Pub Date : 2023-12-25DOI: 10.20450/mjcce.2023.2775
Nevena Jaćimović, M. Djošić, A. Jankovic, Svetlana Grujić, Ivana Matić Bujagić, J. Stojanović, M. Vukašinović-Sekulić, Vesna Kojić, V. Mišković‐Stanković
Biocomposite hydroxyapatite/poly(vinyl alcohol)/chitosan/gentamicin coatings were fabricated on titanium by electrophoretic deposition process (EPD) from an aqueous suspension using the constant voltage method. Characterization of the deposited coatings was performed by scanning electron microscopy with field emission (FE–SEM), Fourier transform infrared spectroscopy (FT–IR) and X-ray diffraction (XRD) after immersion in simulated body fluid (SBF) at 37 °C. The concentration of the released gentamicin was determined using a high-performance liquid chromatography (HPLC) coupled with a mass spectrometer (MS). The release profile confirmed an initial “burst-release effect” with ~ 30% of gentamicin released in the first 48 h, which could be of assistance in the prevention of biofilm formation. Antibacterial activity was proven by the agar diffusion method on Staphylococcus aureus TL and Escherichia coli ATCC 25922 bacterial strains. Cytotoxicity was tested by the dye exclusion test (DET) on MRC-5 and L929 fibroblast cell lines, with both coatings expressing nontoxicity. The results showed the high applicability potential of a poly(vinyl alcohol)-based biocomposite coating for medical purposes.
{"title":"Single-step, electrophoretically deposited hydroxyapatite/poly(vinyl alcohol)/chitosan/gentamicin coating for biomedical applications","authors":"Nevena Jaćimović, M. Djošić, A. Jankovic, Svetlana Grujić, Ivana Matić Bujagić, J. Stojanović, M. Vukašinović-Sekulić, Vesna Kojić, V. Mišković‐Stanković","doi":"10.20450/mjcce.2023.2775","DOIUrl":"https://doi.org/10.20450/mjcce.2023.2775","url":null,"abstract":"Biocomposite hydroxyapatite/poly(vinyl alcohol)/chitosan/gentamicin coatings were fabricated on titanium by electrophoretic deposition process (EPD) from an aqueous suspension using the constant voltage method. Characterization of the deposited coatings was performed by scanning electron microscopy with field emission (FE–SEM), Fourier transform infrared spectroscopy (FT–IR) and X-ray diffraction (XRD) after immersion in simulated body fluid (SBF) at 37 °C. The concentration of the released gentamicin was determined using a high-performance liquid chromatography (HPLC) coupled with a mass spectrometer (MS). The release profile confirmed an initial “burst-release effect” with ~ 30% of gentamicin released in the first 48 h, which could be of assistance in the prevention of biofilm formation. Antibacterial activity was proven by the agar diffusion method on Staphylococcus aureus TL and Escherichia coli ATCC 25922 bacterial strains. Cytotoxicity was tested by the dye exclusion test (DET) on MRC-5 and L929 fibroblast cell lines, with both coatings expressing nontoxicity. The results showed the high applicability potential of a poly(vinyl alcohol)-based biocomposite coating for medical purposes.","PeriodicalId":18088,"journal":{"name":"Macedonian Journal of Chemistry and Chemical Engineering","volume":"47 S1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2023-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139158602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-25DOI: 10.20450/mjcce.2023.2635
Stanislav Kurajica, Marija Vuković Domanovac, K. Mužina
Silver nanowires were prepared by the polyol process with ethylene glycol as a solvent and reducing agent, silver nitrate as a silver source, polyvinylpyrrolidone as a growth-directing agent, stabilizer and agglomeration prevention agent, and copper chloride as a growth control agent. The product was characterized by UV–Vis spectroscopy, scanning electron microscopy, and X-ray diffraction. The biocidal activity of silver nanowires was investigated using the disc diffusion method on the bacteria Bacillus subtilis and Pseudomonas aeruginosa and the fungi Aspergillus niger and Candida albicans. X-ray diffraction and scanning electron microscopy showed that, in addition to silver nanowires, the product also contains quasi-spherical silver nanoparticles and some silver chloride. Based on the results of UV–Vis spectroscopy and scanning electron microscopy, it was estimated that the diameter of the nanowires is 200–300 nm. Nanowires have shown weak bactericidal and good fungicidal activity. Silver nanowires showed particularly good activity in inhibiting the growth of Candida albicans.
