analyzed, including stretchability caused by mismatch between mechanical properties of soft and hard components, biocompatibility, environmental stability, to facilitate the further development of flexible bioelectronics.
随着人工设备与生物结构无缝对接的需求日益增长,柔性生物电子学近年来得到了快速发展。与传统的刚性生物电子器件相比,柔性器件更能适应生物体内外各部分的集成。生物医学设备、神经电子学和可穿戴设备等领域都取得了重大成就。随着柔性生物电子学的发展,电磁学正利用其在各种生物材料中穿透力强、反应迅速的优势,成为减少信号干扰、传输或反馈信息的关键部分。在这篇综述中,我们重点介绍了基于电磁学的柔性生物电子学的最新发展,涉及材料、传感、无缝集成和电源,以及在外部可穿戴设备、内部植入物、软机器人和药物输送系统等领域的最新成果。在此基础上,分析了柔性生物电子学面临的主要挑战,包括软硬元件机械性能不匹配导致的可拉伸性、生物兼容性、环境稳定性等,以促进柔性生物电子学的进一步发展。
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引用次数: 0
Impact of head-down-tilt body position on abdomen resistance for urinary bladder monitory applications 低头倾斜体位对膀胱监测应用中腹部阻力的影响
Pub Date : 2024-03-08 DOI: 10.3389/felec.2024.1238967
T. Freeborn, Shelby Critcher, Gwendolyn L. Hooper
Tissue electrical impedance (or bioimpedance) is a quantity related to the passive, frequency-dependent electrical properties of a biological tissue and is a promising modality for continuous monitoring of relative bladder volume and bladder activity. In this study, the impact of body position [specifically 6° head-down tilt (HDT)] intended to induce fluid redistribution and, therefore, result in a change in the electrical resistance of the abdomen is evaluated. The abdomen resistance (10 kHz–100 kHz) of nine healthy young adults was measured before and after 240 min in a 6° HDT position. Over this period, the resistance increase was not statistically significant even though the average bladder volume increased by 506 mL. It was expected that the abdomen resistance would decrease with an increase in bladder volume over this period. The masking of the expected resistance decrease is attributed to the shift in the fluid from the legs/abdomen to the neck/chest caused by the HDT body position over this period. Overall, this suggests that methods to differentiate bladder volume changes from other types of fluid shifts in the body are needed for resistance-based monitoring under free-living conditions.
组织电阻抗(或生物阻抗)是一个与生物组织的被动、频率相关电特性有关的量,是连续监测膀胱相对容量和膀胱活动的一种有前途的模式。本研究评估了体位(特别是 6° 头朝下倾斜 (HDT))的影响,体位的目的是诱导液体重新分布,从而导致腹部电阻的变化。在保持 6° HDT 体位 240 分钟前后,测量了 9 名健康年轻人的腹部电阻(10 kHz-100 kHz)。在此期间,尽管膀胱的平均容量增加了 506 毫升,但电阻的增加在统计学上并不显著。预计在此期间,腹部阻力会随着膀胱容量的增加而降低。预期阻力下降被掩盖的原因是,在此期间,HDT 体位导致液体从腿部/腹部转移到颈部/胸部。总之,这表明在自由生活条件下进行基于阻力的监测时,需要有方法将膀胱容量变化与体内其他类型的液体转移区分开来。
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引用次数: 0
Hardware acceleration of DNA pattern matching using analog resistive CAMs 使用模拟电阻式 CAM 对 DNA 图案匹配进行硬件加速
Pub Date : 2024-02-12 DOI: 10.3389/felec.2023.1343612
Jinane Bazzi, Jana Sweidan, M. Fouda, R. Kanj, Ahmed M. Eltawil
DNA pattern matching is essential for many widely used bioinformatics applications. Disease diagnosis is one of these applications since analyzing changes in DNA sequences can increase our understanding of possible genetic diseases. The remarkable growth in the size of DNA datasets has resulted in challenges in discovering DNA patterns efficiently in terms of run time and power consumption. In this paper, we propose an efficient pipelined hardware accelerator that determines the chance of the occurrence of repeat-expansion diseases using DNA pattern matching. The proposed design parallelizes the DNA pattern matching task using associative memory realized with analog content-addressable memory and implements an algorithm that returns the maximum number of consecutive occurrences of a specific pattern within a DNA sequence. We fully implement all the required hardware circuits with PTM 45-nm technology, and we evaluate the proposed architecture on a practical human DNA dataset. The results show that our design is energy-efficient and accelerates the DNA pattern matching task by more than 100× compared to the approaches described in the literature.
