儿童中枢神经系统原发性黑色素细胞瘤:影像学特征与病理相关性

Q4 Medicine Neurographics Pub Date : 2022-04-01 DOI:10.3174/ng.2100033
M. Quinn, J. Aw-Zoretic, N. Wadhwani, A. Jaju
{"title":"儿童中枢神经系统原发性黑色素细胞瘤:影像学特征与病理相关性","authors":"M. Quinn, J. Aw-Zoretic, N. Wadhwani, A. Jaju","doi":"10.3174/ng.2100033","DOIUrl":null,"url":null,"abstract":"Primary melanocytic tumors of the central nervous system are rare neoplasms arising from proliferation of multipotent melanin-containing neural crest cells found in the leptomeninges. This review describes the imaging appearance of the entire spectrum of primary melanocytic tumors of\n the brain and spine in the pediatric population, in correlation with histopathology, clinical features, and prognosis, using sample cases from our institution. These tumors are subclassified by the World Health Organization on the basis of disease distribution and pathologic aggressiveness\n into the following 4 subtypes: meningeal melanocytoma, meningeal melanoma, meningeal melanocytosis, and meningeal melanomatosis. They can occur in any age group, though the diffuse form of the disease is more prevalent in children and has an association with giant cutaneous melanocytic\n nevi. Imaging is characterized by hyperattenuation on CT and intrinsic T1 hyperintensity on MR imaging from the presence of melanin and/or hemorrhage. The focal forms usually manifest as dural-based hemorrhagic masses, and the diffuse forms demonstrate dural thickening and enhancement, with\n or without hydrocephalus. There is a predilection for the medial temporal lobes, posterior fossa, and upper cervical spine. The prognosis is often poor, with a high incidence of malignant transformation of benign disease.Learning Objective: To describe the imaging appearance of the spectrum\n of primary melanocytic tumors of the brain and spine in the pediatric population and to review the histopathology, clinical, and prognostic data available","PeriodicalId":36193,"journal":{"name":"Neurographics","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Primary Melanocytic Tumors of the Central Nervous System in Children: Imaging Features with Pathologic Correlation\",\"authors\":\"M. Quinn, J. Aw-Zoretic, N. Wadhwani, A. Jaju\",\"doi\":\"10.3174/ng.2100033\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Primary melanocytic tumors of the central nervous system are rare neoplasms arising from proliferation of multipotent melanin-containing neural crest cells found in the leptomeninges. This review describes the imaging appearance of the entire spectrum of primary melanocytic tumors of\\n the brain and spine in the pediatric population, in correlation with histopathology, clinical features, and prognosis, using sample cases from our institution. These tumors are subclassified by the World Health Organization on the basis of disease distribution and pathologic aggressiveness\\n into the following 4 subtypes: meningeal melanocytoma, meningeal melanoma, meningeal melanocytosis, and meningeal melanomatosis. They can occur in any age group, though the diffuse form of the disease is more prevalent in children and has an association with giant cutaneous melanocytic\\n nevi. Imaging is characterized by hyperattenuation on CT and intrinsic T1 hyperintensity on MR imaging from the presence of melanin and/or hemorrhage. The focal forms usually manifest as dural-based hemorrhagic masses, and the diffuse forms demonstrate dural thickening and enhancement, with\\n or without hydrocephalus. There is a predilection for the medial temporal lobes, posterior fossa, and upper cervical spine. The prognosis is often poor, with a high incidence of malignant transformation of benign disease.Learning Objective: To describe the imaging appearance of the spectrum\\n of primary melanocytic tumors of the brain and spine in the pediatric population and to review the histopathology, clinical, and prognostic data available\",\"PeriodicalId\":36193,\"journal\":{\"name\":\"Neurographics\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Neurographics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3174/ng.2100033\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurographics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3174/ng.2100033","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0

摘要

中枢神经系统原发性黑色素细胞肿瘤是由软脑膜中发现的含有多能黑色素的神经嵴细胞增殖引起的罕见肿瘤。这篇综述使用我们机构的样本病例,描述了儿科人群中大脑和脊椎原发性黑色素细胞肿瘤的全谱影像学表现,与组织病理学、临床特征和预后的相关性。世界卫生组织根据疾病分布和病理侵袭性将这些肿瘤分为以下4种亚型:脑膜黑色素细胞瘤、脑膜黑色素瘤、脑膜黑素瘤和脑膜黑色素增多症。它们可以发生在任何年龄组,尽管这种疾病的弥漫型在儿童中更常见,并与巨大的皮肤黑色素细胞痣有关。影像学的特征是CT上的过度注意和由于存在黑色素和/或出血而在MR成像上的固有T1高信号。局灶型通常表现为硬膜基出血性肿块,弥漫型表现为硬膜增厚和强化,伴有或不伴有脑积水。颞叶内侧、后颅窝和上颈椎是一种偏好。预后往往较差,良性疾病恶变发生率高。学习目的:描述儿童脑和脊柱原发性黑色素细胞肿瘤的影像学表现,并回顾现有的组织病理学、临床和预后数据
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Primary Melanocytic Tumors of the Central Nervous System in Children: Imaging Features with Pathologic Correlation
Primary melanocytic tumors of the central nervous system are rare neoplasms arising from proliferation of multipotent melanin-containing neural crest cells found in the leptomeninges. This review describes the imaging appearance of the entire spectrum of primary melanocytic tumors of the brain and spine in the pediatric population, in correlation with histopathology, clinical features, and prognosis, using sample cases from our institution. These tumors are subclassified by the World Health Organization on the basis of disease distribution and pathologic aggressiveness into the following 4 subtypes: meningeal melanocytoma, meningeal melanoma, meningeal melanocytosis, and meningeal melanomatosis. They can occur in any age group, though the diffuse form of the disease is more prevalent in children and has an association with giant cutaneous melanocytic nevi. Imaging is characterized by hyperattenuation on CT and intrinsic T1 hyperintensity on MR imaging from the presence of melanin and/or hemorrhage. The focal forms usually manifest as dural-based hemorrhagic masses, and the diffuse forms demonstrate dural thickening and enhancement, with or without hydrocephalus. There is a predilection for the medial temporal lobes, posterior fossa, and upper cervical spine. The prognosis is often poor, with a high incidence of malignant transformation of benign disease.Learning Objective: To describe the imaging appearance of the spectrum of primary melanocytic tumors of the brain and spine in the pediatric population and to review the histopathology, clinical, and prognostic data available
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Neurographics
Neurographics Medicine-Radiology, Nuclear Medicine and Imaging
CiteScore
0.20
自引率
0.00%
发文量
12
期刊最新文献
Toshio Moritani, MD, PhD Invasive Fungal Infection Mimicking Infarctions in a Child with Acute Lymphoblastic Leukemia Dynamic Fluoroscopic Myelography in the Evaluation of Spinal Dorsal Arachnoid Web Tumor Response Metrics in Neuro-Oncology: A Review Perfusion MRI Techniques: Beyond DSC
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1