以乙二醇为溶剂和还原剂，硝酸银为银源，聚乙烯吡咯烷酮为生长引导剂、稳定剂和防团聚剂，氯化铜为生长控制剂，采用多元醇法制备了银纳米线。紫外可见光谱、扫描电子显微镜和 X 射线衍射对产品进行了表征。采用圆盘扩散法研究了银纳米线对细菌枯草芽孢杆菌和绿脓杆菌以及真菌黑曲霉和白色念珠菌的杀菌活性。X 射线衍射和扫描电子显微镜显示，除纳米银线外，该产品还含有准球形纳米银颗粒和一些氯化银。根据紫外可见光谱和扫描电子显微镜的结果，估计纳米线的直径为 200-300 纳米。纳米线具有较弱的杀菌活性和较好的杀真菌活性。银纳米线在抑制白色念珠菌的生长方面表现出特别好的活性。
{"title":"Polyol synthesis of Ag nanowires and biocidal activity of the obtained product","authors":"Stanislav Kurajica, Marija Vuković Domanovac, K. Mužina","doi":"10.20450/mjcce.2023.2635","DOIUrl":"https://doi.org/10.20450/mjcce.2023.2635","url":null,"abstract":"Silver nanowires were prepared by the polyol process with ethylene glycol as a solvent and reducing agent, silver nitrate as a silver source, polyvinylpyrrolidone as a growth-directing agent, stabilizer and agglomeration prevention agent, and copper chloride as a growth control agent. The product was characterized by UV–Vis spectroscopy, scanning electron microscopy, and X-ray diffraction. The biocidal activity of silver nanowires was investigated using the disc diffusion method on the bacteria Bacillus subtilis and Pseudomonas aeruginosa and the fungi Aspergillus niger and Candida albicans. X-ray diffraction and scanning electron microscopy showed that, in addition to silver nanowires, the product also contains quasi-spherical silver nanoparticles and some silver chloride. Based on the results of UV–Vis spectroscopy and scanning electron microscopy, it was estimated that the diameter of the nanowires is 200–300 nm. Nanowires have shown weak bactericidal and good fungicidal activity. Silver nanowires showed particularly good activity in inhibiting the growth of Candida albicans.","PeriodicalId":18088,"journal":{"name":"Macedonian Journal of Chemistry and Chemical Engineering","volume":"44 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2023-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139159004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-25DOI: 10.20450/mjcce.2023.2698
Leposava Pavun, Danijela Stojanović, A. Ivanovska, Jelena M. Lađarević, Marina Milenković, S. Uskoković-Marković
Green, black, rooibos, and hibiscus tea (GT, BT, RT, and HT) aqueous extracts were prepared and characterized in terms of total flavonoids (TFC) and total phenolic (TPC) contents and antioxidant and antimicrobial activities. BT has the highest, while HT has the lowest TFC (1213 vs. 415 mg l–1), while the extracts’ TPCs (2283 – 7251 mg l–1) decreased in the following order: BT > GT > RT > HT. Their antioxidant activities of 78.1 – 93.1% and 97.8 – 100% were determined according to DPPH and ABTS methods, respectively. BT and especially GT aqueous extracts possessed mild effects against several microorganisms. All examined extracts have an affinity for dyeing wool, cellulose acetate, polyamide, and cotton, which is proven by the color strength values of 1.65–19.12. Wool, polyacrylonitrile, polyester, polyamide, cotton, and cellulose acetate functionalized with GT aqueous extract inhibited the growth of S. aureus and E. coli, while polyacrylonitrile and cotton also inhibited the growth of E. faecalis, and C. albicans, respectively. Wide inhibition zones for S. aureus were observed for fabrics functionalized with BT aqueous extract. Generally, the investigated fabrics showed very high (81.60 – 100%) ABTS radical scavenging ability independent of the extract used. TPCs have good linear correlations with the antioxidant activities of wool and polyacrylonitrile determined by the DPPH method. Fabrics with different chemical compositions dyed and/or functionalized with GT or BT aqueous extracts can be used to produce high-value-added medical textiles with therapeutic, prophylactic, and protective functions. They can find potential applications in wound treatment, especially in skin wounds that are susceptible to infection with S. aureus. Moreover, wool and cotton functionalized with GT or BT aqueous extract can also be considered for use in disposable medical textiles like bandages and gauze used in the wound-healing process.