DNA 模式匹配对于许多广泛应用的生物信息学应用至关重要。疾病诊断就是其中一种应用,因为分析 DNA 序列的变化可以加深我们对可能的遗传疾病的了解。DNA 数据集规模的显著增长给高效发现 DNA 模式带来了运行时间和功耗方面的挑战。在本文中,我们提出了一种高效的流水线硬件加速器,可利用 DNA 模式匹配确定重复扩展疾病的发生几率。所提出的设计利用模拟内容可寻址存储器实现的关联存储器对 DNA 模式匹配任务进行了并行化,并实现了一种返回 DNA 序列中特定模式连续出现最大次数的算法。我们采用 PTM 45 纳米技术完全实现了所有必要的硬件电路,并在一个实用的人类 DNA 数据集上对所提出的架构进行了评估。结果表明,我们的设计非常节能,与文献中描述的方法相比,DNA 图案匹配任务的速度提高了 100 倍以上。
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引用次数: 0
Hardware acceleration of DNA pattern matching using analog resistive CAMs 使用模拟电阻式 CAM 对 DNA 图案匹配进行硬件加速
Pub Date : 2024-02-12 DOI: 10.3389/felec.2023.1343612
Jinane Bazzi, Jana Sweidan, M. Fouda, R. Kanj, Ahmed M. Eltawil
DNA pattern matching is essential for many widely used bioinformatics applications. Disease diagnosis is one of these applications since analyzing changes in DNA sequences can increase our understanding of possible genetic diseases. The remarkable growth in the size of DNA datasets has resulted in challenges in discovering DNA patterns efficiently in terms of run time and power consumption. In this paper, we propose an efficient pipelined hardware accelerator that determines the chance of the occurrence of repeat-expansion diseases using DNA pattern matching. The proposed design parallelizes the DNA pattern matching task using associative memory realized with analog content-addressable memory and implements an algorithm that returns the maximum number of consecutive occurrences of a specific pattern within a DNA sequence. We fully implement all the required hardware circuits with PTM 45-nm technology, and we evaluate the proposed architecture on a practical human DNA dataset. The results show that our design is energy-efficient and accelerates the DNA pattern matching task by more than 100× compared to the approaches described in the literature.
DNA 模式匹配对于许多广泛应用的生物信息学应用至关重要。疾病诊断就是其中一种应用,因为分析 DNA 序列的变化可以加深我们对可能的遗传疾病的了解。DNA 数据集规模的显著增长给高效发现 DNA 模式带来了运行时间和功耗方面的挑战。在本文中,我们提出了一种高效的流水线硬件加速器,可利用 DNA 模式匹配确定重复扩展疾病的发生几率。所提出的设计利用模拟内容可寻址存储器实现的关联存储器对 DNA 模式匹配任务进行了并行化,并实现了一种返回 DNA 序列中特定模式连续出现最大次数的算法。我们采用 PTM 45 纳米技术完全实现了所有必要的硬件电路,并在一个实用的人类 DNA 数据集上对所提出的架构进行了评估。结果表明,我们的设计非常节能,与文献中描述的方法相比,DNA 图案匹配任务的速度提高了 100 倍以上。
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引用次数: 0
Editorial: Electromagnetic compatibility design and power electronics technologies in modern power systems 编辑:现代电力系统中的电磁兼容性设计和电力电子技术
Pub Date : 2024-02-05 DOI: 10.3389/felec.2024.1369853
Jian Zhang, Liang Yuan, Yonglu Liu, Jingjie Huang, Carlos Ugalde Loo
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引用次数: 0
Editorial: Electromagnetic compatibility design and power electronics technologies in modern power systems 编辑:现代电力系统中的电磁兼容性设计和电力电子技术
Pub Date : 2024-02-05 DOI: 10.3389/felec.2024.1369853
Jian Zhang, Liang Yuan, Yonglu Liu, Jingjie Huang, Carlos Ugalde Loo
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引用次数: 0
Stable operating limits and improvement methods for hydropower and photovoltaic integration through MMC-HVDC systems 通过 MMC-HVDC 系统实现水电和光伏一体化的稳定运行极限和改进方法
Pub Date : 2024-01-16 DOI: 10.3389/felec.2023.1342795
Maolan Peng, Lei Feng, Shuwen Zhang, Wei Zhao
This paper addresses the critical need to determine the stable operating limit of modular multilevel converter-based high voltage direct current (MMC-HVDC) systems, particularly concerning the integration of extensive renewable energy sources. To achieve this, the steady-state mathematical model and state-space model of bundled hydropower and photovoltaic integration through MMC-HVDC systems are established. A novel methodology considering steady-state and small-signal stability constraints is proposed to compute the stable operating region of the system. The quantitative assessment reveals that diminishing AC system short-circuit capacities amplify restrictions from small-signal stability constraints, thereby reducing the system's stable operating region. Eigenvalue and participation factor analyses shed light on the pivotal factors affecting small-signal stability in weak AC systems. To expand the system's stable operating region, a supplementary frequency damping control strategy is proposed. The theoretical analysis and calculation results are validated by building a simulation model for the bundled hydropower and photovoltaic integration through MMC-HVDC systems in PSCAD/EMTDC.
