Investigation of Hepatitis A virus outbreak in Aligarh and its peripheral areas, Uttar Pradesh, India

The onset of hepatitis A is often sudden and characteristic symptoms are followed, within a few days to a week, by yellowish discoloration of eyes, fever, nausea, vomiting dark urine and jaundice. Serum alanine and aspartate levels of aminotransferase normally all rise rapidly during the prodromal cycle, reach peak rates and then decrease by 75 per cent per week. Serum total bilirubin concentrations reach peak levels later and decline slowly than serum aminotransferases. The period of jaundice persists for <3 weeks in 80% of cases. Nearly all adult patients with clinically evident disease undergo complete clinical restoration with a 5‐month.4