{"title":"Characterization of tea water extracts and their utilization for dyeing and functionalization of fabrics of different chemical compositions","authors":"Leposava Pavun, Danijela Stojanović, A. Ivanovska, Jelena M. Lađarević, Marina Milenković, S. Uskoković-Marković","doi":"10.20450/mjcce.2023.2698","DOIUrl":"https://doi.org/10.20450/mjcce.2023.2698","url":null,"abstract":"Green, black, rooibos, and hibiscus tea (GT, BT, RT, and HT) aqueous extracts were prepared and characterized in terms of total flavonoids (TFC) and total phenolic (TPC) contents and antioxidant and antimicrobial activities. BT has the highest, while HT has the lowest TFC (1213 vs. 415 mg l–1), while the extracts’ TPCs (2283 – 7251 mg l–1) decreased in the following order: BT > GT > RT > HT. Their antioxidant activities of 78.1 – 93.1% and 97.8 – 100% were determined according to DPPH and ABTS methods, respectively. BT and especially GT aqueous extracts possessed mild effects against several microorganisms. All examined extracts have an affinity for dyeing wool, cellulose acetate, polyamide, and cotton, which is proven by the color strength values of 1.65–19.12. Wool, polyacrylonitrile, polyester, polyamide, cotton, and cellulose acetate functionalized with GT aqueous extract inhibited the growth of S. aureus and E. coli, while polyacrylonitrile and cotton also inhibited the growth of E. faecalis, and C. albicans, respectively. Wide inhibition zones for S. aureus were observed for fabrics functionalized with BT aqueous extract. Generally, the investigated fabrics showed very high (81.60 – 100%) ABTS radical scavenging ability independent of the extract used. TPCs have good linear correlations with the antioxidant activities of wool and polyacrylonitrile determined by the DPPH method. Fabrics with different chemical compositions dyed and/or functionalized with GT or BT aqueous extracts can be used to produce high-value-added medical textiles with therapeutic, prophylactic, and protective functions. They can find potential applications in wound treatment, especially in skin wounds that are susceptible to infection with S. aureus. Moreover, wool and cotton functionalized with GT or BT aqueous extract can also be considered for use in disposable medical textiles like bandages and gauze used in the wound-healing process.","PeriodicalId":18088,"journal":{"name":"Macedonian Journal of Chemistry and Chemical Engineering","volume":"37 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2023-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139159779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-24DOI: 10.20450/mjcce.2023.2762
D. Andjelković, Milica Branković
This research was focused on the performance evaluation of a simple sample preparation involving acetonitrile extraction followed by liquid chromatography/mass spectrometry (LC/MS) analysis. Simplified method validation parameters, along with several other features, were compared to those of the citrate QuEChERS for 19 pesticides analyzed in four representative fruits and vegetables. The results showed comparable performances of the two methods for 5 of the 6 investigated validation parameters. The simplified method had better performance regarding the selectivity, since three analytes experienced a selectivity issue in one of four QuEChERS-treated matrices. Overall, results lead to an assumption that acetonitrile extraction could be reasonably implemented in certain cases of pesticide analysis, as an efficient and economical alternative to the official method. Since the research provides an insight into acetonitrile extraction capabilities in the domain of pesticide analysis in complex matrices, scientists, researchers or analytical practitioners can determine which method is most beneficial for a particular analysis.