本文论述了确定基于模块化多电平转换器的高压直流(MMC-HVDC)系统稳定运行极限的关键需求,尤其是在集成大量可再生能源方面。为此,建立了通过 MMC-HVDC 系统集成水电和光伏发电的稳态数学模型和状态空间模型。考虑到稳态和小信号稳定性约束,提出了一种计算系统稳定运行区域的新方法。定量评估显示,交流系统短路容量的减少会放大小信号稳定性约束的限制,从而缩小系统的稳定运行区域。特征值和参与因子分析揭示了影响弱交流系统小信号稳定性的关键因素。为了扩大系统的稳定运行区域,提出了一种辅助频率阻尼控制策略。通过在 PSCAD/EMTDC 中建立 MMC-HVDC 系统捆绑水电和光伏集成的仿真模型,验证了理论分析和计算结果。
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引用次数: 0
Demonstration of transfer learning using 14 nm technology analog ReRAM array 利用 14 纳米技术模拟 ReRAM 阵列演示迁移学习
Pub Date : 2024-01-15 DOI: 10.3389/felec.2023.1331280
F. F. Athena, Omobayode Fagbohungbe, Nanbo Gong, M. Rasch, Jimmy Penaloza, SoonCheon Seo, Arthur R Gasasira, P. Solomon, Valeria Bragaglia, S. Consiglio, H. Higuchi, Chanro Park, K. Brew, Paul Jamison, C. Catano, Iqbal Saraf, Claire Silvestre, Xuefeng Liu, Babar Khan, Nikhil Jain, Steven McDermott, Rick Johnson, I. Estrada-Raygoza, Juntao Li, T. Gokmen, Ning Li, Ruturaj Pujari, Fabio Carta, H. Miyazoe, Martin M. Frank, Antonio La Porta, D. Koty, Qingyun Yang, R. Clark, K. Tapily, C. Wajda, A. Mosden, Jeff Shearer, Andrew Metz, S. Teehan, N. Saulnier, B. Offrein, T. Tsunomura, G. Leusink, Vijay Narayanan, Takashi Ando
Analog memory presents a promising solution in the face of the growing demand for energy-efficient artificial intelligence (AI) at the edge. In this study, we demonstrate efficient deep neural network transfer learning utilizing hardware and algorithm co-optimization in an analog resistive random-access memory (ReRAM) array. For the first time, we illustrate that in open-loop deep neural network (DNN) transfer learning for image classification tasks, convergence rates can be accelerated by approximately 3.5 times through the utilization of co-optimized analog ReRAM hardware and the hardware-aware Tiki-Taka v2 (TTv2) algorithm. A simulation based on statistical 14 nm CMOS ReRAM array data provides insights into the performance of transfer learning on larger network workloads, exhibiting notable improvement over conventional training with random initialization. This study shows that analog DNN transfer learning using an optimized ReRAM array can achieve faster convergence with a smaller dataset compared to training from scratch, thus augmenting AI capability at the edge.
面对日益增长的边缘高能效人工智能(AI)需求,模拟存储器提供了一种前景广阔的解决方案。在本研究中,我们利用模拟电阻式随机存取存储器(ReRAM)阵列中的硬件和算法协同优化,展示了高效的深度神经网络转移学习。我们首次证明,在用于图像分类任务的开环深度神经网络(DNN)迁移学习中,通过利用共同优化的模拟 ReRAM 硬件和硬件感知 Tiki-Taka v2 (TTv2) 算法,收敛速度可加快约 3.5 倍。基于 14 nm CMOS ReRAM 阵列数据统计的仿真深入揭示了迁移学习在更大网络工作负载上的性能,与采用随机初始化的传统训练相比,迁移学习的性能有了显著提高。这项研究表明,与从头开始训练相比,使用优化 ReRAM 阵列的模拟 DNN 转移学习能以更小的数据集实现更快的收敛,从而增强边缘人工智能能力。
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引用次数: 0
A new e-health cloud-based system for cardiovascular risk assessment 基于云的心血管风险评估电子健康新系统
Pub Date : 2023-12-22 DOI: 10.3389/felec.2023.1315132
G. Tatsis, G. Baldoumas, V. Christofilakis, P. Kostarakis, P. Varotsos, N. Sarlis, E. Skordas, A. Bechlioulis, L. Michalis, K. K. Naka
Sudden cardiac death (SCD) is one of the leading causes of death worldwide. Many individuals have no cardiovascular symptoms before the SCD event. As a result, the ability to identify the risk before such an event is extremely limited. Timely and accurate prediction of SCD using new electronic technologies is greatly needed. In this work, a new innovative e-health cloud-based system is presented that allows a stratification of SCD risk based on the method of natural time entropy variability analysis. This innovative, non-invasive system can be used easily in any setting. The e-health cloud-based system was evaluated using data from a total of 203 individuals, patients with chronic heart failure (CHF) who are at high risk of SCD and age-matched healthy controls. Statistical analysis was performed in two-time windows of different duration; the first-time window had a duration of 20 min, while the second was 10 min. Employing modern methods of machine learning, classifiers for the discrimination of CHF patients from the healthy controls were obtained for the first as well as the second (half-time) window. The results indicated a very good separation between the two groups, even from samples taken in a 10-min time window. Larger studies are needed to further validate this novel e-health cloud-based system before its use in everyday clinical practice.
