可可改善秀丽隐杆线虫与年龄相关的健康并延长其寿命

Q3 Medicine Nutrition and Healthy Aging Pub Date : 2021-01-20 DOI:10.3233/nha-200100
M. Munasinghe, Abdullah Almotayri, Jency Thomas, Deniz Heydarian, Maneka Weerasinghe, M. Jois
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引用次数: 7

摘要

背景:可可是多酚最丰富的膳食来源之一,其促进健康的作用已被研究,但长期食用可可如何影响与年龄相关的健康和寿命尚不清楚。目的:本研究的目的是确定长期食用可可对秀丽隐杆线虫年龄相关健康和寿命的影响。测量体长和面积作为蠕虫营养的指标。在生命的不同阶段,即第4天、第8天和第12天,使用蠕虫的运动、耐热性、认知和线粒体功能来确定与年龄相关的健康状况。此外,还对使用寿命进行了评估。结果:可可改善了与年龄相关的神经肌肉功能下降。补充可可可以延长平均寿命和中位寿命。然而,最长使用寿命没有受到影响。可可在所有年龄段都表现出对耐热性的有益影响(在幼龄(第4天)和中龄(第8天)效果更为显著)。此外,食用可可改善了与年龄相关的学习缺陷、短期记忆丧失和线粒体功能障碍。结论:长期食用可可似乎可以改善秀丽隐杆线虫与年龄相关的健康状况并延长其寿命
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Cocoa improves age-associated health and extends lifespan in C. elegans
BACKGROUND: Cocoa, one of the richest dietary sources of polyphenols has been studied for its health promoting effects, but how long-term consumption of cocoa affects age-associated health and lifespan is not well defined. OBJECTIVE: The objective of this study was to determine the effects of long-term cocoa consumption on age-associated health and lifespan in C. elegans METHODS: The standard E. coli OP50 diet of wild type C. elegans was supplemented with cocoa powder starting from L1 stage until they die. Body length and area were measured as indicators of worm nutrition. Age associated health was determined at different stages of life as day 4, day 8 and day 12 using worm locomotion, thermotolerance, cognition and mitochondrial function. In addition, lifespan was evaluated. RESULTS: Cocoa improved age-associated decline in neuromuscular function. Both mean and median lifespan were extended by cocoa supplementation. However, maximum lifespan was not affected. Cocoa showed beneficial effects on thermotolerance at all ages (more prominent effects at young (day 4) and middle (day 8) age). Further, consumption of cocoa improved age-related learning deficits, short-term memory loss and mitochondrial dysfunction. CONCLUSIONS: Long-term cocoa consumption seemed to improve age-associated health and extends lifespan in C. elegans
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来源期刊
Nutrition and Healthy Aging
Nutrition and Healthy Aging Agricultural and Biological Sciences-Food Science
CiteScore
1.70
自引率
0.00%
发文量
17
期刊介绍: Nutrition and Healthy Aging is an international forum for research on nutrition as a means of promoting healthy aging. It is particularly concerned with the impact of nutritional interventions on the metabolic and molecular mechanisms which modulate aging and age-associated diseases, including both biological responses on the part of the organism itself and its micro biome. Results emanating from both model organisms and clinical trials will be considered. With regards to the latter, the journal will be rigorous in only accepting for publication well controlled, randomized human intervention trials that conform broadly with the current EFSA and US FDA guidelines for nutritional clinical studies. The journal will publish research articles, short communications, critical reviews and conference summaries, whilst open peer commentaries will be welcomed.
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