{"title":"One-step extraction versus QuEChERS for pesticide analysis in selected fruits and vegetables","authors":"D. Andjelković, Milica Branković","doi":"10.20450/mjcce.2023.2762","DOIUrl":"https://doi.org/10.20450/mjcce.2023.2762","url":null,"abstract":"This research was focused on the performance evaluation of a simple sample preparation involving acetonitrile extraction followed by liquid chromatography/mass spectrometry (LC/MS) analysis. Simplified method validation parameters, along with several other features, were compared to those of the citrate QuEChERS for 19 pesticides analyzed in four representative fruits and vegetables. The results showed comparable performances of the two methods for 5 of the 6 investigated validation parameters. The simplified method had better performance regarding the selectivity, since three analytes experienced a selectivity issue in one of four QuEChERS-treated matrices. Overall, results lead to an assumption that acetonitrile extraction could be reasonably implemented in certain cases of pesticide analysis, as an efficient and economical alternative to the official method. Since the research provides an insight into acetonitrile extraction capabilities in the domain of pesticide analysis in complex matrices, scientists, researchers or analytical practitioners can determine which method is most beneficial for a particular analysis.","PeriodicalId":18088,"journal":{"name":"Macedonian Journal of Chemistry and Chemical Engineering","volume":"397 2","pages":""},"PeriodicalIF":1.0,"publicationDate":"2023-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139160813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-24DOI: 10.20450/mjcce.2023.2750
Jean-Marie Bakhoum, O. Mbaye, J. Bakhoum, M. D. Gaye-Seye, Clément Trellu, Coly Atanasse, J. Aaron
In this work, we developed an UV-visible (UV-VIS) absorption spectrometric method for the quantification of sodium diclofenac in natural waters. Several UV-VIS absorption method parameters were optimized. The maximum absorption wavelength was comprised between 276 and 292 nm, depending on the solvent, with molar absorption coefficients greater than 104 L mol-1 cm-1. The linearity of the UV-VIS calibration curves extended over one to three orders of magnitude, with correlation coefficients (R2) very close to unity. The low relative standard deviation (RSD) values indicated a good reproducibility of the measurements. Analytical applications to natural waters yielded satisfactory results with average recovery rates between 94.7 and 99.1%.
{"title":"Diclofenac analysis in natural waters using UV-visible absorption spectrometric method","authors":"Jean-Marie Bakhoum, O. Mbaye, J. Bakhoum, M. D. Gaye-Seye, Clément Trellu, Coly Atanasse, J. Aaron","doi":"10.20450/mjcce.2023.2750","DOIUrl":"https://doi.org/10.20450/mjcce.2023.2750","url":null,"abstract":"In this work, we developed an UV-visible (UV-VIS) absorption spectrometric method for the quantification of sodium diclofenac in natural waters. Several UV-VIS absorption method parameters were optimized. The maximum absorption wavelength was comprised between 276 and 292 nm, depending on the solvent, with molar absorption coefficients greater than 104 L mol-1 cm-1. The linearity of the UV-VIS calibration curves extended over one to three orders of magnitude, with correlation coefficients (R2) very close to unity. The low relative standard deviation (RSD) values indicated a good reproducibility of the measurements. Analytical applications to natural waters yielded satisfactory results with average recovery rates between 94.7 and 99.1%.","PeriodicalId":18088,"journal":{"name":"Macedonian Journal of Chemistry and Chemical Engineering","volume":"248 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2023-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139161142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-24DOI: 10.20450/mjcce.2023.2683
Marija Tomić, Marijana Božinovska, Nataša Anevska-Stojanovska, Jelena Lazova, R. Petkovska, L. Anastasova, N. Nakov
A new eco-friendly RP-HPLC method for determining diazepam in coated tablets was developed and validated. The separation was achieved on a Lichrosper® 100 RP-18 (250 mm × 4 mm, 5 µm particle size) using the isocratic elution mode with a mobile phase composed of a mixture of water (H2O) and ethanol (EtOH) in a 40:60 (v/v %) ratio and a flow rate of 1.0 mL/min. The injection volume was 10 μL, and the detection wavelength was set at 254 nm. The column temperature was maintained at 35 ºC. The method was validated according to the ICH guideline, emphasizing selectivity/specificity, linearity, sensitivity, accuracy, precision, and robustness. The analytical method greenness score and Eco-scale approach were used for the method’s greenness assessment. The method was applied to determine the assay of diazepam in coated tablets and the uniformity of dosage units by content uniformity. Applying the method proposed in this study in the pharmaceutical industry is considered environmentally sustainable. It would bring benefits in terms of a safer working environment and reduction of toxic waste formation without compromising the reliability of the analytical results.
