调节神经植入物弹性调节周围神经再生

Q1 Engineering Smart Materials in Medicine Pub Date : 2023-01-01 DOI:10.1016/j.smaim.2022.11.004
Yan Kong , Jiawei Xu , Wenchao Guan , Shaolan Sun , Yumin Yang , Guicai Li
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引用次数: 4

摘要

大量研究深入研究了组织工程神经移植物(tissue-engineered neural graft, TENG)的生物学和化学特性对周围神经再生的影响,同时移植物的物理特性对损伤神经的再生也有显著的影响。其中,TENG的弹性特性对周围神经再生中神经细胞的粘附、增殖、迁移和生物功能有显著影响。本文综述了周围神经系统弹性生物材料的最新研究进展,包括弹性生物材料的分类、制备方法以及弹性对神经细胞生长行为的影响等。此外,还简要描述了弹性衬底对细胞本身弹性的影响。最后,我们分析和讨论了弹性基质影响神经细胞行为的潜在机制。
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Tailoring the elasticity of nerve implants for regulating peripheral nerve regeneration

Numerous studies have conducted in-depth research on the biological and chemical properties of tissue-engineered neural graft (TENG) on peripheral nerve regeneration, while the physical properties of the graft also display a significant impact on the regeneration of the injured nerve. Among them, the elasticity properties of TENG show a significant impact on the adhesion, proliferation, migration and bio-functionality of nerve cells in peripheral nerve regeneration. This review summarizes the latest research progress on elastic biomaterials for peripheral nervous system (PNS), including categories of elastic biomaterials, preparation methods and the effect of elasticity on the growth behavior of nerve cells, etc. In addition, the effect of the elastic substrate on the elasticity of the cell itself is also briefly described. Finally, we analyze and discuss the underlying mechanism by which elastic substrate affects nerve cell behavior.

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来源期刊
Smart Materials in Medicine
Smart Materials in Medicine Engineering-Biomedical Engineering
CiteScore
14.00
自引率
0.00%
发文量
41
审稿时长
48 days
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