一种简单有效的偶氮[4,3-b]吲哚的构建方法

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2022-12-30 DOI:10.20450/mjcce.2022.2471

N. Uludağ

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引用次数: 0

摘要

开发了一种新的合成方法，通过四氟-1,4-苯醌（TFB）介导的C-2位带有酰胺侧链的四氢咔唑衍生物的环化反应制备具有生物学意义的偶氮并[4，3-b]吲哚。该策略首次基于四氢咔唑C-2位的不同方法，用于合成甲酰偶氮[4，3-b]吲哚。该方案的显著特征包括其操作简单和高反应产率。此外，使用光谱方法（1H NMR、13C NMR、FT-IR）确认了所有目前合成的化合物的结构。

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A simple and efficient method for constructing azocino[4,3-b]indole

A new synthetic procedure has been developed to prepare the biologically important azocino[4,3-b]indole via the tetrafluoro-1,4-benzoquinone (TFB)-mediated cyclization of a tetrahydrocarbazole derivative bearing an amide side chain at the C-2 position. For the first time, this strategy is based on a different method for the C-2 position of the tetrahydrocarbazole for the synthesis of methanoazocino[4,3-b]indole. The notable features of this protocol include its operational simplicity and high reaction yields. Furthermore, the structures of all the presently synthesized compounds were confirmed using spectroscopic methods (1H NMR, 13C NMR, FT-IR).

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.