开发并验证了一种新型环保型 RP-HPLC 方法，用于测定包衣片剂中的地西泮。采用等度洗脱模式，以水（H2O）和乙醇（EtOH）的混合物为流动相，流速为1.0 mL/min，在Lichrosper® 100 RP-18（250 mm × 4 mm，粒径5 µm）上进行分离。进样量为 10 μL，检测波长为 254 nm。色谱柱温度保持在 35 ºC。该方法按照 ICH 指南进行了验证，强调了选择性/特异性、线性、灵敏度、准确度、精密度和稳健性。该方法的绿色性评估采用了分析方法绿色性评分和生态尺度法。应用该方法测定了包衣片中地西泮的含量，并通过含量均一性确定了剂量单位的均一性。在制药行业应用本研究提出的方法被认为是环境可持续的。它将带来更安全的工作环境和减少有毒废物的产生，同时又不影响分析结果的可靠性。
{"title":"Eco-friendly RP-HPLC method for determination of diazepam in coated tablet","authors":"Marija Tomić, Marijana Božinovska, Nataša Anevska-Stojanovska, Jelena Lazova, R. Petkovska, L. Anastasova, N. Nakov","doi":"10.20450/mjcce.2023.2683","DOIUrl":"https://doi.org/10.20450/mjcce.2023.2683","url":null,"abstract":"A new eco-friendly RP-HPLC method for determining diazepam in coated tablets was developed and validated. The separation was achieved on a Lichrosper® 100 RP-18 (250 mm × 4 mm, 5 µm particle size) using the isocratic elution mode with a mobile phase composed of a mixture of water (H2O) and ethanol (EtOH) in a 40:60 (v/v %) ratio and a flow rate of 1.0 mL/min. The injection volume was 10 μL, and the detection wavelength was set at 254 nm. The column temperature was maintained at 35 ºC. The method was validated according to the ICH guideline, emphasizing selectivity/specificity, linearity, sensitivity, accuracy, precision, and robustness. The analytical method greenness score and Eco-scale approach were used for the method’s greenness assessment. The method was applied to determine the assay of diazepam in coated tablets and the uniformity of dosage units by content uniformity. Applying the method proposed in this study in the pharmaceutical industry is considered environmentally sustainable. It would bring benefits in terms of a safer working environment and reduction of toxic waste formation without compromising the reliability of the analytical results.","PeriodicalId":18088,"journal":{"name":"Macedonian Journal of Chemistry and Chemical Engineering","volume":"2001 9","pages":""},"PeriodicalIF":1.0,"publicationDate":"2023-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139160331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-24DOI: 10.20450/mjcce.2023.2707
Ksenija Pavlović, Ljubica M Grbović, Milica Ž. Karadžić Banjac, Strahinja Z. Kovačević, A. Mandic, S. Podunavac-Kuzmanovic, Bojana R. Vasiljević
In this study, eco-friendly microwave-assisted esterification reactions of chenodeoxycholic acid with medium-chain diols (1,2-ethanediol, 1,4-butanediol, 1,6-hexanediol, 1,8-octanediol, and 1,10-decanediol) or tetraethylene glycol were accomplished. The synthesized bile acid esters were obtained with high yields (up to 81 %) and purity in a short reaction time (15 min). It is shown that the microwave technique is a suitable method for the preparation of chenodeoxycholic acid esters. In order to obtain detailed insight into the lipophilic behavior of the studied chenodeoxycholic acid esters, a comparative study of chromatographic behavior and lipophilicity was performed. Also, the present study deals with the estimation of pH – logD profiles in order to get an overview of the changes in lipophilicity related to the pH value changes. The obtained results indicate that studied compounds have logD values in the range acceptable for potential drug candidates. Chromatographic lipophilicity of synthesized chenodeoxycholic acid esters successfully correlate with in silico lipophilicity descriptors.