心脏性猝死(SCD)是导致全球死亡的主要原因之一。许多人在 SCD 事件发生前没有任何心血管症状。因此,在此类事件发生前识别风险的能力极其有限。我们亟需利用新的电子技术及时准确地预测 SCD。在这项工作中,介绍了一种基于云的新型创新电子健康系统,该系统可根据自然时间熵变异性分析方法对 SCD 风险进行分层。这种创新的无创系统可在任何环境下轻松使用。该电子健康云系统使用了 203 人的数据进行评估,其中包括 SCD 高风险慢性心力衰竭 (CHF) 患者和年龄匹配的健康对照组。统计分析在两个持续时间不同的时间窗口中进行;第一个时间窗口持续时间为 20 分钟,第二个时间窗口为 10 分钟。利用现代机器学习方法,对第一个窗口和第二个窗口(半小时)进行了分类,以区分 CHF 患者和健康对照组。结果表明,即使是 10 分钟时间窗内采集的样本,也能很好地区分两组。在将这一新型电子健康云系统用于日常临床实践之前,还需要进行更大规模的研究,以进一步验证其有效性。
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引用次数: 0
EMI challenges in modern power electronic-based converters: recent advances and mitigation techniques 现代电力电子转换器中的电磁干扰挑战:最新进展和缓解技术
Pub Date : 2023-11-09 DOI: 10.3389/felec.2023.1274258
Liang Yuan, Jian Zhang, Zheng Liang, Mingxin Hu, Genhua Chen, Wei Lu
The utilization of power electronic-based converters is gaining momentum across a wide spectrum of industries. However, modern power electronic converters operate at higher frequencies compared to conventional power electronic converters, which can lead to higher rates of change in voltage and current during phase switching, and thus potentially produce more severe conducted and radiated electromagnetic interference (EMI). Their electromagnetic compatibility (EMC) has become a critical research topic, and EMI in high-frequency power electronic-based converters is more complex than that in conventional converters. This review presents a comprehensive survey of recent advancements, EMI design, and analysis of modern power electronic-based converters, focusing on the sources and mechanisms of both conducted and radiated EMI, and mitigating techniques. This review also covers the impact of topology optimization, control strategy design, and packaging design on EMC performance. Addressing emerging EMI issues in modern power electronic device-based converters is essential for ensuring safe and reliable operations. Through strategic design optimization and the implementation of EMI mitigation strategies, modern converters can seamlessly be integrated into diverse applications, offering improved EMI performance as a hallmark of their versatility.
基于电力电子的变换器的利用正在广泛的行业中获得动力。然而,与传统的电力电子变换器相比,现代电力电子变换器在更高的频率下工作,这可能导致在相位切换期间电压和电流的更高变化率,从而可能产生更严重的传导和辐射电磁干扰(EMI)。它们的电磁兼容性(EMC)已成为一个重要的研究课题,而高频电力电子变换器中的电磁干扰比传统变换器中的电磁干扰更为复杂。本文综述了最新进展、电磁干扰设计和现代电力电子变换器的分析,重点介绍了传导和辐射电磁干扰的来源和机制,以及缓解技术。本文还介绍了拓扑优化、控制策略设计和封装设计对EMC性能的影响。解决基于现代电力电子器件的变换器中新出现的电磁干扰问题对于确保安全可靠地运行至关重要。通过战略性设计优化和EMI缓解策略的实施,现代转换器可以无缝集成到各种应用中,提供改进的EMI性能作为其多功能性的标志。
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引用次数: 0
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Frontiers in electronics
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