单一治疗与综合治疗对癫痫发作患儿血清25-羟基维生素D水平的影响

IF 0.3 Q4 PEDIATRICS Journal of Child Science Pub Date : 2021-01-01 DOI:10.1055/s-0041-1740467
Nazeem Fathima A., Radha Kumar, D. V., D. Chaudhary
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引用次数: 0

摘要

癫痫患者血清25-羟基维生素D (25(OH)D)抗癫痫药物(aed)与骨骼健康之间的关系已经被认识了30多年。几项研究表明,服用抗癫痫药物以及血清25(OH)D水平低的患者骨质流失的风险增加。与单一治疗的患者相比,接受多种治疗的AED患者发生药物不良反应的风险更高。本研究评估了接受AED治疗的儿童血清25(OH)D水平,并比较了接受单一治疗和多种治疗的儿童。这是一项在三级医院进行的前瞻性横断面研究,研究对象是接受aed治疗超过6个月的癫痫发作儿童。参与者被分为三组:25名儿童接受单一治疗,25名儿童接受综合治疗,25名儿童接受健康对照。检测所有患儿血清25(OH)D水平并进行分析。52%的儿童血清25(OH)D水平正常,43.3%的儿童血清水平不足,6.7%的儿童血清水平不足。40%接受单一治疗的儿童维生素D水平不足,52%接受综合治疗的儿童维生素D水平不足。单一治疗组维生素D缺乏率为4%,综合治疗组为16%,差异有统计学意义(p值为0.047)。与正常对照组相比,接受体外除颤器治疗的儿童维生素D缺乏症更高。综合治疗组儿童维生素D缺乏症和不足发生率较高。我们的研究强调了在接受AED治疗的儿童中监测维生素D水平以检测维生素D水平异常的重要性。
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A Comparative Study of Serum 25-Hydroxy Vitamin D Levels in Children with Seizures Receiving Monotherapy and Polytherapy
Abstract The association between serum 25-hydroxy vitamin D (25(OH)D) antiepileptic drugs (AEDs) and bone health in individuals with epilepsy has been recognized for more than 30 years. Several studies indicate an increased risk for bone loss in patients on antiepileptic medication as well as low levels of serum 25(OH)D. Patients on polytherapy AED are at a higher risk of adverse drug effects compared with those on monotherapy. The present study assessed serum 25(OH)D levels in children receiving AED and compares those children receiving monotherapy versus polytherapy. This is a prospective cross-sectional study conducted in a tertiary care hospital setting on children with seizures receiving AEDs for period of more than 6 months. Participants were enrolled in three groups: 25 children on monotherapy, 25 children on polytherapy, and 25 healthy controls. Serum 25(OH)D level was performed for all children and analyzed. Serum 25(OH)D levels were normal in 52%, insufficient levels in 43.3%, and deficient in 6.7% of children. Vitamin D level was insufficient in 40% of children receiving monotherapy and 52% receiving polytherapy AED. Vitamin D deficiency was present in 4% in monotherapy group and 16% in polytherapy group which was statistically significant (p-value 0.047). Vitamin D deficiency was higher in children receiving AED compared with normal controls. Vitamin D deficiency and insufficiency were higher in children on polytherapy. Our study emphasized the importance of monitoring vitamin D levels in children receiving AED to detect abnormalities in vitamin D levels.
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