{"title":"Microwave synthesis of novel chenodeoxycholic acid esters and comparative study of chromatographic behavior and lipophilicity","authors":"Ksenija Pavlović, Ljubica M Grbović, Milica Ž. Karadžić Banjac, Strahinja Z. Kovačević, A. Mandic, S. Podunavac-Kuzmanovic, Bojana R. Vasiljević","doi":"10.20450/mjcce.2023.2707","DOIUrl":"https://doi.org/10.20450/mjcce.2023.2707","url":null,"abstract":"In this study, eco-friendly microwave-assisted esterification reactions of chenodeoxycholic acid with medium-chain diols (1,2-ethanediol, 1,4-butanediol, 1,6-hexanediol, 1,8-octanediol, and 1,10-decanediol) or tetraethylene glycol were accomplished. The synthesized bile acid esters were obtained with high yields (up to 81 %) and purity in a short reaction time (15 min). It is shown that the microwave technique is a suitable method for the preparation of chenodeoxycholic acid esters. In order to obtain detailed insight into the lipophilic behavior of the studied chenodeoxycholic acid esters, a comparative study of chromatographic behavior and lipophilicity was performed. Also, the present study deals with the estimation of pH – logD profiles in order to get an overview of the changes in lipophilicity related to the pH value changes. The obtained results indicate that studied compounds have logD values in the range acceptable for potential drug candidates. Chromatographic lipophilicity of synthesized chenodeoxycholic acid esters successfully correlate with in silico lipophilicity descriptors.","PeriodicalId":18088,"journal":{"name":"Macedonian Journal of Chemistry and Chemical Engineering","volume":"2009 18","pages":""},"PeriodicalIF":1.0,"publicationDate":"2023-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139160191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-24DOI: 10.20450/mjcce.2023.2786
R. Gulaboski, Sanja Lazarova, Pavlinka Kokoskarova, Elena Joveva
Since the last decade of the 20th century, many scientific disciplines have heavily relied on materials with nanometer dimensions. Nanomaterials are already integrated into numerous biomedical and pharmaceutical applications, including the delivery of active substances to specific targets within the body. This has been demonstrated by their contribution to the containment of the recent COVID-19 pandemic. Graphene, silver, gold, and other nanoparticles possess exceptional physical and chemical properties, including increased thermal stability, improved conductivity, and the capacity to host various organic substrates on their surface area. In the past 20 years, a significant field of nanoparticle synthesis has emerged, where eco-friendly reducing agents found in numerous plant species are used. This brief review focuses on the outstanding performance of metallic nanoparticles synthesized using "green methods" in designing voltammetric biosensors. The major goal of this short review is to highlight some of the latest electrochemical advances in exploring metallic nano-systems obtained via phytosynthesis from plant extracts, covering the most notable achievements in the design of amperometric and voltammetric biosensors.
