荧光团j聚集体与纳米间隔组装在介孔纳米颗粒上增强光声成像

IF 7.1 1区医学 Q1 ENGINEERING, BIOMEDICAL Photoacoustics Pub Date : 2023-10-01 DOI:10.1016/j.pacs.2023.100552

Wujun Xu, Jarkko Leskinen, Teemu Sahlström, Emilia Happonen, Tanja Tarvainen, Vesa-Pekka Lehto

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引用次数: 0

摘要

许多荧光团，如吲哚菁绿（ICG），具有较差的光稳定性和较低的光热效率，阻碍了它们在光声（PA）层析成像中的广泛应用。在本研究中，使用超分子组装方法开发了ICG和多孔硅（PSi）的杂化纳米颗粒（Hy-NPs），作为PA断层扫描的新型造影剂。ICG组装在PSi NP上，在30分钟内形成J聚集体。Hy-NP呈现出红移吸收，改善了光热稳定性，并增强了PA性能。此外，1-十二烯（DOC）作为“纳米空间”组装到NP中，这增强了非辐射衰变，增加了热释放。与Hy NP相比，在Hy NP中添加DOC（DOC-Hi）可使PA信号增加83%。最后，在组织体模中1.5 cm深度的PA断层扫描中可以检测到DOC Hy，尽管其浓度低至6.25µg/mL，这表明了深层组织PA成像的潜力。

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Assembly of ﬂuorophore J-aggregates with nanospacer onto mesoporous nanoparticles for enhanced photoacoustic imaging

Many ﬂuorophores, such as indocyanine green (ICG), have poor photostability and low photothermal efficiency hindering their wide application in photoacoustic (PA) tomography. In the present study, a supramolecular assembly approach was used to develop the hybrid nanoparticles (Hy NPs) of ICG and porous silicon (PSi) as a novel contrast agent for PA tomography. ICG was assembled on the PSi NPs to form J-aggregates within 30 min. The Hy NPs presented a red-shifted absorption, improved photothermal stability, and enhanced PA performance. Furthermore, 1-dodecene (DOC) was assembled into the NPs as a ‘nanospacer’, which enhanced non-radiative decay for increased thermal release. Compared to the Hy NPs, adding DOC into the Hy NPs (DOC-Hy) increased the PA signal by 83%. Finally, the DOC-Hy was detectable in PA tomography at 1.5 cm depth in tissue phantom even though its concentration was as low as 6.25 µg/mL, indicating the potential for deep tissue PA imaging.

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来源期刊

Photoacoustics Physics and Astronomy-Atomic and Molecular Physics, and Optics

CiteScore

11.40

自引率

16.50%

发文量

审稿时长

53 days

期刊介绍： The open access Photoacoustics journal (PACS) aims to publish original research and review contributions in the field of photoacoustics-optoacoustics-thermoacoustics. This field utilizes acoustical and ultrasonic phenomena excited by electromagnetic radiation for the detection, visualization, and characterization of various materials and biological tissues, including living organisms. Recent advancements in laser technologies, ultrasound detection approaches, inverse theory, and fast reconstruction algorithms have greatly supported the rapid progress in this field. The unique contrast provided by molecular absorption in photoacoustic-optoacoustic-thermoacoustic methods has allowed for addressing unmet biological and medical needs such as pre-clinical research, clinical imaging of vasculature, tissue and disease physiology, drug efficacy, surgery guidance, and therapy monitoring. Applications of this field encompass a wide range of medical imaging and sensing applications, including cancer, vascular diseases, brain neurophysiology, ophthalmology, and diabetes. Moreover, photoacoustics-optoacoustics-thermoacoustics is a multidisciplinary field, with contributions from chemistry and nanotechnology, where novel materials such as biodegradable nanoparticles, organic dyes, targeted agents, theranostic probes, and genetically expressed markers are being actively developed. These advanced materials have significantly improved the signal-to-noise ratio and tissue contrast in photoacoustic methods.