甘多灵联合二巯基磺酸钠治疗中国神经性威尔逊氏病的疗效和安全性评价

IF 2 4区 医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE Journal of Traditional Chinese Medicine Pub Date : 2018-10-01 DOI:10.1016/S0254-6272(18)30919-1
Zhang Jing , Xie Daojun , Guo Yanbing , Li Yajun , Li Liangyong , Han Hui , Zhang Juan , Chen Huaizhen , Wang Meixia
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引用次数: 6

摘要

目的评价甘多灵联合二巯基磺酸钠(DMPS)治疗神经性威尔逊病(WD)的疗效和安全性。方法回顾性分析125例合并神经系统综合征的WD患者的临床资料,这些患者分别使用甘多灵联合DMPS钠或单独使用DMPS钠。所有患者在病程中均有神经功能恶化史。结果92.30%(60例)WD患者经联合治疗后神经系统状况改善或稳定,GAS评分显著提高。同时WBC和PLT计数稳定,肝功能和肾功能改善或保持稳定。联合用药对24小时尿铜排泄也有明显促进作用。其中,仅30.76%的WD患者出现轻度不良反应,其中神经系统恶化5例(7.69%),肝脏恶化1例(1.89%),发生率低于仅接受DMPS治疗的对照组。结论肝毒灵联合DMPS治疗伴有神经系统症状的WD患者的安全性和有效性优于单用DMPS。
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Evaluation of efficacy and safety of gandouling plus sodium dimercaptosulphonate in treatment of patients with neurological Wilson's disease from China

OBJECTIVE

To evaluate the efficacy and safety of gandouling plus sodium dimercaptosulphonate (DMPS) on neurological Wilson's disease (WD) in patients.

METHODS

We retrospectively evaluated the clinical records of 125 WD patients with neurological syndromes who were treated with gandouling plus sodium DMPS or DMPS used alone. All patients had a history of neurological deterioration during their diseases courses. The clinical efficacies, adverse reactions, and results of the various hematological and biochemical investigations were recorded for statistical analysis.

RESULTS

92.30% (60 patients) of the WD patients treated with the combined therapy experienced an improved or stable neurological condition paralleled by a significantly improved GAS score. Meanwhile, the WBC and PLT counts stabilized, liver function and renal function were improved or remained stable. The combined therapy also obviously promoted the 24-h urinary copper excretion. In particular, only 30.76% of the WD patients experienced mild adverse reactions, including neurological deterioration in 5 patients (7.69%), hepatic worsening in 1 subject (1.89%), which was less frequently than those in the control group treated with DMPS only.

CONCLUSION

Our findings indicate that the safety and efficacy of gandou-ling plus DMPS is superior to those of DMPS used alone in the WD patients with neurological symptoms.

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来源期刊
Journal of Traditional Chinese Medicine
Journal of Traditional Chinese Medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-
CiteScore
2.40
自引率
3.80%
发文量
32269
审稿时长
2 months
期刊介绍: Journal of Traditional Chinese Medicine(JTCM) is devoted to clinical and theortical research on the use of acupuncture and Oriental medicine. The main columns include Clinical Observations, Basic Investigations, Reviews, Questions and Answers, an Expert''s Forum, and Discussions of Clinical Cases. Its key topics include acupuncture and electro-acupuncture, herbal medicine, homeopathy, masseotherapy, mind-body therapies, palliative care, and other CAM therapies.
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