{"title":"Voltammetric biosensors based on metallic nanoparticles synthesized from plant extracts: A short overview of recent achievements","authors":"R. Gulaboski, Sanja Lazarova, Pavlinka Kokoskarova, Elena Joveva","doi":"10.20450/mjcce.2023.2786","DOIUrl":"https://doi.org/10.20450/mjcce.2023.2786","url":null,"abstract":"Since the last decade of the 20th century, many scientific disciplines have heavily relied on materials with nanometer dimensions. Nanomaterials are already integrated into numerous biomedical and pharmaceutical applications, including the delivery of active substances to specific targets within the body. This has been demonstrated by their contribution to the containment of the recent COVID-19 pandemic. Graphene, silver, gold, and other nanoparticles possess exceptional physical and chemical properties, including increased thermal stability, improved conductivity, and the capacity to host various organic substrates on their surface area. In the past 20 years, a significant field of nanoparticle synthesis has emerged, where eco-friendly reducing agents found in numerous plant species are used. This brief review focuses on the outstanding performance of metallic nanoparticles synthesized using \"green methods\" in designing voltammetric biosensors. The major goal of this short review is to highlight some of the latest electrochemical advances in exploring metallic nano-systems obtained via phytosynthesis from plant extracts, covering the most notable achievements in the design of amperometric and voltammetric biosensors.","PeriodicalId":18088,"journal":{"name":"Macedonian Journal of Chemistry and Chemical Engineering","volume":"2001 17","pages":""},"PeriodicalIF":1.0,"publicationDate":"2023-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139160308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-24DOI: 10.20450/mjcce.2023.2776
Jelena Čović, Valentin Mirčeski, Aleksandra Zarubica, Aleksandar Bojić, Miloš Marinković, M. Ranđelović
The study of hydrogen peroxide reduction in an alkaline aqueous medium on a composite of palladium particles dispersed in an amorphous carbon matrix (Pd@AC) was performed. Scanning Electron Microscopy (SEM), Energy-dispersive X-ray spectroscopy (EDX), Fourier-transform infrared spectroscopy (FTIR), and X-ray Powder Diffraction (XRD) were used to examine morphology, composition, and crystalline structure. The crystalline structure and size of palladium were analyzed using XRD. The reduction of hydrogen peroxide was studied through cyclic and square-wave voltammetry in an alkaline solution in the absence and presence of dissolved oxygen. The overall electrocatalytic effect of Pd@AC toward hydrogen peroxide reduction strongly depends on the presence of oxygen and the hydrogen peroxide disproportionation reaction in the three-phase system of amorphous carbon, palladium particles, and electrolyte solution.
研究了过氧化氢在碱性水介质中对分散在无定形碳基质（Pd@AC）中的钯颗粒复合材料的还原作用。研究采用扫描电子显微镜（SEM）、能量色散 X 射线光谱（EDX）、傅立叶变换红外光谱（FTIR）和 X 射线粉末衍射（XRD）来检测形态、成分和晶体结构。利用 XRD 分析了钯的晶体结构和尺寸。在无溶解氧和有溶解氧的碱性溶液中，通过循环伏安法和方波伏安法研究了过氧化氢的还原。Pd@AC 对过氧化氢还原的整体电催化效果在很大程度上取决于氧气的存在以及无定形碳、钯颗粒和电解质溶液三相体系中过氧化氢的歧化反应。
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Pub Date : 2023-12-24DOI: 10.20450/mjcce.2023.2777
Valerija Madžgalj, Aleksandar Petrović, V. Tešević, B. Anđelković, Ivana Sofrenić
Krstač and Žižak are autochthonous grape varieties grown in Montenegro. Although international varieties are more popular, the autochthonous varieties are very important, especially for countries developing tourism. The fermentation aromas produced during alcoholic fermentation contribute significantly to wine quality. The effects of yeasts (Saccharomyces cerevisiae and Saccharomyces bayanus) and yeast nutrients (Fermaid E and Fermaid O) on aromatic compounds in wines were investigated. Using GC/FID-MS analysis, aroma compounds in Krstač and Žižak wines were characterized and quantified. Wines produced with the addition of yeast and yeast nutrients had mostly lower total alcohol content than wines obtained by spontaneous fermentation of Krstač and Žižak varieties. The results of this study showed that the concentration of compounds depends on the yeast strains. The yeast S. cerevisiae (ICV) provided a higher content of higher alcohols, while S. bayanus produced a higher concentration of esters and (medium chain) fatty acids. Total ester content ranged from 3.34 to 11.97 mg/l for Krstač wines and 8.51 to 13.68 mg/l for Žižak wines. Among all wines, Krstač and Žižak wines produced with S. bayanus and Fermaid E addition had the highest concentration of total esters. The yeast nutrients Fermaid E and O emphasized different characteristics of the yeasts. They had a statistically significant effect on the content of ethyl and acetate esters. The highest overall scores were obtained for ICVE and BayE Krstač wines (18.1 out of 20 points) and Žižak ICVE wine (18.2 out of 20 points).
Krstač 和 Žižak 是黑山种植的本土葡萄品种。虽然国际葡萄品种更受欢迎，但本土葡萄品种也非常重要，尤其是对发展旅游业的国家而言。酒精发酵过程中产生的发酵香气对葡萄酒的品质有很大影响。研究了酵母（酿酒酵母和酿酒酵母）和酵母营养素（费米德 E 和费米德 O）对葡萄酒芳香化合物的影响。通过 GC/FID-MS 分析，对 Krstač 和 Žižak 葡萄酒中的芳香化合物进行了定性和定量分析。与 Krstač 和 Žižak 品种自发发酵酿造的葡萄酒相比，添加酵母和酵母营养素酿造的葡萄酒总酒精含量更低。研究结果表明，化合物的浓度取决于酵母菌株。酵母 S. cerevisiae（ICV）提供的高醇含量较高，而 S. bayanus 产生的酯和（中链）脂肪酸浓度较高。克尔斯塔奇葡萄酒的总酯含量为 3.34 至 11.97 毫克/升，日扎克葡萄酒的总酯含量为 8.51 至 13.68 毫克/升。在所有葡萄酒中，添加了 S. bayanus 和 Fermaid E 的 Krstač 和 Žižak 葡萄酒的总酯含量最高。酵母营养素 Fermaid E 和 O 强调了酵母的不同特性。它们对乙酯和乙酸酯的含量有显著的统计学影响。总分最高的是 ICVE 和 BayE Krstač 葡萄酒（18.1 分，满分 20 分）和 Žižak ICVE 葡萄酒（18.2 分，满分 20 分）。
{"title":"The influence of different yeast strains and yeast nutrients on the aroma of Krstač and Žižak wines","authors":"Valerija Madžgalj, Aleksandar Petrović, V. Tešević, B. Anđelković, Ivana Sofrenić","doi":"10.20450/mjcce.2023.2777","DOIUrl":"https://doi.org/10.20450/mjcce.2023.2777","url":null,"abstract":"Krstač and Žižak are autochthonous grape varieties grown in Montenegro. Although international varieties are more popular, the autochthonous varieties are very important, especially for countries developing tourism. The fermentation aromas produced during alcoholic fermentation contribute significantly to wine quality. The effects of yeasts (Saccharomyces cerevisiae and Saccharomyces bayanus) and yeast nutrients (Fermaid E and Fermaid O) on aromatic compounds in wines were investigated. Using GC/FID-MS analysis, aroma compounds in Krstač and Žižak wines were characterized and quantified. Wines produced with the addition of yeast and yeast nutrients had mostly lower total alcohol content than wines obtained by spontaneous fermentation of Krstač and Žižak varieties. The results of this study showed that the concentration of compounds depends on the yeast strains. The yeast S. cerevisiae (ICV) provided a higher content of higher alcohols, while S. bayanus produced a higher concentration of esters and (medium chain) fatty acids. Total ester content ranged from 3.34 to 11.97 mg/l for Krstač wines and 8.51 to 13.68 mg/l for Žižak wines. Among all wines, Krstač and Žižak wines produced with S. bayanus and Fermaid E addition had the highest concentration of total esters. The yeast nutrients Fermaid E and O emphasized different characteristics of the yeasts. They had a statistically significant effect on the content of ethyl and acetate esters. The highest overall scores were obtained for ICVE and BayE Krstač wines (18.1 out of 20 points) and Žižak ICVE wine (18.2 out of 20 points).","PeriodicalId":18088,"journal":{"name":"Macedonian Journal of Chemistry and Chemical Engineering","volume":"2004 3","pages":""},"PeriodicalIF":1.0,"publicationDate":"2023-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139160206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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